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CDK1 — TP53
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
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IRef Biogrid Interaction:
CDK1
—
TP53
(direct interaction, enzymatic study)
Luciani et al., J Mol Biol 2000*
-
IRef Biogrid Interaction:
CDK1
—
TP53
(physical association, affinity chromatography technology)
Ababneh et al., Biochem Biophys Res Commun 2001*
-
IRef Dip Interaction:
CDK1
—
TP53
(physical association, biochemical)
Wagner et al., Oncogene 1998*
-
IRef Dip Interaction:
CDK1
—
TP53
(physical association, experimental interaction detection)
Wagner et al., Oncogene 1998*
-
IRef Hprd Interaction:
TP53
—
CDK1
(in vitro)
Ababneh et al., Biochem Biophys Res Commun 2001*
-
IRef Hprd Interaction:
TP53
—
CDK1
(in vivo)
Ababneh et al., Biochem Biophys Res Commun 2001*
-
IRef Ophid Interaction:
CDK1
—
TP53
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Kourea et al., Am J Pathol 1999
(Cell Transformation, Neoplastic...) :
In this study, we investigated patterns of expression of
p53 and pRB,
cyclin dependent kinase inhibitors ( CKIs ) p21 and p27, as well as cyclins D1 and E, in a cohort of 35 well characterized MPNSTs and 16 NFs
Woodward et al., Anticancer Res 2000
(Barrett Esophagus...) :
P21 is a
cyclin dependent kinase inhibitor that is
activated by
p53
Jaiswal et al., Int J Oncol 2001
(Colonic Neoplasms) :
However, with
cyclin dependent kinase ( Cdk2 ) and TFIIH complex associated kinase CAK, the phosphorylation of
p53 was
increased at later time points ( 25 h )
Arnould et al., EMBO J 2002
:
Finally, our data suggest that phosphorylated CREB recruits p53 tumor suppressor protein, modifies its transcriptional activity and increases the expression of p21 ( Waf1/Cip1 ), a
p53 regulated
cyclin dependent kinase inhibitor
Wunderlich et al., Oncogene 2002
:
Taken together, these results suggest that Mdm2 activation of E2F1 occurs through the repression of
p53 dependent transcription of p21, a p53-target gene and
cyclin dependent kinase inhibitor
Clifford et al., Cancer Res 2003
(Fibrosarcoma) :
We have previously found that the overexpression of
p53 causes G ( 2 ) arrest and
represses the synthesis of
cyclin dependent kinase 1 and cyclin B1, two proteins required for cells to traverse from G ( 2 ) into M. G ( 2 ) arrest occurs in response to DNA damage caused by a variety of agents and treatments
Hill et al., J Cell Biochem 2004
:
We report that expression of dominant negative SWI/SNF enzymes does not affect
p53 mediated induction of the p21
cyclin dependent kinase inhibitor or the Mdm2 E3 ubiquitin ligase that regulates p53 in cells exposed to UV or gamma irradiation
Lum et al., J Cutan Pathol 2004
(Carcinoma, Basal Cell...) :
The other
p53 dependent,
cyclin dependent kinase inhibitor , p27(kip-1), has shown to be increased in TEps, which is consistent with this benign neoplasm 's better differentiated state
Naoe et al., Cancer Sci 2006
(Hematologic Neoplasms...) :
Nucleophosmin (NPM) is a nucleolar phosphoprotein that plays multiple roles in ribosome assembly and transport, cytoplasmic-nuclear trafficking,
centrosome duplication and
regulation of
p53
Bergstralh et al., Exp Cell Res 2007
(Lung Neoplasms) :
Mass spectroscopy identified the protein as nucleophosmin/B23 (NPM), a multifunctional protein with diverse roles : ribosome biosynthesis,
p53 regulation , nuclear-cytoplasmic shuttling, and
centrosome duplication
Shen et al., Cancer Res 2008
(Neoplasms...) :
p53-p21 pathway activation was
required for the depletion of Cyclin B1, Cyclin A, and
CDC2 in Nutlin-3a treated cells and for endoreduplication after Nutlin-3a removal
Kojima et al., Cancer Sci 2009
(Leukemia, Promyelocytic, Acute) :
We investigated the
effect of
CDK1 inhibition on
p53 signaling after simultaneous dual blockade using the CDK1 inhibitor RO-3306 and the MDM2 inhibitor Nutlin-3 in AML
Hseu et al., Evidence-based complementary and alternative medicine : eCAM 2011
