Gene interactions and pathways from curated databases and text-mining
IL6: top 25 interacting genes (chr7:22766765-22771621)
Mouse over or click genes or lines for details. Dashed lines indicate interactions without text mining support. Click any gene to make it the new center. Click any line to show details about the interaction. Only IL6-interacting genes and only the most-mentioned/most-curated interactions are shown in the graph. See the Help Page for details.
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Less-frequently mentioned interactions with IL6, not among the Top 25
Other genes interacting with IL6. Mouse-over to show number of abstracts or databases. Sorted by article count (sort alphabetically).
Like above, interactions are colored by support. Grey:only text mining, light-blue:interaction database, blue:pathway database

MAPK9 ▸ TLR4 ▸ IL17A ▸ IL3 ▸ TLR2 ▸ EPHB2 ▸ CSF2 ▸
IL13 ▸ TGFB1 ▸ CRP ▸ IL5 ▸ VEGFA ▸ IL18 ▸ IL21 ▸
TLR3 ▸ ICAM1 ▸ IL33 ▸ PTGS2 ▸ IL22 ▸ IL7 ▸ TLR9 ▸
FGB ▸ CD40 ▸ IL32 ▸ INS ▸ CCL2 ▸ IL11 ▸ IL15 ▸
IL19 ▸ IL31 ▸ JAK2 ▸ IL24 ▸ IL34 ▸ IL26 ▸ IL20 ▸
IL6ST ▸ JUN ▸ IL16 ▸ IL9 ▸ IL25 ▸ NOS2 ▸ SOCS3 ▸
IL27 ▸ IL37 ▸ TLR7 ▸ TLR1 ▸ TLR5 ▸ STAT1 ▸ TLR8 ▸
TLR10 ▸ TLR6 ▸ PTH ▸ IL12B ▸ SOAT1 ▸ SAA1 ▸ IL1RN ▸
CSRP1 ▸ FOS ▸ JAK1 ▸ AKT3 ▸ AKT1 ▸ AKT2 ▸ LEP ▸
CD79A ▸ LRPPRC ▸ IL12A ▸ VIP ▸ PIK3CA ▸ RNF19A ▸ PIK3R1 ▸
LTA ▸ CRK ▸ LEO1 ▸ CDC73 ▸ WDR61 ▸ CTR9 ▸ PTX3 ▸
CD40LG ▸ ADCYAP1 ▸ MMP1 ▸ PAF1 ▸ LIF ▸ PRKAA1 ▸ PRKAA2 ▸
