ID:CEP55_MOUSE DESCRIPTION: RecName: Full=Centrosomal protein of 55 kDa; Short=Cep55; FUNCTION: Plays a role in mitotic exit and cytokinesis. Not required for microtubule nucleation. Recruits PDCD6IP and TSG101 to midbody during cytokinesis (By similarity). SUBUNIT: Homodimer. Interacts (phosphorylated on Ser-423 and Ser- 426) with PLK1. Interacts with AKAP9; the interaction occurs in interphase and is lost upon mitotic entry. Interacts with PCNT; the interaction occurs in interphase and is lost upon mitotic entry. Interacts with PDCD6IP; the interaction is direct; CEP55 binds PDCD6IP in a 2:1 stoechiometry; PDCD6IP competes with TSG101 for the same binding site. Interacts with TSG101; TSG101 competes with PDCD6IP for the same binding site; interaction is required for cytokinesis. Interacts with FAM125A, VPS37B, VPS37C and VPS28 (By similarity). SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, centrosome, centriole (By similarity). Cytoplasm, cytoskeleton, centrosome (By similarity). Cleavage furrow (By similarity). Midbody (By similarity). Note=Present at the centrosomes at interphase. A small portion is associated preferentially with the mother centriole, whereas the majority localizes to the pericentriolar material. During mitosis, loss of affinity for the centrosome at the onset of prophase and diffusion throughout the cell. Dissociation from the centrosome is phosphorylation-dependent. May remain localized at the centrosome during mitosis in certain cell types. Appears at the cleavage furrow in late anaphase and in the midbody in cytokinesis (By similarity). PTM: There is a hierachy of phosphorylation, where both Ser-423 and Ser-426 are phosphorylated at the onset of mitosis, prior to Ser-434. Phosphorylation at Ser-423 and Ser-426 is required for dissociation from the centrosome at the G2/M boundary. Phosphorylation at the 3 sites, Ser-423, Ser-426 and Ser-434, is required for protein function at the final stages of cell division to complete cytokinesis successfully (By similarity).
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF12180 - TSG101 and ALIX binding domain of CEP55
ModBase Predicted Comparative 3D Structure on Q8BT07
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000281 mitotic cytokinesis GO:0000920 cell separation after cytokinesis GO:0007049 cell cycle GO:0014066 regulation of phosphatidylinositol 3-kinase signaling GO:0045184 establishment of protein localization GO:0051301 cell division GO:0072001 renal system development GO:1904888 cranial skeletal system development
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