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GHRH — IGF1

Text-mined interactions from Literome

Obál et al., Brain Res 1999 : The simultaneous inhibition of the somatotropic axis and sleep raises the possibility that the sleep alterations also result from an IGF-1 induced suppression of GHRH
Leal-Cerro et al., J Clin Endocrinol Metab 1999 (Fibromyalgia) : To gain further insight into the mechanisms leading to dysregulation of the GH-IGF-1 axis in these patients, we assessed 24-h spontaneous GH secretion, GH responses to GHRH , and IGF-1 and IGF binding protein (BP)-3 levels before and after 4 days treatment with human ( h ) GH
Sugihara et al., Neurosci Lett 1999 : We examined the effect of insulin-like growth factor-I (IGF-I) on GH-releasing factor (GRF) receptor expression in the primary rat anterior pituitary cell culture
Genazzani et al., Fertil Steril 2001 : Oral dehydroepiandrosterone supplementation modulates spontaneous and growth hormone releasing hormone induced growth hormone and insulin-like growth factor-1 secretion in early and late postmenopausal women ... However, GHRH induced GH and IGF-1 responses were not modified by DHEA supplementation
Gianotti et al., J Clin Endocrinol Metab 2002 (Hypertension...) : To clarify the impairment of the GH/IGF-I axis in obstructive sleep apnea syndrome ( OSAS ), in 13 adult male patients with OSAS ( OSA ) as well as 15 weight matched patients with simple obesity ( OB ) and 10 normal lean male subjects ( NS ), we studied : 1 ) the GH response to GHRH ( 1 micro g/kg iv ) plus arginine ( 30 g iv ) ; and 2 ) the IGF-I and IGF binding protein-3 responses to a very low dose recombinant human ( rh ) GH treatment ( 5.0 microg/kg sc per day for 4 d )
Eshet et al., J Mol Neurosci 2004 (Body Weight) : The effect of exogenous growth hormone (GH) and insulin-like growth factor I (IGF-I) on brain IGF-I binding sites ( IGF-IR ), and on the levels of growth hormone releasing hormone (GHRH) and somatostatin was studied in hypophysectomized and intact juvenile male rats
Slowinska-Srzednicka et al., J Clin Endocrinol Metab 1992 (Obesity...) : In obese women with and without PCO, a negative correlation was found between the body mass index and the peak GH responses to GHRH ( r = -0.639, P less than 0.02 ) and between age and IGF-I levels ( r = -0.520, P less than 0.05 )
Obermayr et al., Exp Gerontol 2005 (Alzheimer Disease) : The present study was designed as a randomised controlled trial to evaluate long term effects of donepezil, a cerebral selective ChEI, on basal GH and IGF-1 levels and on GH response to GHRH ( 1 microg/kg i.v., GHRH test ) before and after an 8-week donepezil treatment period
Luque et al., J Mol Endocrinol 2006 : Therefore, this study examined the effects of glucocorticoids ( dexamethasone ( 0.1-100 nM ) and hydrocortisone ( 10 nM ) ), FFA ( oleic and linoleic acid, 100 and 400 microM each ), IGF-I ( 0.5-50 nM ), and insulin ( 0.5-50 nM ) on GH release and GH, GHRH-receptor (GHRH-R) and ghrelin-receptor ( GHS-R ) mRNA levels, in primary pituitary cell cultures of baboons ( Papio anubis ) after 24 h treatment
Phatsara et al., Dev Biol (Basel) 2008 : Using the SAS system for mixed model, a highly significant association of Gh, and Igf1 to AH50 and CH50 ( p < or = 0.01 ) was detected , while Prlr and Ghrh had a highly significant association ( p < or = 0.01 ) with CH50 only
Blumbach et al., J Biol Chem 2012 (Dwarfism) : Low hepatic IGF-1 production resulted from diminished growth hormone releasing hormone expression in the hypothalamus and, subsequently, reduced growth hormone expression in the pituitary glands of these mice
Hayashi et al., No To Hattatsu 1989 (Cerebral Palsy...) : The athetotic type patients showed low somatomedin C (Sm C) concentrations ( 0.31 +/- 0.11 U/ml ), poor responses to clonidine, and good responses to GRF
Dawson-Hughes et al., J Clin Endocrinol Metab 1986 : To assess the biological effectiveness of GH in estrogen treated women, somatomedin-C (Sm-C) responses to GHRH were measured
Thorner et al., Acta Endocrinol Suppl (Copenh) 1986 (Endocrine System Diseases...) : In addition generation of IGF-1 in response to GRF appears to be dependent on an intact pituitary
Shibasaki et al., Regul Pept 1986 : These results suggest that this in vitro system is useful for the investigation of the mechanism of GHRF release from the hypothalamus and that IGF-1 is probably involved in the feedback inhibition of growth hormone secretion by attenuating GHRF release from the hypothalamus besides countering the effect of GHRF on the pituitary
