Human Gene ASB18 (ENST00000409749.8) from GENCODE V44
Description: Homo sapiens ankyrin repeat and SOCS box containing 18 (ASB18), mRNA. (from RefSeq NM_212556) RefSeq Summary (NM_212556): The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. [provided by RefSeq, Feb 2017]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence because no single transcript was available for the full length of the gene. The extent of this transcript is supported by orthologous data. Gencode Transcript: ENST00000409749.8 Gencode Gene: ENSG00000182177.15 Transcript (Including UTRs) Position: hg38 chr2:236,193,459-236,264,406 Size: 70,948 Total Exon Count: 6 Strand: - Coding Region Position: hg38 chr2:236,194,872-236,264,345 Size: 69,474 Coding Exon Count: 6
ID:ASB18_HUMAN DESCRIPTION: RecName: Full=Ankyrin repeat and SOCS box protein 18; Short=ASB-18; FUNCTION: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). PATHWAY: Protein modification; protein ubiquitination. DOMAIN: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin- protein ligase complexes (By similarity). SIMILARITY: Contains 6 ANK repeats. SIMILARITY: Contains 1 SOCS box domain. SEQUENCE CAUTION: Sequence=BAC85710.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6ZVZ8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
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Sequence and Links to Tools and Databases 
