Human Gene KCNK15 (ENST00000372861.5) from GENCODE V44
Description: Homo sapiens potassium two pore domain channel subfamily K member 15 (KCNK15), mRNA. (from RefSeq NM_022358) RefSeq Summary (NM_022358): This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000372861.5 Gencode Gene: ENSG00000124249.7 Transcript (Including UTRs) Position: hg38 chr20:44,745,865-44,752,313 Size: 6,449 Total Exon Count: 2 Strand: + Coding Region Position: hg38 chr20:44,745,911-44,750,838 Size: 4,928 Coding Exon Count: 2
ID:KCNKF_HUMAN DESCRIPTION: RecName: Full=Potassium channel subfamily K member 15; AltName: Full=Acid-sensitive potassium channel protein TASK-5; AltName: Full=TWIK-related acid-sensitive K(+) channel 5; AltName: Full=Two pore potassium channel KT3.3; Short=Two pore K(+) channel KT3.3; FUNCTION: Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel. SUBUNIT: Heterodimer (Potential). SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Detected in pancreas, heart, placenta, lung, liver, kidney, ovary, testis, skeletal muscle and adrenal gland, and at lower levels in prostate, spleen and thyroid gland. POLYMORPHISM: Three variant polypeptides are known: TASK-5A, TASK- 5B and TASK-5C. The sequence shown is that of TASK-5C. SIMILARITY: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H427
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005267 potassium channel activity GO:0022841 potassium ion leak channel activity GO:0005244 voltage-gated ion channel activity
Biological Process: GO:0006811 ion transport GO:0006813 potassium ion transport GO:0030322 stabilization of membrane potential GO:0034765 regulation of ion transmembrane transport GO:0061337 cardiac conduction GO:0071805 potassium ion transmembrane transport
US Server