PRKAG2 ▸ PRKAG1 ▸ PRKAB2 ▸ IL6R ▸ FGF2 ▸ PRKAB1 ▸ PTX4 ▸
GP6 ▸ GP2 ▸ GP9 ▸ GP5 ▸ HGF ▸ MYLIP ▸ IGF1 ▸
MMP3 ▸ MMP9 ▸ EDN1 ▸ GRAP2 ▸ JAK3 ▸ CRH ▸ TCF3 ▸
MMP2 ▸ TCF24 ▸ CD4 ▸ TCF12 ▸ TCF21 ▸ TCF23 ▸ MYD88 ▸
TCF20 ▸ TCF4 ▸ TCF15 ▸ TCF19 ▸ TCF7 ▸ TCF25 ▸ CISH ▸
CA2 ▸ MMP13 ▸ TGFB3 ▸ IFNB1 ▸ NOS3 ▸ TGFB2 ▸ MCL1 ▸
PLG ▸ A2M ▸ AHSA1 ▸ TIMP1 ▸ PAM ▸ OSM ▸ NOS1 ▸
CD14 ▸ HP ▸ HNRNPH1 ▸ PGF ▸ PTBP2 ▸ HNRNPF ▸ CD46 ▸
HMGB1 ▸ PTBP1 ▸ CEBPB ▸ ALB ▸ CASP3 ▸ NFKBIA ▸ NOX4 ▸
AR ▸ APOB ▸ MT3 ▸ STAT5A ▸ NA ▸ CSF1 ▸ PRG4 ▸
PRG2 ▸ PI3 ▸ PRG3 ▸ TAT ▸ TNFSF11 ▸ S100A12 ▸ NOX5 ▸
NOX1 ▸ PRKAR1A ▸ PRKACG ▸ PRKAR2A ▸ PRKACB ▸ PRKAR1B ▸ CASP4 ▸
CASP16 ▸ CASP7 ▸ CASP9 ▸ CASP12 ▸ CASP8 ▸ NGF ▸ CSF3 ▸
NOX3 ▸ CASP5 ▸ CASP14 ▸ CASP2 ▸ CASP1 ▸ CASP10 ▸ PRKAR2B ▸
CASP6 ▸ ANGPT2 ▸ GPI ▸ ITIH4 ▸ FAS ▸ VCAM1 ▸ MT4 ▸
FOXP3 ▸ SOCS1 ▸ POLDIP2 ▸ PRL ▸ PDGFB ▸ LPA ▸ SOD1 ▸
CYP19A1 ▸ SPP1 ▸ MMP14 ▸ SYT1 ▸ CALM3 ▸ MMP10 ▸ SELE ▸
MMP7 ▸ CD8A ▸ MMP11 ▸ SOD3 ▸ FASLG ▸ SAA2 ▸ HMOX1 ▸
TNFRSF11B ▸ BCL2 ▸ ANG ▸ NUP43 ▸ APP ▸ LBP ▸ CEBPA ▸
PLA2G1B ▸ PTPN11 ▸ IRF1 ▸ IKBKB ▸ MMP8 ▸ MMP12 ▸ IFI44 ▸
SOD2 ▸ MMP25 ▸ MMP24 ▸ HDAC1 ▸ SETBP1 ▸ MMP19 ▸ FCER2 ▸
MMP16 ▸ MMP21 ▸ NAALADL1 ▸ CALML3 ▸ MMP28 ▸ MMP20 ▸ SERPINE1 ▸
MMP17 ▸ CD28 ▸ LPL ▸ MMP15 ▸ CPOX ▸ F2RL1 ▸ MMP26 ▸
ALG1 ▸ CCL3 ▸ EGF ▸ CTSB ▸ MMP27 ▸ ADIPOQ ▸ IRAK4 ▸
FGF23 ▸ MSH6 ▸ GH1 ▸ BCL3 ▸ SAA4 ▸ MAP3K7 ▸ APC ▸
PTHLH ▸ HDAC2 ▸ PTPRC ▸ PLA2G4A ▸ IL23A ▸ HES1 ▸ SERPINA3 ▸
BCL6 ▸ ERVK-6 ▸ MSH3 ▸ PPARG ▸ TYR ▸ LTF ▸ AGT ▸
FGF7 ▸ NPS ▸ FGF1 ▸ GFAP ▸ AGTR2 ▸ CSK ▸ PRDX2 ▸
