Gene interactions and pathways from curated databases and text-mining
IL6: top 25 interacting genes (chr7:22766765-22771621)
Mouse over or click genes or lines for details. Dashed lines indicate interactions without text mining support. Click any gene to make it the new center. Click any line to show details about the interaction. Only IL6-interacting genes and only the most-mentioned/most-curated interactions are shown in the graph. See the Help Page for details.
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Less-frequently mentioned interactions with IL6, not among the Top 25
Other genes interacting with IL6. Mouse-over to show number of abstracts or databases. Sorted by article count (sort alphabetically).
Like above, interactions are colored by support. Grey:only text mining, light-blue:interaction database, blue:pathway database

MAPK9 ▸ TLR4 ▸ IL17A ▸ IL3 ▸ TLR2 ▸ EPHB2 ▸ CSF2 ▸
IL13 ▸ TGFB1 ▸ CRP ▸ IL5 ▸ VEGFA ▸ IL18 ▸ IL21 ▸
TLR3 ▸ IL33 ▸ ICAM1 ▸ PTGS2 ▸ IL22 ▸ IL7 ▸ TLR9 ▸
FGB ▸ CD40 ▸ IL32 ▸ IL11 ▸ INS ▸ CCL2 ▸ IL15 ▸
IL19 ▸ IL24 ▸ JAK2 ▸ IL31 ▸ IL16 ▸ IL20 ▸ JUN ▸
IL34 ▸ IL6ST ▸ IL25 ▸ IL26 ▸ IL9 ▸ SOCS3 ▸ IL27 ▸
IL37 ▸ NOS2 ▸ TLR7 ▸ TLR5 ▸ TLR1 ▸ STAT1 ▸ TLR8 ▸
TLR10 ▸ TLR6 ▸ IL12B ▸ PTH ▸ SOAT1 ▸ SAA1 ▸ CSRP1 ▸
IL1RN ▸ AKT1 ▸ AKT3 ▸ JAK1 ▸ AKT2 ▸ FOS ▸ CD79A ▸
LEP ▸ IL12A ▸ LRPPRC ▸ PIK3CA ▸ VIP ▸ RNF19A ▸ PIK3R1 ▸
LTA ▸ CRK ▸ MMP1 ▸ PTX3 ▸ CDC73 ▸ WDR61 ▸ LEO1 ▸
PAF1 ▸ ADCYAP1 ▸ CTR9 ▸ LIF ▸ CD40LG ▸ PRKAG1 ▸ FGF2 ▸
