Int Immunopharmacol 2012,
PMID: 23006659
Du, Xiaogang; Zhao, Bing; Li, Jinyao; Cao, Xiaohan; Diao, Mingkun; Feng, Haibo; Chen, Xiaobing; Chen, Zhiyu; Zeng, Xianyin
Astragalus polysaccharides (APS), an extract from a kind of Chinese traditional herb Astragalus membranaceus, was proved to have strong immunoregulatory properties. In this study, APS was employed as an adjuvant of Hepatitis B virus (HBV) DNA vaccine (pcDS2) and its' effects on immune system of mice were investigated. Our data demonstrated that APS as an adjuvant could increase the HBsAg-specific antibody level as well as the proliferating activity of T cells. APS also could induce CD4(+) T cells to produce IL-4, IL-2 and IFN-γ and enhance IFN-γ expression of CD8(+) T cells. Moreover, APS could induce the robust activity of the cytotoxic lymphocytes (CTL). Additionally, APS could stimulate the dendritic cells (DC) maturation which is characterized by up-regulation of MHC I/II, CD40, CD80 and CD86, and decreased the frequency of the regulatory T cells (nTreg). Collectively, these findings suggest that APS is a potent adjuvant for the hepatitis B DNA vaccine and can enhance the immune responses of HBV DNA vaccine via promoting DC maturation and inhibit the Treg frequency.
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Text Mining Data
CD4 → APS: "
APS also could
induce CD4 ( + ) T cells to produce IL-4, IL-2 and IFN-? and enhance IFN-? expression of CD8 ( + ) T cells
"
CD8 → CD4: "
APS also could induce CD4 ( + ) T cells to produce IL-4, IL-2 and IFN-? and enhance IFN-? expression of CD8 ( + ) T cells
"
CD8 → APS: "
APS also could induce CD4 ( + ) T cells to produce IL-4, IL-2 and IFN-? and enhance IFN-? expression of CD8 ( + ) T cells
"
IL-2 → CD4: "
APS also could induce CD4 ( + ) T cells to produce IL-4, IL-2 and IFN-? and enhance IFN-? expression of CD8 ( + ) T cells
"
IL-2 → APS: "
APS also could induce CD4 ( + ) T cells to produce IL-4, IL-2 and IFN-? and enhance IFN-? expression of CD8 ( + ) T cells
"
IL-4 → CD4: "
APS also could induce CD4 ( + ) T cells to produce IL-4 , IL-2 and IFN-? and enhance IFN-? expression of CD8 ( + ) T cells
"
IL-4 → APS: "
APS also could induce CD4 ( + ) T cells to produce IL-4 , IL-2 and IFN-? and enhance IFN-? expression of CD8 ( + ) T cells
"
Manually curated Databases
No curated data.