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BIRC2 — NFKB1
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
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Gene Ontology Complexes protein complex:
protein complex complex (HSF1-TRMT112-HIST1H4A-UBQLN1-CDX2-USP28-HDAC5-CAV3-CANX-LHX1-TUBA3C-TUBA3E-PI4K2A-NR0B2-RYR2-NTRK1-MPP5-N6AMT1-STAP1-ZFP42-FADD-ATP6V0D1-PRKCDBP-AQP2-FNTB-PRPSAP2-WIPI2-CRB3-CRB2-PEX11A-LDB1-RBP4-TMEM102-GATA2-ADCY2-DZIP1-SYK-TUBB4B-PTPN11-KAT5-CEP290-SYP-ASF1B-PLEKHA2-KIF24-MYO5B-RGP1-CFTR-SPTBN5-VPS72-ACTA2-PRKCI-CNST-SNX4-GNAO1-NFKBIA-UBE2D2-EPB41-RAB5A-GLUL-BSND-GSK3B-SKI-XRCC6-PPM1E-TTR-TUBA1A-SUCLG1-TRIAP1-AKT1S1-MYD88-NPPB-GDF11-INCENP-PLCB3-BECN1-PRKAB1-SOD1-TUBB1-NPHS2-NPHS1-EPS8L1-GDI1-TUBB2A-TUBB2B-SUCLG2-PEX3-TUBAL3-ERLIN1-MAGED1-GCH1-TUBB-CPS1-MEF2C-ZNF703-SLC22A6-CPLX1-EIF4EBP1-TUBE1-FLNA-CD19-STX1A-HDAC2-TOMM40L-HDAC6-SMAD6-SMAD7-TLE6-SMAD2-PARD6B-STXBP1-ACR-TRPC1-PARD6A-TRPC4-PANX1-DCTN1-SOX9-PXMP2-BCR-SET-MALT1-BHMT-RILP-TRADD-HIST1H3A-MAPK1-PVALB-NFKB1-NUFIP1-ACVR2B-TAL1-FOXP3-SSX2IP-GNB2-SLC27A5-GOPC-PAX2-CXADR-AIF1L-APBA1-MYL12A-LMO2-ID2-CCDC113-DDOST-SPP2-GATAD2B-PLN-ERCC8-BIRC8-ASF1A-CAB39-BIRC3-BIRC2-CTNNB1-CORO1A-PRELID1-HAND2-CHAF1B-SCAP-GNAT3-CDC20-SMARCA4-IQGAP1-YWHAZ-CEBPA-PRPS2-AXIN1-XRCC5-YWHAQ-UVRAG-SLC51B-RGS4-RGS6-HTT-YWHAB-APCS-CDCA8-RIPK1-MTA2-SIN3A-ANXA1-NOS1-SNTA1-TRAF6-KPNB1-VCL-VCP-PTRF-PRKCZ-SKIL-RAB3A-KRIT1-SSBP3-PRPSAP1-PPP1CC-TAB1-MYO6-ACTL7A-TUBG2-MBD2-COL6A1-COL6A2-BCL3)
Helps et al., Biochem J 2000, Lauderdale et al., Proc Natl Acad Sci U S A 2000, Didichenko et al., FEBS Lett 2000, Koh et al., Curr Biol 2002, Fan et al., Mol Cell Biol 2002, Groisman et al., Cell 2003, Offenhäuser et al., Mol Biol Cell 2004, Tagami et al., Cell 2004, Doyon et al., Mol Cell Biol 2004, Moore et al., Genomics 2004, Sun et al., Mol Cell 2004, Zang et al., J Cell Biochem 2004, Tian et al., Cancer Res 2005, An et al., Biochemistry 2005, Mahajan et al., Proc Natl Acad Sci U S A 2005, Vader et al., EMBO Rep 2006, Yeh et al., J Biol Chem 2006, Li et al., Immunol Rev 2006, Agbas et al., Biochem J 2007, Swiatecka-Urban et al., J Biol Chem 2007, McKeegan et al., Mol Cell Biol 2007, Shono et al., J Am Soc Nephrol 2007, Popov et al., Cell cycle (Georgetown, Tex.) 2007, Sato et al., J Biol Chem 2008, Fitzgerald et al., J Biol Chem 2008, Lyssand et al., J Biol Chem 2008, Figaro et al., FEBS Lett 2008, Ueda et al., Proc Natl Acad Sci U S A 2008, Shimojo et al., J Biol Chem 2008, Costantini et al., Blood 2009, Mitsuishi et al., J Biol Chem 2010, Masuda et al., J Biol Chem 2010, Koch et al., J Cell Sci 2010, Boëda et al., J Biol Chem 2011, Sircoulomb et al., EMBO Mol Med 2011, Hoxhaj et al., J Cell Sci 2012, Uckun et al., Proc Natl Acad Sci U S A 2012, Pusapati et al., J Biol Chem 2012, Ghai et al., Proc Natl Acad Sci U S A 2013, Kelly et al., PLoS Biol 2013, Chiang et al., PloS one 2013, Dauphinee et al., J Immunol 2013, Potting et al., Cell Metab 2013, Ludwig et al., PLoS Biol 2013, Lee et al., Proc Natl Acad Sci U S A 2013, Kobayashi et al., J Cell Biol 2014, Zheng et al., Am J Physiol 1994, Kumar et al., Biochem Biophys Res Commun 1998, Watabe-Uchida et al., J Cell Biol 1998, Haft et al., Mol Cell Biol 1998
Text-mined interactions from Literome
Uzzo et al., Clin Cancer Res 2002
(Prostatic Neoplasms) :
In this study, we demonstrate by immunoblotting and immunohistochemistry that physiological levels of zinc inhibit activation of
nuclear factor (NF)-kappa B transcription factor in PC-3 and DU-145 human prostate cancer cells,
reduce expression of NF-kappa B-controlled antiapoptotic protein
