◀ Back to TNF

PPARGC1A — TNF

Text-mined interactions from Literome

Palomer et al., Cardiovasc Res 2009 : TNF-alpha reduces PGC-1alpha expression through NF-kappaB and p38 MAPK leading to increased glucose oxidation in a human cardiac cell model ... The mechanism by which TNF-alpha reduced PGC-1alpha expression in vitro appeared to be largely mediated via both p38 mitogen activated protein kinase and nuclear factor-kappaB pathways
Tang et al., J Cell Physiol 2010 (Muscular Atrophy) : TNF-alpha mediated reduction in PGC-1alpha may impair skeletal muscle function after cigarette smoke exposure ... These data suggest that in response to smoke exposure, TNF-alpha mediated down-regulation of PGC-1alpha may be a key step leading to vascular and myocyte dysfunction, effects that are more evident in oxidative than glycolytic skeletal muscles