Human Gene TTYH1 (ENST00000376531.3) from GENCODE V44
Description: Homo sapiens tweety family member 1 (TTYH1), transcript variant 2, mRNA. (from RefSeq NM_001005367) RefSeq Summary (NM_001005367): This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion channels. The encoded protein functions as a calcium(2+)-independent, volume-sensitive large conductance chloride(-) channel. Three transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jan 2011]. Gencode Transcript: ENST00000376531.3 Gencode Gene: ENSG00000167614.14 Transcript (Including UTRs) Position: hg38 chr19:54,415,526-54,436,719 Size: 21,194 Total Exon Count: 13 Strand: + Coding Region Position: hg38 chr19:54,415,553-54,436,366 Size: 20,814 Coding Exon Count: 13
ID:TTYH1_HUMAN DESCRIPTION: RecName: Full=Protein tweety homolog 1; Short=hTTY1; FUNCTION: Probable chloride channel. May be involved in cell adhesion (By similarity). FUNCTION: Isoform 3 may be a Ca(2+)-independent and swelling- activated chloride channel, possibly involved in regulation of cell volume. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity). TISSUE SPECIFICITY: Expressed in brain, eye, ovary and testis, and at lower levels in muscle, placenta, liver and lung. SIMILARITY: Belongs to the tweety family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H313
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
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Sequence and Links to Tools and Databases 
Microarray Expression Data 