FGF4 ▸ MIF ▸ FGF17 ▸ CREB5 ▸ FGF21 ▸ IFNA2 ▸ FGF18 ▸
MTX1 ▸ TP53 ▸ FGF5 ▸ FGF16 ▸ IGF2 ▸ ABCC1 ▸ KITLG ▸
MSH5 ▸ MSH2 ▸ FGF22 ▸ FGF20 ▸ CEACAM5 ▸ FGF14 ▸ CHUK ▸
FGF6 ▸ FGF19 ▸ LTB ▸ SMAD3 ▸ FGF10 ▸ MSH4 ▸ CREB3 ▸
IL2RA ▸ FGF13 ▸ CREB1 ▸ FGF9 ▸ FGF11 ▸ IL1R1 ▸ FGF8 ▸
PPARA ▸ SKP1 ▸ FGF12 ▸ PDLIM7 ▸ CUL1 ▸ F2R ▸ FGF3 ▸
HES4 ▸ RHO ▸ PTK7 ▸ ANXA1 ▸ MTOR ▸ HES2 ▸ CEBPD ▸
HES3 ▸ HES5 ▸ CXCL12 ▸ IFNA17 ▸ CD44 ▸ EPO ▸ EGFR ▸
PTK6 ▸ SST ▸ MAP2K1 ▸ IFNA10 ▸ SMAD2 ▸ ESR1 ▸ IFNA16 ▸
IFNA6 ▸ MRXS5 ▸ MPO ▸ IFNA8 ▸ CDKN1A ▸ CD8B ▸ CCL5 ▸
IFNA13 ▸ BMP2 ▸ IFNA7 ▸ HES7 ▸ HES6 ▸ IFNA5 ▸ IFNA14 ▸
UCN ▸ TXN ▸ IFNA4 ▸ IFNA21 ▸ TRAF6 ▸ HSPD1 ▸ IFNA1 ▸
PTK2 ▸ MUC1 ▸ STAT4 ▸ AVP ▸ RBBP7 ▸ CXCL1 ▸ SMAD7 ▸
IKBKG ▸ P2RX7 ▸ CAV1 ▸ HAMP ▸ CXCL10 ▸ ANPEP ▸ NAMPT ▸
CAV3 ▸ KLK3 ▸ SMAD4 ▸ CNTN2 ▸ NPY ▸ C4BPA ▸ FCGR1A ▸
BAX ▸ RENBP ▸ CAV2 ▸ HSPB1 ▸ PRKCA ▸ WNK1 ▸ SP1 ▸
PAEP ▸ TFPI ▸ RBBP4 ▸ MAP2K4 ▸ CNTF ▸ IDO1 ▸ TGFA ▸
ADCY1 ▸ ADCY6 ▸ ADM ▸ ADCY8 ▸ CLEC7A ▸ HLA-DRB1 ▸ ACP2 ▸
JUND ▸ PDCD11 ▸ TAB1 ▸ SIN3A ▸ RAG2 ▸ CHAT ▸ STS ▸
IFI27 ▸ HLA-DRA ▸ ADCY9 ▸ ADCY7 ▸ SELP ▸ REL ▸ NM ▸
IL17RA ▸ SELL ▸ NOD1 ▸ CCR5 ▸ BCL10 ▸ HDC ▸ CSE ▸
IRAK1 ▸ GZMB ▸ ADCY10 ▸ CORT ▸ NPEPPS ▸ DUSP1 ▸ SUDS3 ▸
TNFRSF1B ▸ IRS1 ▸ ADCY2 ▸ IRF3 ▸ SMAD1 ▸ CAT ▸ RAG1 ▸
WNT5A ▸ GCG ▸ ADCY5 ▸ MET ▸ MBP ▸ CD5 ▸ CD86 ▸
SRC ▸ SMAD9 ▸ HIF1A ▸ ACE ▸ GIF ▸ TNFRSF1A ▸ NPPA ▸
DDIT3 ▸ NOD2 ▸ SAP130 ▸ SMAD5 ▸ MUC4 ▸ SAP30 ▸ SYK ▸
SMAD6 ▸ CYP3A4 ▸ ADCY4 ▸ AGTR1 ▸ BMP7 ▸ S100B ▸ SHC1 ▸
