◀ Back to HSP90AA1

HSP90AA1 — HSP90AB1

Pathways - manually collected, often from reviews:

• KEGG Pathways in cancer: Complex of AR-HSP90AA1-HSP90AB1-HSP90B1 → Complex of AR (protein-protein, activation)
• KEGG Prostate cancer: Complex of AR-HSP90AA1-HSP90AB1-HSP90B1 → Complex of AR (protein-protein, activation)
• KEGG Prostate cancer: None → Complex of AR-HSP90AA1-HSP90AB1-HSP90B1 (protein-compound, activation)
  
• KEGG Prostate cancer: None → Complex of AR-HSP90AA1-HSP90AB1-HSP90B1 (protein-compound, activation)
  
• KEGG Prostate cancer: None → Complex of AR-HSP90AA1-HSP90AB1-HSP90B1 (protein-compound, activation)
  
• Reactome Reaction: HSP90AA1 → HSP90AB1 (reaction) Boyault et al., Genes Dev 2007

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: Complex of HSP90AA1-CDC37-FKBP5-HSP90AB1-IKBKB Bouwmeester et al., Nat Cell Biol 2004
• IRef Bind Interaction: Complex of IKBKG-CDC37-CCAR1-ATG16L1-HSP90AA1-HSP90AB1-IKBKB-TXLNA-TBK1 Bouwmeester et al., Nat Cell Biol 2004
• IRef Bind Interaction: Complex of 15 proteins Bouwmeester et al., Nat Cell Biol 2004
• IRef Bind Interaction: Complex of MAP3K7-CDC37-FKBP5-HSP90AA1-HSP90AB1-TAB1-TAB2 Bouwmeester et al., Nat Cell Biol 2004
• IRef Bind Interaction: Complex of FKBP5-CDC37-RPS13-HSP90AA1-HSP90AB1-RPL4-RPL30 Bouwmeester et al., Nat Cell Biol 2004
• IRef Bind Interaction: Complex of 16 proteins Bouwmeester et al., Nat Cell Biol 2004
• IRef Bind Interaction: Complex of 14 proteins Bouwmeester et al., Nat Cell Biol 2004
• IRef Bind Interaction: Complex of IKBKE-CDC37-FKBP5-HSP90AA1-HSP90AB1 Bouwmeester et al., Nat Cell Biol 2004
• IRef Biogrid Interaction: HSP90AB1 — HSP90AA1 (physical association, affinity chromatography technology) Kristensen et al., Nat Methods 2012
• IRef Biogrid Interaction: HSP90AB1 — HSP90AA1 (physical association, affinity chromatography technology) Gano et al., Mol Cell Proteomics 2010
• IRef Biogrid Interaction: HSP90AB1 — HSP90AA1 (physical association, affinity chromatography technology) Skarra et al., Proteomics 2011
• IRef Biogrid Interaction: HSP90AB1 — HSP90AA1 (physical association, affinity chromatography technology) Cheng et al., Cell Signal 2010*
• MIPS CORUM CDC37-HSP90AA1-HSP90AB1-MAP3K11 complex: CDC37-HSP90AA1-HSP90AB1-MAP3K11 complex complex (CDC37-HSP90AA1-HSP90AB1-MAP3K11) Zhang et al., J Biol Chem 2004*
• MIPS CORUM HCF-1 complex: HCF-1 complex complex (ASH2L-HCFC1-HDAC1-HDAC2-HSPA4-HSPA5-HSPA8-OGT-RBBP4-RBBP7-SAP30-SETD1A-SIN3A-SIN3B-SP1-SUDS3-WDR5-HSP90AA1-HSP90AB1) Wysocka et al., Genes Dev 2003
• MIPS CORUM HSP90-FKBP38-CAM-Ca(2+) complex: HSP90-FKBP38-CAM-Ca(2+) complex complex (CALM2-CALM3-CALM1-FKBP8-HSP90AA1-HSP90AB1) Edlich et al., J Biol Chem 2007
• MIPS CORUM Kinase maturation complex 1: Kinase maturation complex 1 complex (CDC37-HSP90AA1-HSP90AB1-HSPA4-MAP2K5-MAP3K3-MARK2-PDRG1-PFDN2-TRAF7-YWHAB-YWHAE-YWHAG-YWHAH-YWHAQ-YWHAZ) Bouwmeester et al., Nat Cell Biol 2004
• MIPS CORUM Kinase maturation complex 2: Kinase maturation complex 2 complex (AZI2-CDC37-HSP90AA1-HSP90AB1-TANK-TBK1-TBKBP1-TRAF2) Bouwmeester et al., Nat Cell Biol 2004
