Science 2002,
PMID: 11786644
Szabo, Susanne J; Sullivan, Brandon M; Stemmann, Claudia; Satoskar, Abhay R; Sleckman, Barry P; Glimcher, Laurie H
T-bet is a member of the T-box family of transcription factors that appears to regulate lineage commitment in CD4 T helper (TH) lymphocytes in part by activating the hallmark TH1 cytokine, interferon-gamma (IFN-gamma). IFN-gamma is also produced by natural killer (NK) cells and most prominently by CD8 cytotoxic T cells, and is vital for the control of microbial pathogens. Although T-bet is expressed in all these cell types, it is required for control of IFN-gamma production in CD4 and NK cells, but not in CD8 cells. This difference is also apparent in the function of these cell subsets. Thus, the regulation of a single cytokine, IFN-gamma, is controlled by distinct transcriptional mechanisms within the T cell lineage.
Diseases/Pathways annotated by Medline MESH: Leishmaniasis, Cutaneous
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Text Mining Data
Dashed line = No text mining data
Manually curated Databases
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NCI Pathway Database IL12 signaling mediated by STAT4:
T-bet (TBX21)
→
IFN-gamma (IFNG)
(transcription, activates)
Evidence: mutant phenotype, assay, other species
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NCI Pathway Database IL12 signaling mediated by STAT4:
T-bet (TBX21)
→
B7 family/CD28 complex (CD28-CD80_CD86)
(transcription, activates)
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database IL12 signaling mediated by STAT4:
T-bet (TBX21)
→
STAT4 (dimer) complex (STAT4)
(transcription, activates)
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database IL12 signaling mediated by STAT4:
B7 family/CD28 complex (CD28-CD80_CD86)
→
STAT4 (dimer) complex (STAT4)
(transcription, activates)
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database IL12 signaling mediated by STAT4:
STAT3 (dimer ) complex (STAT3)
→
IFN-gamma (IFNG)
(transcription, activates)
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL12 signaling mediated by STAT4:
STAT3 (dimer ) complex (STAT3)
→
STAT4 (dimer) complex (STAT4)
(transcription, activates)
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL12 signaling mediated by STAT4:
STAT3 (dimer ) complex (STAT3)
→
T-bet (TBX21)
(transcription, activates)
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL12 signaling mediated by STAT4:
STAT4 (dimer) complex (STAT4)
→
T-bet (TBX21)
(transcription, activates)
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL12 signaling mediated by STAT4:
T-bet (TBX21)
→
IFN-gamma (IFNG)
(transcription, activates)
Evidence: mutant phenotype, assay, reporter gene, other species
-
NCI Pathway Database IL12 signaling mediated by STAT4:
T-bet (TBX21)
→
STAT4 (dimer)/JUN complex (STAT4-JUN)
(transcription, activates)
Evidence: mutant phenotype, assay, reporter gene, other species
-
NCI Pathway Database IL12 signaling mediated by STAT4:
T-bet (TBX21)
→
IL2 (IL2)
(transcription, activates)
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database IL12 signaling mediated by STAT4:
T-bet (TBX21)
→
STAT4 (dimer) complex (STAT4)
(transcription, activates)
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database IL12 signaling mediated by STAT4:
T-bet (TBX21)
→
TGFB1 (TGFB1)
(transcription, activates)
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database IL12 signaling mediated by STAT4:
T-bet (TBX21)
→
IFN-gamma (IFNG)
(transcription, activates)
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database IL12 signaling mediated by STAT4:
IL2 (IL2)
→
STAT4 (dimer) complex (STAT4)
(transcription, activates)
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database IL12 signaling mediated by STAT4:
IL2 (IL2)
→
TGFB1 (TGFB1)
(transcription, activates)
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database IL12 signaling mediated by STAT4:
IL2 (IL2)
→
IFN-gamma (IFNG)
(transcription, activates)
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database IL12 signaling mediated by STAT4:
STAT4 (dimer) complex (STAT4)
→
TGFB1 (TGFB1)
(transcription, activates)
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database IL12 signaling mediated by STAT4:
STAT4 (dimer) complex (STAT4)
→
IFN-gamma (IFNG)
(transcription, activates)
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database IL12 signaling mediated by STAT4:
TGFB1 (TGFB1)
→
IFN-gamma (IFNG)
(transcription, inhibits)
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database IL12 signaling mediated by STAT4:
T-bet (TBX21)
(transcription, activates)
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database IL12 signaling mediated by STAT4:
T-bet (TBX21)
→
STAT4 (dimer) complex (STAT4)
(transcription, activates)
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database IL12 signaling mediated by STAT4:
T-bet (TBX21)
→
IFN-gamma (IFNG)
(transcription, activates)
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database IL12 signaling mediated by STAT4:
T-bet (TBX21)
→
TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4)
(transcription, activates)
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database IL12 signaling mediated by STAT4:
Calcineurin A alpha-beta B1 ()
→
STAT4 (dimer) complex (STAT4)
(transcription, inhibits)
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database IL12 signaling mediated by STAT4:
Calcineurin A alpha-beta B1 ()
→
IFN-gamma (IFNG)
(transcription, inhibits)
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database IL12 signaling mediated by STAT4:
Calcineurin A alpha-beta B1 ()
→
TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4)
(transcription, inhibits)
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database IL12 signaling mediated by STAT4:
STAT4 (dimer) complex (STAT4)
→
IFN-gamma (IFNG)
(transcription, activates)
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database IL12 signaling mediated by STAT4:
STAT4 (dimer) complex (STAT4)
→
TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4)
(transcription, activates)
Evidence: mutant phenotype, assay, other species
In total, 58 gene pairs are associated to this article in curated databases