BMP6 ▸ ARID4B ▸ ADCY3 ▸ S100A9 ▸ CXCL17 ▸ HSF1 ▸ MUC12 ▸
RETN ▸ MAP2K6 ▸ IBD2 ▸ HMGCR ▸ PPP2CA ▸ MAP2K2 ▸ TPO ▸
IBD8 ▸ ST2 ▸ REG1A ▸ MOG ▸ ICAM5 ▸ MAP2K3 ▸ ATP8A2 ▸
MUC20 ▸ AHR ▸ ICAM4 ▸ MUC16 ▸ IBD9 ▸ IBD7 ▸ PIGA ▸
MUC21 ▸ UTP20 ▸ BCL5 ▸ PLD2 ▸ HSPG2 ▸ MPG ▸ PTPN4 ▸
EDN3 ▸ ARSA ▸ ABCB1 ▸ MUC19 ▸ CR2 ▸ S100A8 ▸ NCAM1 ▸
MUC22 ▸ PDGFA ▸ NLRP3 ▸ PGP ▸ SEA ▸ MAP2K5 ▸ MUC6 ▸
ZFP36 ▸ ITGB1 ▸ CTF1 ▸ OPRM1 ▸ CCL20 ▸ BCL9 ▸ LGALS1 ▸
FGFR3 ▸ TNFRSF8 ▸ IBD6 ▸ IBD3 ▸ INA ▸ UTP6 ▸ CYP3A ▸
UTP23 ▸ UTP15 ▸ IGFBP1 ▸ PTGS1 ▸ SFTPC ▸ ICOSLG ▸ GRB2 ▸
VAV1 ▸ APOE ▸ MUC13 ▸ SETD2 ▸ HRAS ▸ ANXA6 ▸ ICAM3 ▸
MAP2K7 ▸ TF ▸ EIF2AK2 ▸ CCND1 ▸ CTSL ▸ EDN2 ▸ MUC15 ▸
BMP1 ▸ PLD1 ▸ IBD4 ▸ ADORA1 ▸ MUC7 ▸ CYP1A1 ▸ MUC8 ▸
HSP90AB1 ▸ TYK2 ▸ IRF4 ▸ IL17F ▸ IRAK3 ▸ IBD5 ▸ MUC2 ▸
BTRC ▸ ICAM2 ▸ UTP3 ▸ CTGF ▸ POMC ▸ TNFSF13B ▸ UTP18 ▸
MUC17 ▸ IL17D ▸ ATF3 ▸ THBD ▸ CIB1 ▸ HCL3 ▸ SERPINF1 ▸
GPX5 ▸ PARP4 ▸ PLD3 ▸ GPX4 ▸ OPN1LW ▸ ADORA3 ▸ TRNAI1 ▸
AHSG ▸ FXR1 ▸ ANGPT1 ▸ NEUROD1 ▸ PARP3 ▸ HDAC3 ▸ ITGAM ▸
TEC ▸ BMP4 ▸ HPD ▸ GNA13 ▸ PPP2R1A ▸ PARP6 ▸ GPX8 ▸
CD163 ▸ IL1R2 ▸ EPS15 ▸ HCL2 ▸ PGD ▸ PON1 ▸ IRF5 ▸
CPB2 ▸ CCL1 ▸ ETS1 ▸ BMP5 ▸ HCL1 ▸ NDP ▸ PLD5 ▸
ETS2 ▸ PARP14 ▸ MAPKAPK2 ▸ PARP8 ▸ CLU ▸ CD2 ▸ GTF2B ▸
HCK ▸ PARP15 ▸ OAS3 ▸ TGM2 ▸ BCR ▸ C1QA ▸ DNMT1 ▸
FOXO3 ▸ WNT10B ▸ C1orf228 ▸ BTK ▸ IRF8 ▸ TRPV1 ▸ TSLP ▸
PARP1 ▸ UCN2 ▸ PCK1 ▸ OAS1 ▸ PARP9 ▸ CPB1 ▸ MAF ▸
NEUROD2 ▸ NFATC2 ▸ IRF9 ▸ LYN ▸ NNMT ▸ CTSS ▸ GPX2 ▸
PARP10 ▸ EPS8 ▸ HSP90AA1 ▸ OAS2 ▸ BPI ▸ NEUROD6 ▸ IGFBP3 ▸
XBP1 ▸ GPX6 ▸ GHRH ▸ ROR1 ▸ FXR2 ▸ SCARB1 ▸ BGLAP ▸