• MIPS CORUM IKBKB-CDC37-KIAA1967-HSP90AB1-HSP90AA1 complex: IKBKB-CDC37-KIAA1967-HSP90AB1-HSP90AA1 complex complex (CDC37-HSP90AA1-HSP90AB1-IKBKB-CCAR2) Bouwmeester et al., Nat Cell Biol 2004
• MIPS CORUM TNF-alpha/NF-kappa B signaling complex 6: TNF-alpha/NF-kappa B signaling complex 6 complex (CDC37-CHUK-FBL-HSP90AA1-HSP90AB1-IKBKB-IKBKG-MAP3K14-RPL30-RPL4-RPL6-RPL8-RPS11-RPS13) Bouwmeester et al., Nat Cell Biol 2004
• MIPS CORUM TNF-alpha/NF-kappa B signaling complex 7: TNF-alpha/NF-kappa B signaling complex 7 complex (CDC37-FKBP5-HSP90AA1-HSP90AB1-MAP3K7-TAB1-TAB2-TAB3) Bouwmeester et al., Nat Cell Biol 2004
• MIPS CORUM TNF-alpha/NF-kappa B signaling complex 8: TNF-alpha/NF-kappa B signaling complex 8 complex (CDC37-FKBP5-HSP90AA1-HSP90AB1-IKBKE-KTN1) Bouwmeester et al., Nat Cell Biol 2004
• MIPS CORUM TNF-alpha/NF-kappa B signaling complex 10: TNF-alpha/NF-kappa B signaling complex 10 complex (ATG16L1-CCAR1-CDC37-CHUK-HSP90AA1-HSP90AB1-IKBKG-NFKBIB-TBK1-TXLNA) Bouwmeester et al., Nat Cell Biol 2004
• IRef Corum Interaction: Complex of CALM1-HSP90AB1-HSP90AB1-HSP90AA1-HSP90AA1-CALM1-FKBP8-FKBP8 (association, classical fluorescence spectroscopy) Edlich et al., J Biol Chem 2007
• IRef Corum Interaction: Complex of 17 proteins (association, tandem affinity purification) Bouwmeester et al., Nat Cell Biol 2004
• IRef Corum Interaction: Complex of 15 proteins (association, tandem affinity purification) Bouwmeester et al., Nat Cell Biol 2004
• IRef Corum Interaction: Complex of 11 proteins (association, tandem affinity purification) Bouwmeester et al., Nat Cell Biol 2004
• IRef Corum Interaction: Complex of 17 proteins (association, tandem affinity purification) Bouwmeester et al., Nat Cell Biol 2004
• IRef Corum Interaction: Complex of 20 proteins (association, anti tag coimmunoprecipitation) Wysocka et al., Genes Dev 2003
• IRef Corum Interaction: Complex of 13 proteins (association, tandem affinity purification) Bouwmeester et al., Nat Cell Biol 2004
• IRef Corum Interaction: Complex of 11 proteins (association, tandem affinity purification) Bouwmeester et al., Nat Cell Biol 2004
• IRef Corum Interaction: Complex of 13 proteins (association, coimmunoprecipitation) Zhang et al., J Biol Chem 2004*
• IRef Corum Interaction: Complex of HSP90AA1-MAP3K7-TAB1-CDC37-FKBP5-HSP90AB1-TAB3-TAB2 (association, tandem affinity purification) Bouwmeester et al., Nat Cell Biol 2004
• IRef Hprd Interaction: Complex of 157 proteins (in vivo) Bouwmeester et al., Nat Cell Biol 2004
• IRef Hprd Interaction: Complex of 57 proteins (in vivo) Bouwmeester et al., Nat Cell Biol 2004
• IRef Hprd Interaction: Complex of 57 proteins (in vivo) Bouwmeester et al., Nat Cell Biol 2004
• IRef Hprd Interaction: Complex of 183 proteins (in vivo) Bouwmeester et al., Nat Cell Biol 2004
• IRef Intact Interaction: Complex of 76 proteins (association, anti tag coimmunoprecipitation) Weinmann et al., Cell 2009
• IRef Intact Interaction: Complex of 11 proteins (association, tandem affinity purification) Gano et al., Mol Cell Proteomics 2010
