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NOX5 — RENBP
Text-mined interactions from Literome
Wautier et al., Am J Physiol Endocrinol Metab 2001
(Diabetes Mellitus, Type 1) :
Activation of
NADPH oxidase by
AGE links oxidant stress to altered gene expression via RAGE
Gupta et al., Indian J Biochem Biophys 2007
(Diabetes Mellitus, Type 2) :
The results of the study indicate that
AGE-PMN interaction possibly
upregulates NADPH oxidase , leading to enhanced ROS generation and thus contributes to the pathogenesis in diabetes
Grossin et al., Biorheology 2009
(Diabetes Mellitus) :
AGE binding to RAGE alters endothelial cell function
stimulating NADPH oxidase and reactive oxygen species production
Toma et al., Biochem Biophys Res Commun 2009
(Hyperglycemia...) :
The addition of 25mM glucose in the culture medium enhanced the
effect of
AGE-LDL , but also of nLDL, on RAGE, p22(phox),
NOX4 , p67(phox), and MCP-1 gene expression
Kim et al., Age (Dordrecht, Netherlands) 2010
:
The most significant new finding from this study is that kaempferol supplementation prevented age related NF-kappaB activation by suppressing
AGE induced nicotinamide adenine dinucleotide phosphate oxidase (
NADPH oxidase ) ... Taken together, our results demonstrated that dietary kaempferol exerts its anti-oxidative and anti-inflammatory actions by modulating the age related NF-kappaB signaling cascade and its pro-inflammatory genes by suppressing
AGE induced
NADPH oxidase activation
Tadié et al., Am J Physiol Cell Physiol 2012
:
Incubation of neutrophils with HMGB1 diminished bacterial or
AGE dependent activation of
NADPH oxidase