Mouse Gene Kpna3 (ENSMUST00000022496.9) from GENCODE VM33
  Description: Mus musculus karyopherin (importin) alpha 3 (Kpna3), mRNA. (from RefSeq NM_008466)
Gencode Transcript: ENSMUST00000022496.9
Gencode Gene: ENSMUSG00000021929.10
Transcript (Including UTRs)
   Position: mm39 chr14:61,602,660-61,677,323 Size: 74,664 Total Exon Count: 17 Strand: -
Coding Region
   Position: mm39 chr14:61,605,080-61,677,240 Size: 72,161 Coding Exon Count: 17 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-15 19:06:27

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:61,602,660-61,677,323)mRNA (may differ from genome)Protein (521 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedSOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: Q543M7_MOUSE
DESCRIPTION: RecName: Full=Importin subunit alpha;
FUNCTION: Functions in nuclear protein import (By similarity).
SIMILARITY: Belongs to the importin alpha family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -33.1083-0.399 Picture PostScript Text
3' UTR -597.902420-0.247 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011989 - ARM-like
IPR016024 - ARM-type_fold
IPR000225 - Armadillo
IPR002652 - Importin-a_IBB
IPR024931 - Importing_su_alpha

Pfam Domains:
PF00514 - Armadillo/beta-catenin-like repeat
PF01749 - Importin beta binding domain

ModBase Predicted Comparative 3D Structure on Q543M7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserGenome BrowserNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBankRGDEnsemblEnsembl  
Protein SequenceProtein SequenceProtein SequenceProtein Sequence  
AlignmentAlignmentAlignmentAlignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008022 protein C-terminus binding
GO:0008565 protein transporter activity
GO:0061608 nuclear import signal receptor activity

Biological Process:
GO:0006606 protein import into nucleus
GO:0015031 protein transport

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  AK049373 - Mus musculus ES cells cDNA, RIKEN full-length enriched library, clone:C330037N10 product:karyopherin (importin) alpha 3, full insert sequence.
BC026885 - Mus musculus karyopherin (importin) alpha 3, mRNA (cDNA clone MGC:30454 IMAGE:3979788), complete cds.
AK161664 - Mus musculus 8 days embryo whole body cDNA, RIKEN full-length enriched library, clone:5730463G19 product:karyopherin (importin) alpha 3, full insert sequence.
AF020772 - Mus musculus importin alpha Q2 mRNA, complete cds.
AK011559 - Mus musculus 10 days embryo whole body cDNA, RIKEN full-length enriched library, clone:2610027A11 product:karyopherin (importin) alpha 3, full insert sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: ENSMUST00000022496.1, ENSMUST00000022496.2, ENSMUST00000022496.3, ENSMUST00000022496.4, ENSMUST00000022496.5, ENSMUST00000022496.6, ENSMUST00000022496.7, ENSMUST00000022496.8, NM_008466, Q543M7, Q543M7_MOUSE, uc007ufw.1, uc007ufw.2, uc007ufw.3, uc007ufw.4
UCSC ID: ENSMUST00000022496.9
RefSeq Accession: NM_008466
Protein: Q543M7

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.