• IRef Intact Interaction: Complex of 33 proteins (association, tandem affinity purification) Gano et al., Mol Cell Proteomics 2010
• IRef Intact Interaction: Complex of 29 proteins (association, anti tag coimmunoprecipitation) Skarra et al., Proteomics 2011
• IRef Intact Interaction: Complex of 20 proteins (association, tandem affinity purification) Gano et al., Mol Cell Proteomics 2010
• IRef Intact Interaction: Complex of 34 proteins (association, anti bait coimmunoprecipitation) Guo et al., Proteomics 2010
• IRef Intact Interaction: Complex of 33 proteins (association, pull down) Souza-Rodrígues et al., Proteomics 2007
• IRef Intact Interaction: Complex of 43 proteins (association, anti tag coimmunoprecipitation) Weinmann et al., Cell 2009
• IRef Intact Interaction: Complex of PPP5C-HSPA1A-STIP1-HSP90AA1-PPP5C-CDC37-HSP90AB1-HSPA8-CCT4 (association, anti tag coimmunoprecipitation) Skarra et al., Proteomics 2011
• IRef Intact Interaction: Complex of 26 proteins (association, anti tag coimmunoprecipitation) Pichlmair et al., Nat Immunol 2011
• IRef Intact Interaction: Complex of YWHAG-YWHAB-CDC37-LRRK2-YWHAE-HSP90AA1-HSP90AB1-YWHAQ-YWHAZ (association, anti tag coimmunoprecipitation) Nichols et al., Biochem J 2010
• IRef Intact Interaction: Complex of 27 proteins (association, tandem affinity purification) Pichlmair et al., Nature 2012
• IRef Intact Interaction: Complex of 22 proteins (association, tandem affinity purification) Pichlmair et al., Nature 2012
• IRef Intact Interaction: Complex of 90 proteins (association, tandem affinity purification) Pichlmair et al., Nature 2012
• IRef Intact Interaction: Complex of 43 proteins (association, tandem affinity purification) Pichlmair et al., Nature 2012
• IRef Intact Interaction: Complex of LRRK2-HSP90AA1-HSP90AB1-CDC37-YWHAH-YWHAZ-YWHAQ-YWHAB-YWHAE (association, anti tag coimmunoprecipitation) Nichols et al., Biochem J 2010
• IRef Intact Interaction: Complex of 83 proteins (association, tandem affinity purification) Pichlmair et al., Nature 2012
• IRef Intact Interaction: Complex of 22 proteins (association, tandem affinity purification) Pichlmair et al., Nature 2012
• IRef Intact Interaction: Complex of 16 proteins (association, anti tag coimmunoprecipitation) Dächsel et al., Parkinsonism Relat Disord 2007
• IRef Intact Interaction: Complex of 12 proteins (association, tandem affinity purification) Varjosalo et al., Nat Methods 2013
• IRef Intact Interaction: Complex of 27 proteins (association, tandem affinity purification) Varjosalo et al., Nat Methods 2013
• IRef Intact Interaction: Complex of 22 proteins (association, tandem affinity purification) Varjosalo et al., Nat Methods 2013
• IRef Intact Interaction: Complex of 30 proteins (association, tandem affinity purification) Varjosalo et al., Nat Methods 2013
• IRef Intact Interaction: Complex of FKBP5-HSP90AA1-PRKAB1-HSP90AB1-PRKAG2-ACACA-PRKAG1-PRKAB2-PRKAA1 (association, tandem affinity purification) Varjosalo et al., Nat Methods 2013
