Gene interactions and pathways from curated databases and text-mining

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TNF — UMOD

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Aikawa et al., Inflamm Res 2002 (Leukemia, Monocytic, Acute) : An anti-rheumatic agent T-614 inhibits NF-kappaB activation in LPS- and TNF-alpha stimulated THP-1 cells without interfering with IkappaBalpha degradation
Zhang et al., Cardiovasc Res 2002 (Arteriosclerosis) : BSA also significantly inhibited TNF alpha induced adhesion of monocytic THP-1 cells to HAEC in a dose dependent manner
Gee et al., J Immunol 2002 : All these treatments prevented CD44 induction in LPS stimulated, but not in TNF-alpha stimulated , THP-1 cells
Kang et al., Mol Pharmacol 2006 : Glabridin inhibited THP-1 cell adhesion to HUVECs stimulated by TNF-alpha and cell surface expression of ICAM-1 in TNF-alpha stimulated HUVECs
Liu et al., J Immunol 2007 : Stimulation of intestinal epithelial cell lines, macrophage-like THP-1 , and freshly isolated human monocytes with the cytokine TNF-alpha rapidly up-regulated FcRn gene expression ... Treatment of TNF stimulated THP-1 cells with the NF-kappaB-specific inhibitor or overexpression of a dominant negative mutant inhibitory NF-kappaB ( IkappaBalpha ; S32A/S36A ) resulted in down-regulation of FcRn expression
Miyazawa et al., J Toxicol Sci 2008 : Role of TNF-alpha and extracellular ATP in THP-1 cell activation following allergen exposure ... Therefore, in this study, we investigated the effect of TNF-alpha and extracellular ATP on THP-1 cell activation induced by chemical allergens
Qi et al., J Cell Physiol 2009 : Furthermore, IFN-gamma synergistically enhanced the production of CXCL10 in parallel with the activation of NF-kappaB in TNF-alpha stimulated THP-1 cells
Choi et al., Rheumatol Int 2010 : The level of IL-6 expression was strongly increased in both FLSs and THP-1 macrophages in response to IL-1beta and TNF-alpha , but the level by TNF-alpha was less than that by IL-1beta
Li et al., Zhongguo Zhong Yao Za Zhi 2010 : [ Extracts of danshen and chuanxinlian on human monocytic line THP-1 induced by TNF-alpha ] ... To investigate whether extracts of Danshen and Chuanxinlian ( SL ) could promote the function recovery in pre-monocytic cell line THP-1 induced by TNF-alpha ... SL extracts could promote the function recovery such as adhesion, migration, lipid uptake and secretion of THP-1 induced by TNF-alpha , which probably is one of the mechanisms of inhibit the inflammatory reaction in initiation and development of AS
Pech et al., Pathobiology 2013 : In the presence of THP , mRNA expression of IL-6 and TNF-a and IL-6 and NO serum levels were reduced and smooth muscle function was improved
Terunuma et al., J Neurol Sci 1989 (HTLV-I Infections) : The THP-1 conditioned medium, on the other hand, suppressed tumor necrosis factor (TNF) activity detected in the MT-2 culture
Zhang et al., Mol Cell Biol 1993 (Leukemia) : DNA mobility shift assay revealed specific binding of nuclear protein ( s ) from LAM-, LPS-, or TNF-alpha stimulated THP-1 cells to the NF-IL6 motifs
Su et al., J Immunol 1997 (Leukemia, Promyelocytic, Acute) : Uromodulin and Tamm-Horsfall protein induce human monocytes to secrete TNF and express tissue factor ... Effects of uromodulin (URO) and Tamm-Horsfall protein (THP), the most abundant proteins in the urine of pregnant and normal women, respectively, on the induction of TNF-alpha secretion and tissue factor ( TF ) expression of human monocytes were studied ... The release of URO and THP induced TNF-alpha in monocytes was dependent upon protein tyrosine kinase activation that results in tyrosine phosphorylation
Glaser et al., Biochem Pharmacol 1999 : The monocytic cell line THP-1 can be induced to express and release tumor necrosis factor alpha (TNFalpha) and both TNFalpha receptors ( p55 and p75 ) upon exposure to bacterial lipopolysaccharide (LPS)