Gene interactions and pathways from curated databases and text-mining
Science 2002, PMID: 11786644

Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells.

Szabo, Susanne J; Sullivan, Brandon M; Stemmann, Claudia; Satoskar, Abhay R; Sleckman, Barry P; Glimcher, Laurie H

T-bet is a member of the T-box family of transcription factors that appears to regulate lineage commitment in CD4 T helper (TH) lymphocytes in part by activating the hallmark TH1 cytokine, interferon-gamma (IFN-gamma). IFN-gamma is also produced by natural killer (NK) cells and most prominently by CD8 cytotoxic T cells, and is vital for the control of microbial pathogens. Although T-bet is expressed in all these cell types, it is required for control of IFN-gamma production in CD4 and NK cells, but not in CD8 cells. This difference is also apparent in the function of these cell subsets. Thus, the regulation of a single cytokine, IFN-gamma, is controlled by distinct transcriptional mechanisms within the T cell lineage.

Diseases/Pathways annotated by Medline MESH: Leishmaniasis, Cutaneous
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Text Mining Data

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Manually curated Databases

  • NCI Pathway Database IL12 signaling mediated by STAT4: T-bet (TBX21) → IFN-gamma (IFNG) (transcription, activates)
    Evidence: mutant phenotype, assay, other species
  • NCI Pathway Database IL12 signaling mediated by STAT4: T-bet (TBX21) → B7 family/CD28 complex (CD28-CD80_CD86) (transcription, activates)
    Evidence: mutant phenotype, assay, other species
  • NCI Pathway Database IL12 signaling mediated by STAT4: T-bet (TBX21) → STAT4 (dimer) complex (STAT4) (transcription, activates)
    Evidence: mutant phenotype, assay, other species
  • NCI Pathway Database IL12 signaling mediated by STAT4: B7 family/CD28 complex (CD28-CD80_CD86) → STAT4 (dimer) complex (STAT4) (transcription, activates)
    Evidence: mutant phenotype, assay, other species
  • NCI Pathway Database IL12 signaling mediated by STAT4: STAT3 (dimer ) complex (STAT3) → IFN-gamma (IFNG) (transcription, activates)
    Evidence: mutant phenotype, physical interaction, other species
  • NCI Pathway Database IL12 signaling mediated by STAT4: STAT3 (dimer ) complex (STAT3) → STAT4 (dimer) complex (STAT4) (transcription, activates)
    Evidence: mutant phenotype, physical interaction, other species
  • NCI Pathway Database IL12 signaling mediated by STAT4: STAT3 (dimer ) complex (STAT3) → T-bet (TBX21) (transcription, activates)
    Evidence: mutant phenotype, physical interaction, other species
  • NCI Pathway Database IL12 signaling mediated by STAT4: STAT4 (dimer) complex (STAT4) → T-bet (TBX21) (transcription, activates)
    Evidence: mutant phenotype, physical interaction, other species
  • NCI Pathway Database IL12 signaling mediated by STAT4: T-bet (TBX21) → IFN-gamma (IFNG) (transcription, activates)
    Evidence: mutant phenotype, assay, reporter gene, other species
  • NCI Pathway Database IL12 signaling mediated by STAT4: T-bet (TBX21) → STAT4 (dimer)/JUN complex (STAT4-JUN) (transcription, activates)
    Evidence: mutant phenotype, assay, reporter gene, other species
  • NCI Pathway Database IL12 signaling mediated by STAT4: T-bet (TBX21) → IL2 (IL2) (transcription, activates)
    Evidence: mutant phenotype, assay, other species
  • NCI Pathway Database IL12 signaling mediated by STAT4: T-bet (TBX21) → STAT4 (dimer) complex (STAT4) (transcription, activates)
    Evidence: mutant phenotype, assay, other species
  • NCI Pathway Database IL12 signaling mediated by STAT4: T-bet (TBX21) → TGFB1 (TGFB1) (transcription, activates)
    Evidence: mutant phenotype, assay, other species
  • NCI Pathway Database IL12 signaling mediated by STAT4: T-bet (TBX21) → IFN-gamma (IFNG) (transcription, activates)
    Evidence: mutant phenotype, assay, other species
  • NCI Pathway Database IL12 signaling mediated by STAT4: IL2 (IL2) → STAT4 (dimer) complex (STAT4) (transcription, activates)
    Evidence: mutant phenotype, assay, other species
  • NCI Pathway Database IL12 signaling mediated by STAT4: IL2 (IL2) → TGFB1 (TGFB1) (transcription, activates)
    Evidence: mutant phenotype, assay, other species
  • NCI Pathway Database IL12 signaling mediated by STAT4: IL2 (IL2) → IFN-gamma (IFNG) (transcription, activates)
    Evidence: mutant phenotype, assay, other species
  • NCI Pathway Database IL12 signaling mediated by STAT4: STAT4 (dimer) complex (STAT4) → TGFB1 (TGFB1) (transcription, activates)
    Evidence: mutant phenotype, assay, other species
  • NCI Pathway Database IL12 signaling mediated by STAT4: STAT4 (dimer) complex (STAT4) → IFN-gamma (IFNG) (transcription, activates)
    Evidence: mutant phenotype, assay, other species
  • NCI Pathway Database IL12 signaling mediated by STAT4: TGFB1 (TGFB1) → IFN-gamma (IFNG) (transcription, inhibits)
    Evidence: mutant phenotype, assay, other species
  • NCI Pathway Database IL12 signaling mediated by STAT4: T-bet (TBX21) (transcription, activates)
    Evidence: mutant phenotype, assay, other species
  • NCI Pathway Database IL12 signaling mediated by STAT4: T-bet (TBX21) → STAT4 (dimer) complex (STAT4) (transcription, activates)
    Evidence: mutant phenotype, assay, other species
  • NCI Pathway Database IL12 signaling mediated by STAT4: T-bet (TBX21) → IFN-gamma (IFNG) (transcription, activates)
    Evidence: mutant phenotype, assay, other species
  • NCI Pathway Database IL12 signaling mediated by STAT4: T-bet (TBX21) → TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4) (transcription, activates)
    Evidence: mutant phenotype, assay, other species
  • NCI Pathway Database IL12 signaling mediated by STAT4: Calcineurin A alpha-beta B1 () → STAT4 (dimer) complex (STAT4) (transcription, inhibits)
    Evidence: mutant phenotype, assay, other species
  • NCI Pathway Database IL12 signaling mediated by STAT4: Calcineurin A alpha-beta B1 () → IFN-gamma (IFNG) (transcription, inhibits)
    Evidence: mutant phenotype, assay, other species
  • NCI Pathway Database IL12 signaling mediated by STAT4: Calcineurin A alpha-beta B1 () → TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4) (transcription, inhibits)
    Evidence: mutant phenotype, assay, other species
  • NCI Pathway Database IL12 signaling mediated by STAT4: STAT4 (dimer) complex (STAT4) → IFN-gamma (IFNG) (transcription, activates)
    Evidence: mutant phenotype, assay, other species
  • NCI Pathway Database IL12 signaling mediated by STAT4: STAT4 (dimer) complex (STAT4) → TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4) (transcription, activates)
    Evidence: mutant phenotype, assay, other species
In total, 58 gene pairs are associated to this article in curated databases