Gene interactions and pathways from curated databases and text-mining

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EDN2 — NOS2

Text-mined interactions from Literome

Barton et al., J Am Soc Nephrol 2000 (Glomerulosclerosis, Focal Segmental...) : Dysfunctional renal nitric oxide synthase as a determinant of salt-sensitive hypertension : mechanisms of renal artery endothelial dysfunction and role of endothelin for vascular hypertrophy and Glomerulosclerosis
Ohlstein et al., J Neurosurg 1992 : An l-arginine analog inhibitor of nitric oxide synthase , L-NG-monomethyl arginine ( L-NMMA, 200 microM ), did not significantly affect basal immunoreactive endothelin levels
Novella et al., Eur J Cardiothorac Surg 2007 (Cardiovascular Diseases) : No change in the AVP response was produced by endothelium removal, exposure to the NO precursor ( 3 x 10 ( -4 ) M L-arginine ), inhibition of nitric oxide ( NO ) synthase ( 3 x 10 ( -5 ) M L-NAME ) or soluble guanylate cyclase ( 3 x 10 ( -6 ) M 1H- [ 1,2,4 ] oxadiazol [ 4,3,-alpha ] quinoxalin-1-one ( ODQ ) ), removal of the superoxide anion ( 100 U/ml superoxide dismutase ( SOD ) plus 1200 U/ml catalase ) or hydroxyl radical ( 10 ( -4 ) M deferoxamine ), or specific alpha1 - ( 10 ( -6 ) M prazosin ) or endothelin ( 10 ( -5 ) M bosentan ) receptor antagonism
Chin et al., J Periodontal Res 2009 (Mouth, Edentulous) : The roles of the endothelin receptors A and B ( ET ( A ) and ET ( B ) ) in CsA enhanced expression of PCNA and iNOS were examined in cultured human gingival fibroblasts pretreated with receptor antagonists, by immunocytochemistry and RT-PCR, respectively
Oda et al., Eur J Pharmacol 1997 : We found that in glial cell cultures lipopolysaccharide stimulated inducible NO synthase expression and nitrite accumulation were synergistically enhanced by pretreatment with endothelin, whereas endothelin itself did not induce these responses
Lin et al., Eur J Endocrinol 1998 : Role of nitric oxide synthase in release of endothelin from cultured human endometrial cells
Murayama et al., Life Sci 1998 : Regulation of inducible NO synthase expression by endothelin in primary cultured glial cells