Gene interactions and pathways from curated databases and text-mining

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MEF2C — NKX2-5

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

  • STRING interaction: NKX2-5 — MEF2C (interaction, mapped from grid dip)
  • STRING interaction: MEF2C — NKX2-5 (interaction, mapped from reactome)

Text-mined interactions from Literome

Nagel et al., Leukemia 2008 (Chromosome Deletion...) : Knockdown and overexpression assays confirmed MEF2C activation by NKX2-5 at both the RNA and protein levels ... Direct interactions between NKX2-5 and GATA3 as indicated by co-immunoprecipitation data may contribute to MEF2C regulation
Klaus et al., Proc Natl Acad Sci U S A 2012 (Wnt Signaling Pathway) : Using FACS enrichment of cardiac progenitors in RBPJ and RBPJ/Axin2 mutants, embryo cultures in the presence of the Bmp inhibitor Noggin, and by crossing a Bmp4 mutation into the RBPJ/Axin2 mutant background, we show that Wnt and Bmp4 signaling activate specific and nonoverlapping cardiac-specific genes in the cardiac progenitors : Nkx2-5 , Isl1 and Baf60c are controlled by Wnt/ß-catenin, and Gata4, SRF, and Mef2c are controlled by Bmp signaling
Skerjanc et al., J Biol Chem 1998 (Carcinoma, Embryonal) : During differentiation into cardiac muscle, Nkx2-5 expression resulted in the activation of myocyte enhancer factor 2C (MEF2C) , but not MEF2A, -B, or -D