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FLT3 — NFKB1

Text-mined interactions from Literome

Takahashi et al., Leuk Res 2005 (Leukemia, Myeloid, Acute) : In this study, we addressed the role of Flt3 in the activation of nuclear factor-kappa B (NF-kappaB) , which is a target molecule of these kinase pathways
Griessinger et al., Leukemia 2007 (Leukemia, Myeloid, Acute) : Using Ba/F3 murine pre-B cells transfected with various mutants of FLT3 ( ITD, D835V, D835Y ) and the MV4-11 human AML line, we show that normal or oncogenic stimulation of FLT3 led to activation of NF-kappaB
Grosjean-Raillard et al., Apoptosis 2008 (Leukemia, Myeloid, Acute...) : Flt3 receptor inhibition reduces constitutive NFkappaB activation in high-risk myelodysplastic syndrome and acute myeloid leukemia ... Chemical inhibition or knockdown of Flt3 with small interfering RNAs reduced NFkappaB activation in MDS and AML cell lines, as well as in primary CD34 ( + ) bone marrow cells from patients, causing apoptosis