Human Gene TM4SF1 (ENST00000305366.8) from GENCODE V44
Description: Homo sapiens transmembrane 4 L six family member 1 (TM4SF1), mRNA. (from RefSeq NM_014220) RefSeq Summary (NM_014220): The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000305366.8 Gencode Gene: ENSG00000169908.12 Transcript (Including UTRs) Position: hg38 chr3:149,369,022-149,377,649 Size: 8,628 Total Exon Count: 5 Strand: - Coding Region Position: hg38 chr3:149,369,866-149,377,547 Size: 7,682 Coding Exon Count: 5
ID:T4S1_HUMAN DESCRIPTION: RecName: Full=Transmembrane 4 L6 family member 1; AltName: Full=Membrane component chromosome 3 surface marker 1; AltName: Full=Tumor-associated antigen L6; SUBUNIT: Present in high molecular weight complexes in tumor cells. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Highly expressed in lung, breast, colon and ovarian carcinomas. It is also present on some normal cells, endothelial cells in particular. SIMILARITY: Belongs to the L6 tetraspanin family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P30408
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