c-IAP2 , and activate c-Jun NH ( 2 ) -terminal kinases
Imanishi et al., Clin Exp Pharmacol Physiol 2003
:
Inhibition of
NF-kappaB activation by SN50
suppressed c-IAP1 protein expression and enhanced apoptosis induced by either TNF-alpha or CH11
Wen et al., J Biol Chem 2003
(MAP Kinase Signaling System) :
Consistent with this, we found that TL1A significantly increased the production of
c-IAP2 , a known NF-kappaB dependent anti-apoptotic protein, and that the
NF-kappaB inhibitor or cycloheximide
prevented its synthesis
Nawata et al., Oncogene 2003
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
Expression of MEKK1km also reduced
NF-kappaB activation, and
inhibited antiapoptotic
c-IAP1 and c-IAP2 mRNA expression in response to the genotoxin
Misra et al., Circulation 2003
(Myocardial Infarction...) :
These studies suggest that the cytoprotective effects of
NF-kappaB are
mediated , at least in part, by Bcl-2 or
c-IAP1
Hübinger et al., Exp Hematol 2004
(Lymphoma, Large B-Cell, Diffuse) :
Furthermore, we showed that CD30 regulated expression of
cIAP1 and cIAP2 was
mediated by
NFkappaB
Kempf et al., Cell Microbiol 2005
:
The anti-apoptotic effect of B. henselae was accompanied by ( i ) the
activation of the transcription factor
NF-kappaB and ( ii ) the induction of cellular inhibitor of apoptosis proteins-1 and -2 (
cIAP-1 , -2 )
Fan et al., Oncogene 2005
:
HGF/SF induced the expression of several known NF-kappaB target genes (
cIAP-1 ( cellular inhibitor of apoptosis-1 ), cIAP-2, and TRAF-2 ( TNF receptor associated factor-2 ) ) in an
NF-kappaB dependent manner ; HGF/SF blocked the inhibition of expression of these genes by ADR
de Léséleuc et al., Cell Death Differ 2006
:
Nur77 overexpression leads to
NF-kappaB dependent induction of the antiapoptotic gene
cIAP1
Samuel et al., J Biol Chem 2006
:
Because TRAF2 regulates NF-kappaB activation, the
effects of
cIAP1 on TRAF2 mediated induction of
NF-kappaB transcriptional activity were studied using reporter gene assays
Groesdonk et al., Infect Immun 2006
:
This is associated with reduced expression of
NF-kappaB dependent antiapoptotic
c-IAP-2 and a loss of the mitochondrial transmembrane potential
Santoro et al., Nat Genet 2007
:
Using genetic and molecular approaches, we show that
Birc2 positively regulates the formation of the TNF receptor complex I in endothelial cells, thereby
promoting NF-kappaB activation and maintaining vessel integrity and stabilization
Kim et al., Cancer Lett 2008
:
In addition, treatment of PTX-2 down-regulated
NF-kappaB dependent gene expression, Cox-2, IAP-1,
IAP-2 and XIAP, at the transcriptional and translational level
Varfolomeev et al., J Biol Chem 2008
:
Here we investigate the
role of
c-IAP1 and c-IAP2 in TNFalpha stimulated activation of
NF-kappaB ... Therefore,
c-IAP1 and c-IAP2 are
required for TNFalpha stimulated RIP1 ubiquitination and
NF-kappaB activation
Mahoney et al., Proc Natl Acad Sci U S A 2008
:
Both
cIAP1 and cIAP2
regulate TNFalpha mediated
NF-kappaB activation ... Collectively, these data demonstrate that either
cIAP1 or 2 is
required for proper Rip1 polyubiquitination and
NF-kappaB activation upon TNFalpha treatment
Greene et al., Eur Respir J 2010
(Emphysema...) :
In 16HBE14o- cells but not HEK293 cells, ZAAT upregulated expression of
cIAP-1 , an upstream
regulator of
NF-kappaB
Fingas et al., Hepatology 2010
(Bile Duct Neoplasms...) :
Because
cIAP-1 and cIAP-2 also
promote nuclear factor kappa B (NF-kappaB) activation by the canonical pathway, the effect of JP1584 on this signaling pathway was examined