Gene interactions and pathways from curated databases and text-mining

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CD8A — HLA-A

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Satoh et al., Vaccine 2005 (HIV Infections) : The ability of these HLA-A*2601 binding peptides to induce peptide-specific CD8 ( + ) T cells was tested by stimulating PBMCs from HIV-1 infected individuals having HLA-A*2601 with these peptides
Botten et al., J Virol 2006 (Lassa Fever) : We identified three peptides ( GPC ( 42-50 ), GLVGLVTFL ; GPC ( 60-68 ), SLYKGVYEL ; and GPC ( 441-449 ), YLISIFLHL ) that displayed high-affinity binding ( < or =98 nM ) to HLA-A*0201 , induced CD8 ( + ) T-cell responses of high functional avidity in HLA-A*0201 transgenic mice, and were naturally processed from native LASV GPC in human HLA-A*0201 positive target cells
Botten et al., J Virol 2007 (Lymphocytic Choriomeningitis) : We identified four HLA-A*0201 restricted peptides-nucleoprotein NP ( 69-77 ), glycoprotein precursor GPC ( 10-18 ), GPC ( 447-455 ), and zinc binding protein Z ( 49-58 ) -that displayed high-affinity binding ( < or =275 nM ) to HLA-A*0201 , induced CD8 ( + ) T-cell responses of high functional avidity in HLA-A*0201 transgenic mice, and were naturally processed from native LCMV antigens in HLA restricted human antigen presenting cells
Kvistborg et al., Hum Immunol 2008 (Neoplasms) : Characterization of a single peptide derived from cytochrome P450 1B1 that elicits spontaneous human leukocyte antigen (HLA)-A1 as well as HLA-B35 restricted CD8 T-cell responses in cancer patients
Schenk et al., Am J Transplant 2009 : Donor-reactive CD8 memory T-cell infiltration, proliferation and ICOS expression are regulated by donor class I MHC molecule expression
Tewalt et al., PLoS Pathog 2009 : Virus-specific CD8 ( + ) T cells ( T ( CD8+ ) ) are initially triggered by peptide-MHC Class I complexes on the surface of professional antigen presenting cells ( pAPC )
Takada et al., J Exp Med 2009 : However, distinct from this effect, class I MHC deprivation also enhanced naive CD8 T cell responsiveness to low-affinity ( but not high-affinity ) peptide-MHC ligands
Giannoni et al., Mol Ther 2013 (Melanoma) : Expression of human HLA-A*0201 in NSG-A2 recipient mice led to significantly increased numbers of human CD8 ( + ) and CD4 ( + ) T cells expressing the F5 TCR, compared with control NSG recipients
Guehler et al., Gastroenterology 1999 : These results suggest that CD8 ( + ) TCR gamma delta IELs do not require class I MHC for development but support the notion that antigens presented by class I MHC molecules are involved in the peripheral expansion and differentiation of this subset