PRKAB2 ▸ PRKAG2 ▸ PRKAA1 ▸ PRKAB1 ▸ PRKAA2 ▸ IL6R ▸ PTX4 ▸
GP5 ▸ GP9 ▸ GP6 ▸ GP2 ▸ HGF ▸ EDN1 ▸ MMP3 ▸
IGF1 ▸ MYLIP ▸ MMP9 ▸ CRH ▸ JAK3 ▸ TCF3 ▸ MMP2 ▸
GRAP2 ▸ CD4 ▸ TCF7 ▸ TCF15 ▸ TCF24 ▸ TCF23 ▸ TCF25 ▸
TCF4 ▸ TCF20 ▸ TCF21 ▸ TCF19 ▸ CISH ▸ MYD88 ▸ TCF12 ▸
IFNB1 ▸ TGFB3 ▸ MMP13 ▸ CA2 ▸ NOS3 ▸ PLG ▸ TGFB2 ▸
MCL1 ▸ A2M ▸ TIMP1 ▸ PAM ▸ AHSA1 ▸ OSM ▸ CD14 ▸
HP ▸ NOS1 ▸ CEBPB ▸ PTBP1 ▸ HNRNPF ▸ PGF ▸ HMGB1 ▸
CD46 ▸ PTBP2 ▸ HNRNPH1 ▸ STAT5A ▸ NOX4 ▸ ALB ▸ CASP3 ▸
APOB ▸ CSF1 ▸ NFKBIA ▸ AR ▸ NA ▸ MT3 ▸ PRG2 ▸
TNFSF11 ▸ PI3 ▸ TAT ▸ S100A12 ▸ PRG4 ▸ PRG3 ▸ PRKAR1A ▸
CASP2 ▸ CASP5 ▸ CASP7 ▸ PRKAR1B ▸ CASP12 ▸ CASP14 ▸ CASP16 ▸
CASP9 ▸ PRKACB ▸ CASP6 ▸ CSF3 ▸ CASP10 ▸ NGF ▸ NOX5 ▸
PRKAR2B ▸ NOX1 ▸ CASP4 ▸ NOX3 ▸ CASP1 ▸ PRKACG ▸ PRKAR2A ▸
CASP8 ▸ ITIH4 ▸ ANGPT2 ▸ FOXP3 ▸ VCAM1 ▸ FAS ▸ GPI ▸
PDGFB ▸ POLDIP2 ▸ MT4 ▸ LPA ▸ SOCS1 ▸ PRL ▸ SYT1 ▸
SAA2 ▸ CALM3 ▸ FASLG ▸ SPP1 ▸ SOD3 ▸ MMP7 ▸ SOD1 ▸
MMP14 ▸ MMP11 ▸ SELE ▸ CYP19A1 ▸ CD8A ▸ MMP10 ▸ APP ▸
IRF1 ▸ HMOX1 ▸ ANG ▸ IKBKB ▸ PLA2G1B ▸ SOD2 ▸ CEBPA ▸
BCL2 ▸ NUP43 ▸ MMP8 ▸ IFI44 ▸ LBP ▸ PTPN11 ▸ MMP12 ▸
TNFRSF11B ▸ ADIPOQ ▸ SERPINE1 ▸ FCER2 ▸ MMP20 ▸ F2RL1 ▸ MMP24 ▸
CPOX ▸ MMP17 ▸ CTSB ▸ SETBP1 ▸ MMP26 ▸ MMP19 ▸ MMP25 ▸
MMP21 ▸ MMP15 ▸ MMP28 ▸ HDAC1 ▸ LPL ▸ CALML3 ▸ CCL3 ▸
CD28 ▸ ALG1 ▸ MMP16 ▸ EGF ▸ MMP27 ▸ NAALADL1 ▸ GFAP ▸
BCL3 ▸ TYR ▸ PTHLH ▸ PPARG ▸ GH1 ▸ LTF ▸ FGF7 ▸
BCL6 ▸ FGF23 ▸ FGF1 ▸ PLA2G4A ▸ MSH6 ▸ SERPINA3 ▸ FGF4 ▸
IRAK4 ▸ APC ▸ MSH3 ▸ IL23A ▸ HDAC2 ▸ NPS ▸ AGT ▸
AGTR2 ▸ SAA4 ▸ MAP3K7 ▸ ERVK-6 ▸ CSK ▸ HES1 ▸ PRDX2 ▸
