Human Gene CD8B (ENST00000331469.6) from GENCODE V44
Description: Homo sapiens CD8b molecule (CD8B), transcript variant 2, mRNA. (from RefSeq NM_172213) RefSeq Summary (NM_172213): The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified. [provided by RefSeq, May 2010]. Gencode Transcript: ENST00000331469.6 Gencode Gene: ENSG00000172116.23 Transcript (Including UTRs) Position: hg38 chr2:86,815,557-86,861,915 Size: 46,359 Total Exon Count: 6 Strand: - Coding Region Position: hg38 chr2:86,815,607-86,861,865 Size: 46,259 Coding Exon Count: 6
ID:CD8B_HUMAN DESCRIPTION: RecName: Full=T-cell surface glycoprotein CD8 beta chain; AltName: CD_antigen=CD8b; Flags: Precursor; FUNCTION: Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. SUBUNIT: In general heterodimer of an alpha and a beta chain linked by two disulfide bonds. SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein (Probable). SUBCELLULAR LOCATION: Isoform 2: Cell membrane; Single-pass type I membrane protein (Probable). SUBCELLULAR LOCATION: Isoform 3: Secreted (Probable). SUBCELLULAR LOCATION: Isoform 4: Cell membrane; Single-pass type I membrane protein (Probable). SUBCELLULAR LOCATION: Isoform 5: Cell membrane; Single-pass type I membrane protein (Probable). SUBCELLULAR LOCATION: Isoform 6: Secreted (Probable). SUBCELLULAR LOCATION: Isoform 7: Secreted (Probable). SUBCELLULAR LOCATION: Isoform 8: Secreted (Probable). TISSUE SPECIFICITY: Isoform 1, isoform 3, isoform 5, isoform 6, isoform 7 and isoform 8 are expressed in both thymus and peripheral CD8+ T-cells. Expression of isoform 1 is higher in thymus CD8+ T-cells than in peripheral CD8+ T-cells. Expression of isoform 6 is higher in peripheral CD8+ T-cells than in thymus CD8+ T-cells. PTM: Phosphorylated as a consequence of T-cell activation (Potential). SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) domain. SEQUENCE CAUTION: Sequence=AAD13877.1; Type=Erroneous gene model prediction; WEB RESOURCE: Name=Wikipedia; Note=CD8 entry; URL="http://en.wikipedia.org/wiki/CD8";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P10966
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0002250 adaptive immune response GO:0002376 immune system process GO:0006955 immune response GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway GO:0042110 T cell activation GO:0050690 regulation of defense response to virus by virus GO:0050776 regulation of immune response
X13445 - Human mRNA for CD8 beta-chain glycoprotein (CD8-beta.2). BX647150 - Homo sapiens mRNA; cDNA DKFZp686B15223 (from clone DKFZp686B15223). X13446 - Human mRNA for CD8 beta-chain glycoprotein (CD8-beta.3). BC100911 - Homo sapiens CD8b molecule, mRNA (cDNA clone MGC:119114 IMAGE:40003720), complete cds. BC100912 - Homo sapiens CD8b molecule, mRNA (cDNA clone MGC:119115 IMAGE:40003723), complete cds. BC100913 - Homo sapiens CD8b molecule, mRNA (cDNA clone MGC:119116 IMAGE:40003724), complete cds. BC100914 - Homo sapiens CD8b molecule, mRNA (cDNA clone MGC:119117 IMAGE:40003725), complete cds. KJ896562 - Synthetic construct Homo sapiens clone ccsbBroadEn_05956 CD8B gene, encodes complete protein. JD073603 - Sequence 54627 from Patent EP1572962. X13452 - Human mRNA for Lyt-3 protein. M36712 - Human T lymphocyte surface glycoprotein (CD8-beta) mRNA, complete cds. Y00805 - Human mRNA for CD8 T lymphocyte surface glycoprotein beta chain (mouse and rat Ly-3, Lyt-3 homologue). LP880232 - Sequence 36 from Patent WO2017181111. LP882061 - Sequence 3 from Patent WO2017181079. X13444 - Human mRNA for CD8 beta-chain glycoprotein (CD8 beta.1). AK303595 - Homo sapiens cDNA FLJ57765 complete cds, highly similar to T-cell surface glycoprotein CD8 beta chain precursor. AK303360 - Homo sapiens cDNA FLJ61012 complete cds, highly similar to T-cell surface glycoprotein CD8 beta chain precursor. JD128906 - Sequence 109930 from Patent EP1572962. MB143791 - JP 2019515670-A/2: METHODS FOR MONITORING AND TREATING CANCER. MB423115 - JP 2019521641-A/2: METHODS FOR MONITORING AND TREATING CANCER.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04514 - Cell adhesion molecules (CAMs) hsa04612 - Antigen processing and presentation hsa04640 - Hematopoietic cell lineage hsa04660 - T cell receptor signaling pathway hsa05340 - Primary immunodeficiency
Reactome (by CSHL, EBI, and GO)
Protein P10966 (Reactome details) participates in the following event(s):
R-HSA-182186 Formation of CD8:Nef:AP-2 Complex:v-ATPase Complex R-HSA-182198 Internalization of the CD8:Nef:AP-2 Complex:v-ATPase Complex R-HSA-198955 TCR complex interacts with peptide antigen-presenting MHC Class I R-HSA-182218 Nef Mediated CD8 Down-regulation R-HSA-164938 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-164952 The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-1280218 Adaptive Immune System R-HSA-162909 Host Interactions of HIV factors R-HSA-168256 Immune System R-HSA-162906 HIV Infection R-HSA-5663205 Infectious disease R-HSA-1643685 Disease