Mouse Gene Ntsr1 (ENSMUST00000170448.2) from GENCODE VM33
Description: Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol- calcium second messenger system. (from UniProt O88319) Gencode Transcript: ENSMUST00000170448.2 Gencode Gene: ENSMUSG00000027568.10 Transcript (Including UTRs) Position: mm39 chr2:180,142,020-180,186,012 Size: 43,993 Total Exon Count: 5 Strand: + Coding Region Position: mm39 chr2:180,142,211-180,184,573 Size: 42,363 Coding Exon Count: 4
ID:NTR1_MOUSE DESCRIPTION: RecName: Full=Neurotensin receptor type 1; Short=NT-R-1; Short=NTR1; FUNCTION: Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol- calcium second messenger system. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR1 sub-subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O88319
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004871 signal transducer activity GO:0004930 G-protein coupled receptor activity GO:0008188 neuropeptide receptor activity GO:0016492 G-protein coupled neurotensin receptor activity GO:0042802 identical protein binding GO:0042803 protein homodimerization activity GO:0046982 protein heterodimerization activity GO:0047485 protein N-terminus binding
Biological Process: GO:0001659 temperature homeostasis GO:0003085 negative regulation of systemic arterial blood pressure GO:0003254 regulation of membrane depolarization GO:0007165 signal transduction GO:0007186 G-protein coupled receptor signaling pathway GO:0007218 neuropeptide signaling pathway GO:0007612 learning GO:0008344 adult locomotory behavior GO:0014049 positive regulation of glutamate secretion GO:0014054 positive regulation of gamma-aminobutyric acid secretion GO:0033993 response to lipid GO:0043065 positive regulation of apoptotic process GO:0043066 negative regulation of apoptotic process GO:0043576 regulation of respiratory gaseous exchange GO:0050965 detection of temperature stimulus involved in sensory perception of pain GO:0051280 negative regulation of release of sequestered calcium ion into cytosol GO:0051281 positive regulation of release of sequestered calcium ion into cytosol GO:0051930 regulation of sensory perception of pain GO:0060732 positive regulation of inositol phosphate biosynthetic process GO:0070779 D-aspartate import GO:0071545 inositol phosphate catabolic process GO:0090238 positive regulation of arachidonic acid secretion GO:0097151 positive regulation of inhibitory postsynaptic potential GO:0098712 L-glutamate import across plasma membrane GO:0098900 regulation of action potential GO:2001259 positive regulation of cation channel activity
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