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APC — RHOA

Text-mined interactions from Literome

Russo et al., Proc Natl Acad Sci U S A 2009 : To delineate the mechanism responsible for protease-selective signaling by PAR(1), we examined the effect of APC and thrombin on the activation of RhoA and Rac1, small GTPases that differentially regulate endothelial barrier permeability ... Thrombin caused robust RhoA signaling but not Rac1 activation, whereas APC stimulated a marked increase in Rac1 activation but not RhoA signaling, consistent with the opposing functions of these proteases on endothelial barrier integrity
Soh et al., Proc Natl Acad Sci U S A 2011 : Remarkably, we found that depletion of ß-arrestin expression by RNA interference resulted in the loss of APC induced Rac1 activation but not of thrombin stimulated RhoA signaling