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AGTR2 — ANGPT2

Text-mined interactions from Literome

Fujiyama et al., Circ Res 2001 : Angiotensin AT(1) and AT(2) receptors differentially regulate angiopoietin-2 and vascular endothelial growth factor expression and angiogenesis by modulating heparin binding-epidermal growth factor (EGF) mediated EGF receptor transactivation
Isenovic et al., Endocrinology 2004 (MAP Kinase Signaling System) : These results indicate that Ang II acts through both the AT(1) and AT(2) receptor to up-regulate Na ( + ) pump activity ; however, Ang II regulates alpha ( 1 ) -gene transcription through AT(1) but not AT(2) receptors
Nouet et al., J Biol Chem 2004 : The inhibitory effect of ATIP1 requires expression, but not ligand activation, of the AT2 receptor and is further increased in the presence of Ang II , indicating that ATIP1 cooperates with AT2 to transinactivate receptor tyrosine kinases
De Souza et al., Regul Pept 2004 : Pharmacological evidences demonstrate that the inhibitory effects of Ang II and Ang- ( 1-7 ) are mediated by AT2 receptor : The effect of both polypeptides is completely reversed by 10 ( -8 ) M PD 123319, a selective AT2 receptor antagonist, but is not affected by either ( 10 ( -12 ) - 10 ( -5 ) M ) losartan or ( 10 ( -10 ) -10 ( -7 ) M ) A779, selective antagonists for AT1 and AT ( 1-7 ) receptors, respectively
Zhao et al., J Neurochem 2005 : AT2 receptor activation by Ang II markedly induced mRNA and protein expression of the PPARgamma2 isoform and enhanced ligand induced PPARgamma activity in transactivation assays
Montiel-Herrera et al., Glia 2006 : The partial agonist of AT(2) receptors, CGP-42112A, exerted effects on Ang II responses, whereas the AT(1) antagonist ZD7155 did not, suggesting that Ang II responses in CC astrocytes are predominantly mediated by activation of AT(2) receptors
Liu et al., Zhonghua Zheng Xing Wai Ke Za Zhi 2007 (Cicatrix, Hypertrophic) : Both AT1 and AT2 receptors were expressed in the fibroblasts of hypertrophic scars, and Ang II regulates DNA synthesis in hypertrophic scar fibroblasts through a negative cross-talk between AT1 and AT2 receptors, which might contribute, at least partly to formation and maturation of human hypertrophic scars
Chrysant et al., Curr Clin Pharmacol 2006 (Atrial Fibrillation...) : They exert their stroke protective effect by a dual action, selectively blocking the action of Ang-II on the AT1 receptors, while allowing Ang-II to stimulate the unoccupied AT2 receptors
Casselbrant et al., Am J Physiol Gastrointest Liver Physiol 2009 : Ussing chamber technique was used to analyze the different effects of Ang II on its AT(1) and AT(2) receptors
Ptasinska-Wnuk et al., Endocrine 2012 : Both the AT1 and AT2 receptors appear to mediate the proangiogenic effects of ang II
Widdop et al., Am J Physiol 1993 : These data suggest that the hemodynamic effects of ANG II may involve concurrent, and interdependent, activation of AT1 and AT2 receptors or that PD 123319 undergoes a unique biotransformation in the brain to some product ( s ) with AT1 receptor antagonist activity
Huang et al., Adv Exp Med Biol 1996 : This effect of Ang II involved AT2 receptors, since it was inhibited by the AT2 receptor selective ligand PD123319 ( 1 microM ), but not by the Ang II type 1 receptor antagonist losartan ( 1 microM )
Cox et al., Am J Physiol 1996 : AT2 receptors do not mediate ANG II-induced vasoconstriction, thus differences in uteroplacental and systemic sensitivity to ANG II may reflect predominance of AT2 receptors in UASM and ANG II-induced increases in UA prostacyclin synthesis by endothelial AT1 receptors
Gohlke et al., Hypertension 1998 (Cerebrovascular Disorders...) : Our results demonstrate the following : ( 1 ) ANG II increases aortic cGMP by an AT2 receptor mediated action because the effect could be prevented by an AT2 receptor antagonist ; ( 2 ) the effect of ANG II was not secondary to blood pressure increase because it remained under reduction of MAP with minoxidil ; ( 3 ) losartan increased aortic cGMP most likely by increasing plasma ANG II levels with a subsequent stimulation of AT2 receptors ; and ( 4 ) the effects of AT2 receptor stimulation are mediated by BK and, subsequently, NO because they were abolished by B2 receptor blockade as well as by NO synthase inhibition
Fischer et al., Am J Physiol 1998 : In contrast to the response in endothelial cells, however, ANG II activation of MKP-1 in ARVM was mediated by AT2-receptor activation