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MAML2 — NOTCH4
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
NOTCH4
→
MAML2
(reaction)
-
Reactome Reaction:
NOTCH4
→
MAML2
(direct_complex)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Wu et al., Semin Cancer Biol 2004
(Cell Transformation, Neoplastic) :
Here, we review our current understanding of the
roles of the
MAML proteins in
Notch signaling, and their involvement in certain human cancers
Röser et al., Der Pathologe 2005
(Carcinoma, Mucoepidermoid...) :
The altered function of
MAML 2 causes a disruption of
NOTCH signalling which suggests a novel mechanism of tumorigenesis
Maillard et al., J Exp Med 2006
:
These findings indicate that the Notch requirement during the beta-selection checkpoint in vivo is absolute and independent of the pre-TCR, and it depends on transcriptional
activation by
Notch via the
CSL/RBP-J-MAML complex
Köchert et al., Oncogene 2011
(Lymphoma) :
Finally, in line with the essential
role of
MAML proteins for assembly and activity of the
NOTCH transcriptional complex ( NTC ) , we show that MAML derived small-peptide constructs block NOTCH activity and disrupt NTC formation in vitro
Zhang et al., Development 2013
(Hyperplasia...) :
Collectively, these findings indicated that
Maml mediated
Notch signaling plays a pivotal role in the initiation and maintenance of goblet cell differentiation for normal ocular surface morphogenesis and homeostasis through regulation of Klf4 and Klf5