MS4A1 ▸ GPX1 ▸ GAL ▸ PARP16 ▸ GPX3 ▸ BMP3 ▸ MPL ▸
HSPB3 ▸ PARP12 ▸ C1QB ▸ RPL17 ▸ HSPA5 ▸ PDCD4 ▸ CRYGEP ▸
PLD6 ▸ PIM1 ▸ TNPO1 ▸ C5AR1 ▸ FXYD1 ▸ PTS ▸ CD80 ▸
PARK2 ▸ CSH2 ▸ EBP ▸ CD1D ▸ PARP2 ▸ IDS ▸ TRAF2 ▸
EPX ▸ NTF3 ▸ CXCR4 ▸ GPX7 ▸ HDAC6 ▸ SLPI ▸ CHGA ▸
ESR2 ▸ PLD4 ▸ CX3CR1 ▸ BMP10 ▸ PPP2R2B ▸ ABL1 ▸ GYS2 ▸
ATP5O ▸ FUT4 ▸ CYP1A2 ▸ NEUROD4 ▸ CXCL6 ▸ LCN2 ▸ WNT4 ▸
PARP11 ▸ PITX2 ▸ CA1 ▸ CD19 ▸ ACHE ▸ ATP7A ▸ BMP15 ▸
TIMP2 ▸ GYS1 ▸ KNG1 ▸ GNRH1 ▸ XRCC1 ▸ HDAC8 ▸ LDLR ▸
VWF ▸ ATF4 ▸ HDAC7 ▸ DERL1 ▸ FGFR2 ▸ E2F1 ▸ SP3 ▸
CCL4 ▸ PHB ▸ RBP4 ▸ SARS ▸ ECM2 ▸ BDNF ▸ CD33 ▸
IFIT1 ▸ ADIPOR1 ▸ COQ9 ▸ TBCC ▸ MUC5AC ▸ CDKN1B ▸ EGR1 ▸
COQ6 ▸ COL1A1 ▸ SOS1 ▸ AD5 ▸ PRNP ▸ TNC ▸ IL2RB ▸
TIMP3 ▸ SLC39A14 ▸ STK16 ▸ AIF1 ▸ MYO19 ▸ ITGA5 ▸ MKL1 ▸
SFTPA1 ▸ GSTM4 ▸ SMC4 ▸ LGALS3 ▸ MIP ▸ CALM1 ▸ TSC22D3 ▸
RABEPK ▸ LRG1 ▸ RLN1 ▸ BAI1 ▸ APOA4 ▸ CHP1 ▸ C3AR1 ▸
STK25 ▸ QRICH1 ▸ RAC1 ▸ CEBPZ ▸ CDK9 ▸ KRT13 ▸ GSTM3 ▸
TAC4 ▸ FLT3LG ▸ UCN3 ▸ NPY4R ▸ ADH6 ▸ CD274 ▸ MTA1 ▸
CD38 ▸ MYO16 ▸ TFAP2A ▸ QRICH2 ▸ ICOS ▸ PLAT ▸ HPX ▸
MYO10 ▸ C5 ▸ RLN3 ▸ ANGPT4 ▸ EREG ▸ XIAP ▸ BLVRB ▸
VCP ▸ NR0B1 ▸ GSTM1 ▸ MYO6 ▸ VHLL ▸ ADH4 ▸ CXCL16 ▸
CREBBP ▸ ACE2 ▸ PARK7 ▸ COQ5 ▸ ITGA4 ▸ ADAM17 ▸ CXCL3 ▸
MCS ▸ IRAK2 ▸ KRT37 ▸ PDCD6 ▸ OXTR ▸ GCLC ▸ SLC25A3 ▸
CDH1 ▸ CEACAM1 ▸ HDAC5 ▸ RNASE3 ▸ IL1RAP ▸ MIA ▸ SDC1 ▸
STK39 ▸ SCG2 ▸ MICE ▸ TRD ▸ HCFC1 ▸ CXCL11 ▸ MYC ▸
SMC5 ▸ NOTCH2 ▸ KRT10 ▸ KRT38 ▸ WNT16 ▸ AMELX ▸ HDAC11 ▸
SMN1 ▸ LYZ ▸ PIAS3 ▸ MSC ▸ SCG5 ▸ CCR6 ▸ RB1 ▸