PTPRC ▸ MIF ▸ FGF10 ▸ FGF12 ▸ F2R ▸ IL2RA ▸ FGF6 ▸
FGF5 ▸ SMAD3 ▸ PPARA ▸ IL1R1 ▸ FGF8 ▸ FGF21 ▸ FGF9 ▸
TP53 ▸ MSH2 ▸ CREB3 ▸ FGF16 ▸ FGF20 ▸ FGF14 ▸ CREB5 ▸
IFNA2 ▸ SKP1 ▸ KITLG ▸ CUL1 ▸ MSH4 ▸ CHUK ▸ MSH5 ▸
FGF19 ▸ FGF17 ▸ FGF18 ▸ ABCC1 ▸ LTB ▸ PDLIM7 ▸ FGF11 ▸
FGF22 ▸ CEACAM5 ▸ CREB1 ▸ FGF13 ▸ FGF3 ▸ IGF2 ▸ MTX1 ▸
PTK6 ▸ MPO ▸ MAP2K1 ▸ HSPD1 ▸ EGFR ▸ BMP2 ▸ HES3 ▸
TXN ▸ MTOR ▸ PTK2 ▸ IFNA4 ▸ HES7 ▸ HES4 ▸ ESR1 ▸
CDKN1A ▸ IFNA13 ▸ IFNA8 ▸ HES5 ▸ IFNA7 ▸ CEBPD ▸ IFNA14 ▸
HES6 ▸ CD44 ▸ SST ▸ IFNA5 ▸ MRXS5 ▸ PTK7 ▸ IFNA10 ▸
HES2 ▸ EPO ▸ UCN ▸ CXCL12 ▸ IFNA16 ▸ RHO ▸ IFNA17 ▸
CCL5 ▸ IFNA1 ▸ SMAD2 ▸ IFNA21 ▸ CD8B ▸ IFNA6 ▸ TRAF6 ▸
ANXA1 ▸ NPY ▸ STAT4 ▸ ANPEP ▸ FCGR1A ▸ SMAD4 ▸ RENBP ▸
C4BPA ▸ AVP ▸ NAMPT ▸ CXCL1 ▸ CAV1 ▸ MAP2K4 ▸ RBBP4 ▸
KLK3 ▸ HSPB1 ▸ SMAD7 ▸ CXCL10 ▸ CAV3 ▸ CNTN2 ▸ MUC1 ▸
RBBP7 ▸ IDO1 ▸ IKBKG ▸ CAV2 ▸ P2RX7 ▸ PRKCA ▸ PAEP ▸
CNTF ▸ SP1 ▸ WNK1 ▸ HAMP ▸ BAX ▸ TFPI ▸ S100B ▸
BMP6 ▸ RAG1 ▸ IRAK1 ▸ HDC ▸ ADCY1 ▸ AGTR1 ▸ ACE ▸
PDCD11 ▸ WNT5A ▸ CSE ▸ TNFRSF1B ▸ JUND ▸ RAG2 ▸ IRF3 ▸
CORT ▸ TNFRSF1A ▸ SRC ▸ TAB1 ▸ IFI27 ▸ GCG ▸ NOD2 ▸
NOD1 ▸ CD86 ▸ ADCY10 ▸ HLA-DRA ▸ IRS1 ▸ CLEC7A ▸ GZMB ▸
SELP ▸ NPPA ▸ SMAD9 ▸ MET ▸ SYK ▸ HIF1A ▸ SIN3A ▸
CAT ▸ DUSP1 ▸ BCL10 ▸ IL17RA ▸ ADCY8 ▸ SELL ▸ GIF ▸
CHAT ▸ TGFA ▸ REL ▸ CYP3A4 ▸ ADM ▸ CCR5 ▸ MBP ▸
SAP30 ▸ CD5 ▸ STS ▸ ADCY2 ▸ DDIT3 ▸ SAP130 ▸ SMAD1 ▸
HLA-DRB1 ▸ SUDS3 ▸ ADCY5 ▸ SHC1 ▸ MUC4 ▸ BMP7 ▸ NPEPPS ▸
ADCY6 ▸ SMAD5 ▸ ADCY3 ▸ SMAD6 ▸ ADCY4 ▸ ADCY9 ▸ ADCY7 ▸
