UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to CTNNB1

CTNNB1 — PSENEN

Pathways - manually collected, often from reviews:

NCI Pathway Database Presenilin action in Notch and Wnt signaling: beta catenin/beta TrCP1 complex (CTNNB1-FBXW11) → Gamma Secretase complex (PSEN1-NCSTN-APH1A-PSENEN-APH1B) (modification, collaborate)
Soriano et al., J Cell Biol 2001
Evidence: assay, other species

Text-mined interactions from Literome

Meredith et al., Biochem Biophys Res Commun 2002 : Gamma-secretase activity is not involved in presenilin mediated regulation of beta-catenin
Wu et al., J Cell Sci 2007 : Unexpectedly, gamma-secretase positively regulated basal cell proliferation dependent on the beta-catenin-T-cell-factor complex
Raurell et al., PloS one 2008 (Alzheimer Disease) : Gamma-secretase dependent and -independent effects of presenilin1 on beta-catenin.Tcf-4 transcriptional activity