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HSF1 — TP53

Text-mined interactions from Literome

Tanikawa et al., J Biol Chem 2000 : Induction of p53 by a genotoxic reagent in DT40 cells disrupts the HSF3-c-Myb interaction and down-regulates the expression of certain HSPs. Mutated forms of p53 found in certain tumors did not inhibit c-Myb induced HSF3 activation ... The regulation of HSF3 activity by c-Myb and p53 sheds light on the molecular events that govern HSP expression during cellular proliferation and apoptosis
Tanikawa et al., Blood Cells Mol Dis 2001 : p53 directly binds to HSF3 and blocks the interaction between c-Myb and HSF3
Li et al., Mol Carcinog 2011 : We also show, for the first time, that the heat shock transcription factor ( Hsf1 ), is required for establishment of the microtubule network in cells and for nuclear localization of p53
Nguyen et al., Biochem J 2013 (Cell Transformation, Neoplastic) : As expected, HSF1 significantly reduced clonogenicity, altering wild-type p53 target gene expression levels consistent with a role of HSF1 increasing wild-type p53 activity
Matsumoto et al., Int J Radiat Oncol Biol Phys 1998 (Glioblastoma) : This was due to the p53 dependent inhibition of heat induced HSF activation by CDDP