NM ▸ ACP2 ▸ ARID4B ▸ ITGB1 ▸ UTP3 ▸ S100A8 ▸ POMC ▸
BTRC ▸ CYP1A1 ▸ ADORA1 ▸ ICAM4 ▸ HSP90AB1 ▸ EIF2AK2 ▸ MUC17 ▸
SFTPC ▸ ANXA6 ▸ TPO ▸ UTP15 ▸ CCND1 ▸ UTP20 ▸ PDGFA ▸
PLD2 ▸ ICAM2 ▸ IL17D ▸ MAP2K3 ▸ ICOSLG ▸ CR2 ▸ IRAK3 ▸
MUC12 ▸ PGP ▸ HSF1 ▸ CTGF ▸ TYK2 ▸ IBD9 ▸ SEA ▸
REG1A ▸ UTP23 ▸ IBD8 ▸ HSPG2 ▸ MUC8 ▸ UTP6 ▸ IBD2 ▸
MUC16 ▸ IBD3 ▸ IBD5 ▸ ATP8A2 ▸ MUC22 ▸ MAP2K7 ▸ MUC13 ▸
IL17F ▸ HRAS ▸ IGFBP1 ▸ GRB2 ▸ TNFRSF8 ▸ VAV1 ▸ FGFR3 ▸
ATF3 ▸ MOG ▸ MUC2 ▸ BCL9 ▸ CTSL ▸ ARSA ▸ APOE ▸
SETD2 ▸ EDN3 ▸ ICAM3 ▸ CYP3A ▸ LGALS1 ▸ PTPN4 ▸ UTP18 ▸
IBD6 ▸ IRF4 ▸ MUC6 ▸ IBD7 ▸ MUC21 ▸ CTF1 ▸ CXCL17 ▸
PLD1 ▸ MUC19 ▸ NLRP3 ▸ MUC20 ▸ ZFP36 ▸ BMP1 ▸ MPG ▸
PIGA ▸ MUC7 ▸ PPP2CA ▸ MAP2K5 ▸ TF ▸ MAP2K6 ▸ AHR ▸
CCL20 ▸ IBD4 ▸ MAP2K2 ▸ NCAM1 ▸ S100A9 ▸ PTGS1 ▸ TNFSF13B ▸
INA ▸ ICAM5 ▸ RETN ▸ ABCB1 ▸ ST2 ▸ BCL5 ▸ MUC15 ▸
EDN2 ▸ OPRM1 ▸ HMGCR ▸ MAF ▸ OAS2 ▸ MPL ▸ GAL ▸
PARP15 ▸ XRCC1 ▸ BMP15 ▸ CD19 ▸ GYS2 ▸ PCK1 ▸ CA1 ▸
CPB2 ▸ PARK2 ▸ IDS ▸ BMP3 ▸ FXR2 ▸ PPP2R2B ▸ SCARB1 ▸
MS4A1 ▸ HCL3 ▸ IGFBP3 ▸ PARP4 ▸ EBP ▸ CD163 ▸ BTK ▸
FOXO3 ▸ PARP12 ▸ TRPV1 ▸ WNT4 ▸ EPX ▸ GHRH ▸ CSH2 ▸
NNMT ▸ IRF5 ▸ GNA13 ▸ HSP90AA1 ▸ FXYD1 ▸ AHSG ▸ PPP2R1A ▸
OPN1LW ▸ PLD5 ▸ CCL1 ▸ NEUROD6 ▸ IRF9 ▸ GPX5 ▸ PLD3 ▸
CD1D ▸ PTS ▸ BMP5 ▸ PARP1 ▸ GNRH1 ▸ LYN ▸ PITX2 ▸
PON1 ▸ HCL1 ▸ CIB1 ▸ NEUROD1 ▸ HDAC6 ▸ TNPO1 ▸ ROR1 ▸
GPX8 ▸ NEUROD4 ▸ THBD ▸ BGLAP ▸ ATP5O ▸ HSPB3 ▸ PARP10 ▸
CXCL6 ▸ GPX4 ▸ TIMP2 ▸ CYP1A2 ▸ HDAC3 ▸ ETS2 ▸ WNT10B ▸
PGD ▸ XBP1 ▸ C1QB ▸ PARP6 ▸ PARP16 ▸ NDP ▸ RPL17 ▸
HPD ▸ HSPA5 ▸ GPX1 ▸ PLD6 ▸ CHGA ▸ PARP8 ▸ NFATC2 ▸
