Gene interactions and pathways from curated databases and text-mining

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ARSK — BCL2

Text-mined interactions from Literome

Cataldi et al., J Mol Histol 2005 (Anoxia...) : In contrast, ASK-1 mediated JNK/SAPK activation, regulating Bcl(2) levels, allows Bax homodimerization and caspase-3 activation in the same experimental conditions
Shi et al., FEBS Lett 2011 : HG induced activation of apoptosis signal regulating kinase-1 ( ASK1 ) in a time dependent manner in MMCs. Treatment with antioxidant, tempol, or knockdown of TXNIP in MMCs reduced HG-mediated apoptosis, expression of cleaved caspase-3, Bax/Bcl-2 ratio and activation of ASK1