Liu et al., Nature 2008
:
Disrupting SIRT1 activity, by liver-specific knockout of the Sirt1 gene or by administration of a SIRT1 antagonist, increased CRTC2 activity and glucose output, whereas exposure to SIRT1 agonists reduced them
Jeong et al., Nat Med 2012
(Disease Models, Animal...) :
The neuroprotective effect of Sirt1 requires the presence of CREB regulated transcription coactivator 1 ( TORC1 ), a brain-specific modulator of CREB activity