STK11 ▸ IGF1R ▸ NT5E ▸ AZU1 ▸ SERPING1 ▸ MTA2 ▸ PTK2B ▸
KLRB1 ▸ VIMP ▸ TGM7 ▸ PSMB9 ▸ STK40 ▸ COQ7 ▸ PDCD7 ▸
PLA2G2D ▸ STK10 ▸ ARG2 ▸ EDNRA ▸ STK4 ▸ SMC3 ▸ CD1C ▸
CCR1 ▸ SERPINA6 ▸ PCK2 ▸ BAI2 ▸ NLRC5 ▸ MTA3 ▸ ROR2 ▸
STK36 ▸ CALM2 ▸ MAP3K3 ▸ ACD ▸ TRAF1 ▸ CCK ▸ OXA1L ▸
CD69 ▸ PDCD1 ▸ THBS1 ▸ APCS ▸ SMC2 ▸ TSN ▸ SLC33A1 ▸
PDAP1 ▸ ADH5 ▸ TAC1 ▸ STK38 ▸ CX3CL1 ▸ ASIP ▸ HDAC9 ▸
GSTM5 ▸ PPP5C ▸ IRF7 ▸ RPS6KA3 ▸ POU5F1 ▸ PDCD5 ▸ SAA3P ▸
RORC ▸ LCAT ▸ PDCD2 ▸ CPA1 ▸ PC ▸ TRAF3IP2 ▸ CXCR3 ▸
CXCL14 ▸ CHP2 ▸ HBD ▸ WNT11 ▸ MAL ▸ SERPINE2 ▸ CNR2 ▸
HDAC10 ▸ KDR ▸ COQ2 ▸ RAB7B ▸ SERPINA1 ▸ TBP ▸ WAS ▸
RAF1 ▸ FMR1 ▸ NTF4 ▸ ACSM3 ▸ ITGA2B ▸ SMC6 ▸ WNT2 ▸
CDKN2A ▸ IRG1 ▸ NMU ▸ IL2RG ▸ CALCA ▸ DYNLRB1 ▸ CDK4 ▸
NOTCH1 ▸ ADH7 ▸ STK3 ▸ TRAF5 ▸ HDAC4 ▸ JUNB ▸ GIP ▸
WNT3 ▸ NANOG ▸ SPN ▸ STK31 ▸ PINK1 ▸ GSTM2 ▸ FLOT2 ▸
CD34 ▸ ABCA4 ▸ IGFBP5 ▸ RUNX2 ▸ IGFBP2 ▸ CXCL5 ▸ REN ▸
GAST ▸ STK33 ▸ IRF2 ▸ TIRAP ▸ MEPE ▸ CCR2 ▸ MCC ▸
HSPB8 ▸ NTS ▸ TGM4 ▸ P2RX1 ▸ BSG ▸ COQ3 ▸ CXCL13 ▸
ACAN ▸ BAI3 ▸ PTPN22 ▸ FYN ▸ IGFBP7 ▸ WNT1 ▸ ECM1 ▸
SERPINB5 ▸ CD59 ▸ NR4A1 ▸ STK35 ▸ FGL1 ▸ TAC3 ▸ WNT6 ▸
CRAT ▸ ABCG2 ▸ STEAP4 ▸ STK24 ▸ ARG1 ▸ RLN2 ▸ GAS6 ▸
CP ▸ TNFSF10 ▸ PDCD10 ▸ DEFB114 ▸ COQ4 ▸ IGFBP4 ▸ TNFAIP6 ▸
CXCL2 ▸ TTR ▸ P2RY6 ▸ CXCL9 ▸ RAB7A ▸ NTN1 ▸ SCG3 ▸
AREG ▸ STK19 ▸ EEF1A2 ▸ RASIP1 ▸ ATF1 ▸ ACR ▸ DEFB4B ▸
HNRNPA1 ▸ FOXO1 ▸ PIAS1 ▸ GCSAM ▸ KAT2B ▸ SH3GL2 ▸ NFKB2 ▸
PTPRE ▸ CBL ▸ MEOX2 ▸ PIK3C3 ▸ PTGER4 ▸ F12 ▸ PRKD1 ▸
ERBB3 ▸ ZBTB16 ▸
Data information
Please see the Gene Interactions Track Manual.