:
This cell cycle blockade was associated with reductions in cyclin A and B1,
Cdc2 , and Cdc25C, and
increased p21/WAF1, Wee1, p53 and
phospho-p53 ( p-p53 ) in a dose- and time dependent manner
Kwon et al., Cancer Lett 2010
(Adenocarcinoma...) :
Induction of G1 arrest by widdrol was correlated with induction of Chk2,
p53 phosphorylation and CDK inhibitor p21 expression as well as
inhibition of cyclin E,
cyclin dependent kinase ( CDK2 ) and retinoblastoma protein ( pRB )
Nantajit et al., PloS one 2010
:
Herein, we reveal an anti-apoptotic role of mitochondrial
p53 regulated by the cell cycle complex cyclin
B1/Cdk1 in irradiated human colon cancer HCT116 cells with p53 ( +/+ ) status
Chew et al., J Biol Chem 2012
:
Sulforaphane induction of p21 ( Cip1 )
cyclin dependent kinase inhibitor expression
requires p53 and Sp1 transcription factors and is p53 dependent
Soares et al., Ecotoxicology 2012
:
Real time PCR was used to analyse the expression levels of nucleotide excision repair genes ( NER ) as well as the tumor suppressor p53 and downstream selected effectors, i.e., p21 (
cyclin dependent kinase inhibitor ), GADD45a ( growth arrest and DNA damage induced 45, alpha ), bax ( bcl2 associated X protein ) and
p53 key regulator MDM2 ( murine double minute 2 protein )
Katayose et al., Biochem Biophys Res Commun 1995
:
p53 shows its tumor suppresser activity by inducing cell cycle arrest and/or apoptosis of tumor cells and these activities are in part
mediated by p21
cyclin dependent kinase inhibitor ( also called as WAF1, Cip1 and SDI1 )
DiGiuseppe et al., Am J Pathol 1995
(Adenocarcinoma...) :
The
cyclin dependent kinase inhibitor, p21 ( also known as WAF1 and CIP1 ), is
induced by wild-type but not mutant
p53 , and recent work has implicated p21 as a downstream mediator of the growth suppressing and apoptosis promoting functions of wild-type p53
Dulić et al., Cell 1994
:
p53 dependent inhibition of
cyclin dependent kinase activities in human fibroblasts during radiation induced G1 arrest
Buckley et al., Am J Physiol 1997
:
Herein, we have determined that, in adult rat AEC2 in primary culture on Engelbreth-Holm-Swarm biomatrix ( Matrigel ) in the presence of keratinocyte growth factor, the expression of key cell cycle control elements, including cyclins A and D and cyclin dependent kinases
(cdk) 1 and 4, is increased and that retinoblastoma protein ( pRb ) phosphorylation is also
increased , with a corresponding decrease in the expression of
p53 and the cdk inhibitors ( cdkis ) p21WAF1/CIP1 and p27KIP-1 compared with cells cultured on plastic
Khan et al., Carcinogenesis 1997
:
In concert with the absence of a G1 arrest, it was found that though both chemical treatments led to increased levels of p53, only the
p53 induced by actinomycin D was transcriptionally active and
increased the levels of the
cyclin dependent kinase inhibitor, p21 ( waf1/cip1 )
Joshi et al., Cancer Gene Ther 1998
(Carcinoma, Non-Small-Cell Lung...) :
p21WAF1 ( p21 ) is a
cyclin dependent kinase inhibitor that is
induced by
p53 upon DNA damage or p53 overexpression, resulting in cell cycle arrest at the G1 checkpoint and inhibition of further cell proliferation
Leach et al., Cancer Res 1998
(Lymphoma, T-Cell) :
To determine the biochemical mechanism by which p53 inactivates the G2 checkpoint, the
effects of
p53 activation on Wee1 expression, Cdc2-Y15 phosphorylation, and cyclin B1-associated
Cdc2 kinase activity were examined ... Negative
regulation of the Wee1 expression and
Cdc2 phosphorylation by
p53 was also evident in thymus tissue from p53+/+ mice but not from p53-/- mice
Kelley et al., Oncogene 1998
(Disease Progression...) :
However, we detected induction of the p21Cip1
cyclin dependent kinase inhibitor gene during differentiation, which was markedly enhanced in the
presence of
p53
Mantel et al., Blood 1999
(Polyploidy) :
p53 has already been implicated in
centrosome regulation