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BRCA1 — CTBP1

Pathways - manually collected, often from reviews:

• NCI Pathway Database ATM pathway: MRN complex/ATM/MDC1/H2AX/RNF8/53BP1/BRCA1 complex (MRE11A-NBN-RAD50-ATM-H2AFX-MDC1-RNF8-TP53BP1-BRCA1) → BRCA1/CtBP/CtIP complex (BRCA1-CTBP1-RBBP8) (modification, collaborate)
  Cortez et al., Science 1999, Li et al., Nature 2000, Xu et al., Mol Cell Biol 2001, Stewart et al., Nature 2003, Lou et al., J Biol Chem 2003, Mailand et al., Cell 2007, Huen et al., Cell 2007, Kolas et al., Science 2007
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database ATM pathway: MRN complex/ATM/MDC1/H2AX/RNF8/53BP1 complex (MRE11A-NBN-RAD50-ATM-H2AFX-MDC1-RNF8-TP53BP1) → BRCA1/CtBP/CtIP complex (BRCA1-CTBP1-RBBP8) (modification, collaborate)
  Cortez et al., Science 1999, Li et al., Nature 2000, Xu et al., Mol Cell Biol 2001, Stewart et al., Nature 2003, Lou et al., J Biol Chem 2003, Mailand et al., Cell 2007, Huen et al., Cell 2007, Kolas et al., Science 2007
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database ATM pathway: CtBP/CtIP complex (RBBP8) → BRCA1/CtBP/CtIP complex (BRCA1-CTBP1-RBBP8) (modification, collaborate)
  Cortez et al., Science 1999, Li et al., Nature 2000, Xu et al., Mol Cell Biol 2001, Stewart et al., Nature 2003, Lou et al., J Biol Chem 2003, Mailand et al., Cell 2007, Huen et al., Cell 2007, Kolas et al., Science 2007
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database ATM pathway: MRN complex/ATM/MDC1/H2AX/RNF8/53BP1/BRCA1 complex (MRE11A-NBN-RAD50-ATM-H2AFX-MDC1-RNF8-TP53BP1-BRCA1) → BRCA1/CtBP/CtIP complex (BRCA1-CTBP1-RBBP8) (modification, collaborate)
  Li et al., Nature 2000, Xu et al., Cancer Res 2002, Stewart et al., Nature 2003, Mailand et al., Cell 2007, Huen et al., Cell 2007, Kolas et al., Science 2007
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database ATM pathway: MRN complex/ATM/MDC1/H2AX/RNF8/53BP1 complex (MRE11A-NBN-RAD50-ATM-H2AFX-MDC1-RNF8-TP53BP1) → BRCA1/CtBP/CtIP complex (BRCA1-CTBP1-RBBP8) (modification, collaborate)
  Li et al., Nature 2000, Xu et al., Cancer Res 2002, Stewart et al., Nature 2003, Mailand et al., Cell 2007, Huen et al., Cell 2007, Kolas et al., Science 2007
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database ATM pathway: CtBP/CtIP complex (RBBP8) → BRCA1/CtBP/CtIP complex (BRCA1-CTBP1-RBBP8) (modification, collaborate)
  Li et al., Nature 2000, Xu et al., Cancer Res 2002, Stewart et al., Nature 2003, Mailand et al., Cell 2007, Huen et al., Cell 2007, Kolas et al., Science 2007
  Evidence: mutant phenotype, assay, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: BRCA1 — CTBP1 (physical association, affinity chromatography technology) Li et al., J Biol Chem 1999*
• MIPS CORUM BRCA1-CtIP-CtBP complex: BRCA1-CtIP-CtBP complex complex (BRCA1-CTBP1-RBBP8) Li et al., J Biol Chem 1999*
• IRef Corum Interaction: Complex of RBBP8-CTBP1-BRCA1 (association, anti bait coimmunoprecipitation) Li et al., J Biol Chem 1999*
• IRef Dip Interaction: BRCA1 — CTBP1 (physical association, coimmunoprecipitation) Sum et al., J Biol Chem 2002
• IRef Hprd Interaction: BRCA1 — CTBP1 (in vivo) Li et al., J Biol Chem 1999*
• IRef Hprd Interaction: BRCA1 — CTBP1 (in vitro) Li et al., J Biol Chem 1999*
• IRef Ophid Interaction: BRCA1 — CTBP1 (aggregation, confirmational text mining) Li et al., J Biol Chem 1999*
• IRef Ophid Interaction: BRCA1 — CTBP1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: BRCA1 — CTBP1 (aggregation, confirmational text mining) Yu et al., J Biol Chem 1998*

Text-mined interactions from Literome

Delouis et al., BMC molecular biology 2005 : The stimulatory effect of two BRCA1 mutants, specifically in NT cells, implicates a tripartite BRCA1-CtIP-CtBP1 complex in the regulation of the K18 promoter
Deng et al., Oncogene 2010 (Carcinoma, Squamous Cell...) : Redox dependent Brca1 transcriptional regulation by an NADH-sensor CtBP1 ... Hence, we sought to determine if CtBP1 affects expression of the tumor suppressor Brca1 in head and neck tissue, as downregulation of Brca1 begins at the early stages of head and neck squamous cell carcinomas ( HNSCCs ) ... We found that CtBP1 represses Brca1 transcription by binding to the E2F4 site of the Brca1 promoter
Di et al., Nature structural & molecular biology 2010 : Loss of CtBP from the BRCA1 promoter through estrogen induction, depletion by RNA interference or increased NAD+/NADH ratio leads to HDAC1 dismissal, elevated histone acetylation and increased BRCA1 transcription
Deng et al., J Invest Dermatol 2013 (Disease Progression...) : Our findings suggest an important role of CtBP1 in the transcriptional control of p16INK4a and Brca1 , with CtBP1 overexpression potentially contributing to increased proliferation and DNA damage in melanoma
Yu et al., J Biol Chem 1998 : This finding suggests that BRCA1 regulates gene expression, at least in part, by modulating CtBP mediated transcriptional repression