ESR2 ▸ PARP11 ▸ C5AR1 ▸ BCR ▸ HCK ▸ OAS1 ▸ MAPKAPK2 ▸
PARP14 ▸ PARP9 ▸ CPB1 ▸ TRNAI1 ▸ GPX7 ▸ IRF8 ▸ TRAF2 ▸
C1orf228 ▸ DNMT1 ▸ FXR1 ▸ PARP3 ▸ TGM2 ▸ SERPINF1 ▸ PARP2 ▸
NTF3 ▸ UCN2 ▸ OAS3 ▸ BPI ▸ HCL2 ▸ PLD4 ▸ GPX3 ▸
EPS8 ▸ GTF2B ▸ CD2 ▸ CD80 ▸ FUT4 ▸ TEC ▸ NEUROD2 ▸
ADORA3 ▸ PDCD4 ▸ BMP4 ▸ GYS1 ▸ BMP10 ▸ KNG1 ▸ LCN2 ▸
TSLP ▸ CX3CR1 ▸ C1QA ▸ IL1R2 ▸ CTSS ▸ PIM1 ▸ ETS1 ▸
ACHE ▸ EPS15 ▸ ITGAM ▸ CRYGEP ▸ GPX2 ▸ CXCR4 ▸ ANGPT1 ▸
ABL1 ▸ SLPI ▸ ATP7A ▸ GPX6 ▸ CLU ▸ ACR ▸ MAP3K3 ▸
MYO16 ▸ CXCL13 ▸ CALCA ▸ LGALS3 ▸ PSMB9 ▸ CD274 ▸ RASIP1 ▸
MEPE ▸ STK40 ▸ STK33 ▸ FYN ▸ GSTM1 ▸ RAB7A ▸ ASIP ▸
VIMP ▸ CHP1 ▸ STK3 ▸ STK35 ▸ ACE2 ▸ ACSM3 ▸ SFTPA1 ▸
DYNLRB1 ▸ CPA1 ▸ SERPINA6 ▸ SAA3P ▸ LYZ ▸ CXCR3 ▸ COQ2 ▸
MYO10 ▸ SOS1 ▸ PCK2 ▸ SCG2 ▸ CALM2 ▸ CXCL16 ▸ REN ▸
STK10 ▸ TFAP2A ▸ PDCD2 ▸ P2RY6 ▸ TNFAIP6 ▸ SLC33A1 ▸ CCK ▸
COQ4 ▸ CD59 ▸ MICE ▸ MTA3 ▸ GSTM4 ▸ PDCD7 ▸ BAI3 ▸
COQ7 ▸ HSPB8 ▸ IRF7 ▸ HDAC9 ▸ IGFBP2 ▸ IGFBP7 ▸ GAS6 ▸
WNT16 ▸ XIAP ▸ ITGA5 ▸ SERPING1 ▸ HDAC8 ▸ SPN ▸ ACAN ▸
MKL1 ▸ HDAC11 ▸ ITGA4 ▸ KDR ▸ THBS1 ▸ FMR1 ▸ ACD ▸
UCN3 ▸ SMN1 ▸ RABEPK ▸ PARK7 ▸ LCAT ▸ TIRAP ▸ PTPN22 ▸
MIA ▸ ATF4 ▸ CXCL3 ▸ BLVRB ▸ SDC1 ▸ IRG1 ▸ STK16 ▸
PDAP1 ▸ C5 ▸ MTA1 ▸ CHP2 ▸ IRF2 ▸ CXCL2 ▸ SMC3 ▸
TRAF1 ▸ HDAC7 ▸ P2RX1 ▸ SMC2 ▸ STEAP4 ▸ SP3 ▸ WNT6 ▸
TRD ▸ NTF4 ▸ PPP5C ▸ QRICH1 ▸ APCS ▸ CP ▸ LDLR ▸
COQ6 ▸ KRT13 ▸ VWF ▸ STK25 ▸ WAS ▸ ADIPOR1 ▸ CXCL11 ▸
FGFR2 ▸ MUC5AC ▸ GIP ▸ CD38 ▸ RAB7B ▸ FLT3LG ▸ KLRB1 ▸
RB1 ▸ DEFB114 ▸ CEBPZ ▸ AREG ▸ ADH6 ▸ CDKN2A ▸ SLC39A14 ▸