Valcavi et al., Clin Endocrinol (Oxf) 1987 (Hypothyroidism) : Effect of thyroxine replacement therapy on plasma insulin-like growth factor 1 levels and growth hormone responses to growth hormone releasing factor in hypothyroid patients ... IGF-1 levels and GH responses to GRF ( 1 microgram/kg ) were measured in 21 patients with primary hypothyroidism before and after T4 replacement therapy ... T4 increased plasma IGF-1 levels ( 57.2 +/- 4.4 vs 75.9 +/- 8.8 ng/ml, mean +/- SEM, P less than 0.05 ) and GH responses to GRF as assessed both by peak GH levels ( 9 +/- 1.5 ng/ml before treatment vs 16.7 +/- 3 ng/ml after treatment, mean +/- SEM, P less than 0.05 ) and area under curve ( 496 +/- 92 before treatment vs 896 +/- 161 after treatment, mean- +/- SEM, P less than 0.05 ) ... However, no correlation was found between plasma IGF-1 levels and GH responses to GRF , suggesting that GH responses to GRF are of no predictive value in relation to the recovery of plasma IGF-1 levels following T4 replacement therapy in hypothyroid patients
Thorner et al., N Engl J Med 1985 (Dwarfism, Pituitary) : Growth hormone- releasing factor can restore growth hormone secretion and its biologic effects, including an increase in nitrogen retention, an increase in serum somatomedin C , and acceleration of linear growth in children with growth hormone deficiency
Van Vliet et al., Horm Res 1985 (Hypopituitarism) : Effect of growth hormone releasing factor on plasma growth hormone, prolactin and somatomedin C in hypopituitary and short normal children
Borges et al., Lancet 1983 (Dwarfism, Pituitary...) : Effects of human pancreatic tumour growth hormone releasing factor on growth hormone and somatomedin C levels in patients with idiopathic growth hormone deficiency
Uchiyama et al., Neuroendocrinology 1994 : In order to elucidate the effect of the growth hormone-insulin-like growth factor I ( GH-IGF-I ) axis on hypothalamic GRF and SRIF synthesis, we measured levels of mRNA coding for GRF and SRIF and for pituitary GH in pubertal male rats treated for 3 weeks with antirat GRF gamma-globulin (GRF-ab), anti-SRIF gamma-globulin ( SRIF-ab ) or both ... These data indicate that endogenous GRF is essential for normal synthesis of pituitary GH and that both GH and IGF-I negatively regulate the synthesis of hypothalamic GRF
Ghigo et al., J Endocrinol Invest 1994 : Both IGF-I levels and the GH response to iv GHRH were lower in elderly than in young subjects ( mean +/- SE, IGF-I : 65.1 +/- 9.1 vs 142.9 +/- 9.4 micrograms/L, p < 0.0001 ; GH peak : 5.4 +/- 1.0 vs 13.6 +/- 0.8 micrograms/L, p < 0.0001 )
Corpas et al., J Gerontol 1993 : Arginine/lysine did not significantly alter spontaneous or GHRH stimulated GH levels, or serum IGF-I
Wurzburger et al., J Clin Endocrinol Metab 1993 (Diabetes Mellitus, Type 1) : The 24-h GH and blood glucose profiles, insulin-like growth factor I (IGF-I) concentrations and GH responses to GRF were analyzed in 21 insulin dependent diabetics and 4 healthy subjects before and after 7 days treatment with recombinant human GH ( rhGH ) ( 4 IU given sc at 0800 h )
Jacobs et al., Clin Endocrinol (Oxf) 1996 (Diabetes Mellitus, Type 1) : We have investigated IGF-I concentrations and fasting GH concentrations and the response to 1 microgram/kg body weight GH-releasing hormone (GHRH) intravenously and/or to 150 micrograms clonidine intravenously in 77 moderately controlled patients with type I diabetes and in 46 healthy controls
Ghigo et al., J Endocrinol Invest 1997 : The individual role played by GH and IGF-I in the regulation of hypothalamic GHRH and SRIF gene expression is still object of debate
Rollero et al., Neuropsychobiology 1998 (Memory Disorders) : Basal growth hormone (GH) and insulin-like growth factor I (IGF-I) as well as GH responses to GH-releasing hormone (GHRH) were studied in 22 subjects ( 7 females, 15 males ), aged between 65 and 86 years
Drange et al., J Clin Endocrinol Metab 1998 (Acromegaly...) : GHRH levels decreased by 70 % ; glucose suppressed GH and insulin-like growth factor I levels were reduced by 90 % and 75 %, respectively, to near normal values ; urinary 5-HIAA levels normalized ; and the pituitary mass remained unchanged
Cano et al., Fertil Steril 1999 : Effect of menopause and different combined estradiol-progestin regimens on basal and growth hormone releasing hormone stimulated serum growth hormone, insulin-like growth factor-1 , insulin-like growth factor binding protein ( IGFBP)-1, and IGFBP-3 levels ... The administration of oral, but not transdermal, E2 plus medroxyprogesterone acetate at the usual clinical doses used in postmenopausal women decreased IGF-1 levels and the response of GH to GHRH in older women