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EDNRA — TNF

Text-mined interactions from Literome

Hirakata et al., J Med Microbiol 1999 : ETA also suppressed TNF production by alveolar macrophages ( AMs ) stimulated with LPS in vitro ... These findings suggest that ETA regulates TNF production in murine lung by suppressing LPS receptor expression, mRNA expression and protein synthesis and/or secretion of TNF
Müller-Alouf et al., Immunobiology 1992 (Shock, Septic) : In contrast to LPS, ETA induced only low amounts of IL-6 and no detectable TNF activities in peritoneal macrophage supernatants
Hirakata et al., Infect Immun 1993 (Bacteremia...) : Purified ETA did not stimulate the production of TNF in normal mice primed with a synthetic derivative of muramyl dipeptide in the absence of endotoxin
Ruetten et al., J Physiol Pharmacol 1997 : The generation of TNF alpha caused by ET-1 involves ( in sequence ) the ( i ) activation of ETA-receptors , ( ii ) activation of tyrosine kinase resulting in the phosphorylation of intracellular proteins, ( iii ) the activation of, hitherto, unknown transcription factors, finally resulting in ( iv ) transcription and translation of the TNF alpha gene