NANOG ▸ CXCL9 ▸ PINK1 ▸ AMELX ▸ KRT10 ▸ NOTCH2 ▸ AD5 ▸
TTR ▸ OXTR ▸ IL2RB ▸ TIMP3 ▸ KRT38 ▸ PRNP ▸ IGFBP5 ▸
SMC4 ▸ HDAC10 ▸ SMC5 ▸ KRT37 ▸ TBP ▸ VCP ▸ ADH7 ▸
STK19 ▸ CXCL14 ▸ BSG ▸ TSC22D3 ▸ CEACAM1 ▸ PHB ▸ CCR2 ▸
IL2RG ▸ IGFBP4 ▸ STK24 ▸ PDCD10 ▸ ABCA4 ▸ FGL1 ▸ CCR1 ▸
OXA1L ▸ RAC1 ▸ IRAK2 ▸ MTA2 ▸ DEFB4B ▸ ADH5 ▸ SERPINB5 ▸
TAC1 ▸ COL1A1 ▸ TBCC ▸ GSTM5 ▸ BDNF ▸ SMC6 ▸ C3AR1 ▸
SCG5 ▸ RUNX2 ▸ STK38 ▸ MYC ▸ LRG1 ▸ SARS ▸ PDCD6 ▸
MCC ▸ GSTM2 ▸ JUNB ▸ CCL4 ▸ DERL1 ▸ CD34 ▸ MYO19 ▸
CREBBP ▸ HCFC1 ▸ QRICH2 ▸ ICOS ▸ MCS ▸ ADH4 ▸ STK36 ▸
COQ3 ▸ TAC3 ▸ NTN1 ▸ STK11 ▸ IL1RAP ▸ APOA4 ▸ ABCG2 ▸
CDK9 ▸ WNT11 ▸ PTK2B ▸ CDK4 ▸ CALM1 ▸ TGM7 ▸ CX3CL1 ▸
EDNRA ▸ NTS ▸ ECM1 ▸ HPX ▸ CDH1 ▸ MYO6 ▸ RLN3 ▸
ANGPT4 ▸ PLA2G2D ▸ ATF1 ▸ PIAS3 ▸ WNT1 ▸ PDCD5 ▸ CD33 ▸
TAC4 ▸ IFIT1 ▸ SERPINE2 ▸ NOTCH1 ▸ SLC25A3 ▸ FLOT2 ▸ WNT2 ▸
AZU1 ▸ GAST ▸ E2F1 ▸ AIF1 ▸ CD69 ▸ PDCD1 ▸ NR0B1 ▸
ROR2 ▸ COQ9 ▸ NLRC5 ▸ HDAC5 ▸ RLN1 ▸ SCG3 ▸ STK31 ▸
RPS6KA3 ▸ TGM4 ▸ CDKN1B ▸ ARG1 ▸ VHLL ▸ GSTM3 ▸ RLN2 ▸
GCLC ▸ EEF1A2 ▸ RORC ▸ ITGA2B ▸ CXCL5 ▸ IGF1R ▸ NPY4R ▸
CRAT ▸ TRAF3IP2 ▸ HBD ▸ BAI1 ▸ HDAC4 ▸ ARG2 ▸ COQ5 ▸
NMU ▸ NT5E ▸ PC ▸ BAI2 ▸ CNR2 ▸ RAF1 ▸ TNC ▸
STK39 ▸ RBP4 ▸ POU5F1 ▸ SERPINA1 ▸ EGR1 ▸ NR4A1 ▸ STK4 ▸
CCR6 ▸ TRAF5 ▸ EREG ▸ MSC ▸ TSN ▸ CD1C ▸ ADAM17 ▸
PLAT ▸ WNT3 ▸ ECM2 ▸ MAL ▸ TNFSF10 ▸ MIP ▸ RNASE3 ▸
HNRNPA1 ▸ PTGER4 ▸ GCSAM ▸ SH3GL2 ▸ PRKD1 ▸ KAT2B ▸ NFKB2 ▸
PTPRE ▸ F12 ▸ MEOX2 ▸ PIAS1 ▸ ZBTB16 ▸ CBL ▸ PIK3C3 ▸
FOXO1 ▸ ERBB3 ▸
Data information
Please see the Gene Interactions Track Manual.