• IRef Intact Interaction: Complex of HSP90AB1-HSP90AA1-CDKN2C-CDKN2B-CDK6-CDKN2A-TRAP1-CDK4 (association, tandem affinity purification) Varjosalo et al., Nat Methods 2013
• IRef Intact Interaction: Complex of 12 proteins (association, tandem affinity purification) Park et al., Anal Biochem 2011
• IRef Intact Interaction: Complex of 39 proteins (association, anti tag coimmunoprecipitation) Liu et al., Nature 2012
• IRef Intact Interaction: Complex of 27 proteins (association, tandem affinity purification) Varjosalo et al., Nat Methods 2013
• IRef Intact Interaction: Complex of 23 proteins (association, tandem affinity purification) Varjosalo et al., Nat Methods 2013
• IRef Intact Interaction: Complex of ADRBK1-ACACA-HSP90AB1-ADRBK2-HSP90AA1 (association, tandem affinity purification) Varjosalo et al., Nat Methods 2013
• IRef Intact Interaction: Complex of 12 proteins (association, tandem affinity purification) Li et al., Molecular systems biology 2013
• IRef Intact Interaction: Complex of 29 proteins (association, tandem affinity purification) Li et al., Molecular systems biology 2013
• IRef Intact Interaction: Complex of 306 proteins (association, pull down) Komarova et al., Mol Cell Proteomics 2011
• IRef Intact Interaction: Complex of 40 proteins (association, tandem affinity purification) Li et al., Molecular systems biology 2013
• IRef Intact Interaction: Complex of 64 proteins (association, tandem affinity purification) Li et al., Molecular systems biology 2013
• IRef Intact Interaction: Complex of 72 proteins (physical association, molecular sieving) Bernhard et al., J Am Soc Mass Spectrom 2004
• IRef Intact Interaction: Complex of 13 proteins (association, pull down) Orthwein et al., EMBO J 2012
• IRef Intact Interaction: Complex of 79 proteins (association, anti bait coimmunoprecipitation) Huang et al., Cancer Cell 2013
• IRef Intact Interaction: Complex of 156 proteins (association, anti tag coimmunoprecipitation) Lau et al., Cell 2012
• IRef Intact Interaction: Complex of 26 proteins (association, tandem affinity purification) Li et al., Molecular systems biology 2013
• IRef Intact Interaction: Complex of MYLK2-CDC37-HSP90AB1-HSP90AA1 (association, tandem affinity purification) Gano et al., Mol Cell Proteomics 2010
• IRef Intact Interaction: Complex of 29 proteins (association, tandem affinity purification) Gano et al., Mol Cell Proteomics 2010
• IRef Intact Interaction: Complex of CDC37-HSP90AB1-HSP90AA1-CALD1-MYLK2-SUGT1 (association, tandem affinity purification) Gano et al., Mol Cell Proteomics 2010
• IRef Intact Interaction: Complex of 46 proteins (association, tandem affinity purification) Gano et al., Mol Cell Proteomics 2010

Text-mined interactions from Literome

Guo et al., Drug Metab Dispos 2008 : Two-electron reduction of benzoquinone ansamycin ( BA ) heat shock protein (Hsp) 90 inhibitors by NAD(P)H:quinone oxidoreductase 1 ( NQO1 ) to hydroquinone ansamycins ( BAH2s ) leads to greater Hsp90 inhibitory activity
Ha et al., Mol Cancer Ther 2011 (Neoplasms) : Hsp90 inhibitor mediated disruption of chaperone association of ATR with hsp90 sensitizes cancer cells to DNA damage