Human Gene SULT2A1 (ENST00000222002.4) from GENCODE V44
Description: Homo sapiens sulfotransferase family 2A member 1 (SULT2A1), mRNA. (from RefSeq NM_003167) RefSeq Summary (NM_003167): This gene encodes a member of the sulfotransferase family. Sulfotransferases aid in the metabolism of drugs and endogenous compounds by converting these substances into more hydrophilic water-soluble sulfate conjugates that can be easily excreted. This protein catalyzes the sulfation of steroids and bile acids in the liver and adrenal glands, and may have a role in the inherited adrenal androgen excess in women with polycystic ovary syndrome. [provided by RefSeq, Mar 2010]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Gencode Transcript: ENST00000222002.4 Gencode Gene: ENSG00000105398.4 Transcript (Including UTRs) Position: hg38 chr19:47,870,467-47,886,315 Size: 15,849 Total Exon Count: 6 Strand: - Coding Region Position: hg38 chr19:47,871,455-47,886,257 Size: 14,803 Coding Exon Count: 6
ID:ST2A1_HUMAN DESCRIPTION: RecName: Full=Bile salt sulfotransferase; EC=2.8.2.14; AltName: Full=Dehydroepiandrosterone sulfotransferase; Short=DHEA-ST; AltName: Full=Hydroxysteroid Sulfotransferase; Short=HST; AltName: Full=ST2; AltName: Full=ST2A3; AltName: Full=Sulfotransferase 2A1; Short=ST2A1; FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands. CATALYTIC ACTIVITY: 3'-phosphoadenylyl sulfate + glycolithocholate = adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate. CATALYTIC ACTIVITY: 3'-phosphoadenylyl sulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate. SUBUNIT: Homodimer. INTERACTION: P40763:STAT3; NbExp=2; IntAct=EBI-3921363, EBI-518675; SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Liver, adrenal and at lower level in the kidney. Is present in human fetus in higher level in the adrenal than the liver and the kidney. PTM: The N-terminus is blocked. MISCELLANEOUS: Estrogens present in maternal circulation is predominantly derived from fetal dehydroepiandosterone sulfate which is hydrolyzed and metabolized to estrogens in placenta. SIMILARITY: Belongs to the sulfotransferase 1 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q06520
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006068 ethanol catabolic process GO:0006629 lipid metabolic process GO:0008202 steroid metabolic process GO:0016042 lipid catabolic process GO:0019216 regulation of lipid metabolic process GO:0030573 bile acid catabolic process GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process GO:0051923 sulfation
US Server
