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GPI — IFNG
Text-mined interactions from Literome
Fernandes et al., Immunology 2000
(Sporotrichosis) :
Stimulation of murine M
phi with
interferon-gamma (IFN-gamma) induced NO production and inhibition of fungal growth
Haskó et al., Immunology 2001
:
In the present study, we investigated the effect of sulphasalazine and two related compounds - sulphapyridine and 5-aminosalicylic acid - on M
phi activation
induced by bacterial lipopolysaccharide (LPS) and
interferon-gamma (IFN-gamma)
Kwan et al., Infect Immun 1992
:
These findings indicate that at least one mechanism by which Leishmania infection attenuates the
activation of M
phi by
IFN-gamma involves selective, transcriptional inhibition of major histocompatibility complex class II genes via a cAMP independent mechanism
Jaffar et al., J Immunol 2007
(Asthma...) :
In vitro studies showed that
PGI ( 2 ) did not
affect IL-4 and IL-5 production or the level of
IFN-gamma by the T cells
Stenger et al., Eur J Immunol 1991
(Leishmaniasis) :
Consistent with the conclusion that endogenously produced TNF-alpha accounts for the synergism of IL 4 with IFN-gamma is the finding that N omega-monomethyl-L-arginine, an inhibitor of the L-arginine dependent generation of microbicidal nitrogen intermediates, totally blocked the M
phi activation
induced by
IFN-gamma combined with IL 4 as well as by IFN-gamma combined with TNF-alpha
Keller et al., Eur J Immunol 1990
:
Binding of high- and low-affinity IgG as well as expression of MHC class II molecules and of tumoricidal activity by BMM
phi was markedly
enhanced by rat
interferon-gamma in low concentration ( 0.1 to 1.0 IU IFN-gamma/ml )
Stout et al., J Immunol 1989
:
IFN-gamma, in the absence of LPS, could activate the elicited M phi and to a lesser and more variable degree, the resident M
phi Only the M phi-c consistently
required both
IFN-gamma and LPS for induction of cytostatic activity ... TH2 could activate the Ag-presenting M
phi-c in the
presence of
IFN-gamma
Radzioch et al., J Immunol 1988
:
In contrast, neither H-7 nor retinal inhibited the
activation of cytotoxic M
phi by
IFN-gamma , indicating that IFN-gamma acts through a PK-C independent pathway
Wilson et al., Infect Immun 1985
:
These findings are consistent with an important role for IFN-gamma in the control of Toxoplasma infection and indicate that the anti-Toxoplasma activity of resting and
IFN-gamma activated adult and neonatal M
phi is similar
Boraschi et al., J Immunol 1984
:
However, M
phi-suppressive activity could be partially or completely
reduced by in vitro pre-exposure to nonimmune IFN-alpha or immune recombinant
IFN-gamma ... Furthermore, at variance with IFN-alpha,
IFN-gamma directly
stimulated M
phi to synthesize and release IL 1, a monokine known to promote lymphocyte proliferation
Boraschi et al., Eur J Immunol 1984
(Neoplasms, Experimental) :
In fact, at high doses
IFN-gamma could also
induce significant levels of both cytolytic and cytostatic activity in M phi of A/J and P/J mice, although it could not increase cytotoxic activities of C3H/HeJ M
phi
Blasi et al., J Immunol 1984
:
These results indicate that the
activation of pM
phi by
IFN-gamma is independent of new protein synthesis, whereas the activation of pM phi by IFN-alpha and/or IFN-beta requires active protein synthesis, suggesting that the mechanism of induction of cytotoxic pM phi by IFN-gamma differs from that by the other types of IFN
Yang et al., Mol Immunol 1995
:
cDNAs containing sequences which did not match published sequences were used to probe Northern blots prepared from both unstimulated and
IFN-gamma activated GM-CSF- and CSF-1 derived m
phi
Theus et al., Toxicol Appl Pharmacol 1993
:
Although control animals showed a typical pattern of
requiring both
interferon (IFN)-gamma and lipopolysaccharide (LPS) for m
phi activation, m phi from propanil treated animals were cytotoxic when induced with LPS alone
Heise et al., J Virol 1995
(Cytomegalovirus Infections...) :
We conclude that ( i ) M phi activation is a prominent part of inflammatory responses to herpesvirus infection and ( ii )
IFN gamma and TNF alpha
play a critical role in both virus induced M
phi activation and control of herpesvirus growth independent of T and B cells
Beaman et al., J Immunol 1994
:
These data taken together suggest that IL-6 enhances intracellular replication of T. gondii and reverses
IFN-gamma mediated activation of murine peritoneal M
phi , and that certain of the interactions between these two cytokines may be at the level of TNF-alpha triggering
Ohyama et al., No To Shinkei 1993
(Glioma) :
These findings suggest that
IFN-gamma augments the in vitro tumoricidal activation of M
phi ; This effect appears to be unrelated to any influence of IFN-gamma on target sensitivity to lysis by macrophages
Redmond et al., J Immunol 1993
(Candidiasis) :
IFN-gamma enhanced KC and PM
phi candidacidal activity
Ayala et al., J Surg Res 1993
(Hemorrhage) :
The results indicated that
IFN-gamma restored the capacity of splenic M
phi to mobilize [ Ca+2 ] i in response to FMLP
Wen et al., Cell Biol Int 1997
:
LPS, IL-1 beta and TNF alpha effectively
enhanced BK-stimulated production of
PGI2 by HPASMC, while
IFN gamma had only a weak effect on BK-stimulated PGI2 production
Heise et al., Virology 1998
(Herpesviridae Infections) :
Infection of normal M phi with MCMV at a low m.o.i. ( 0.1 to 0.2 ) impaired
IFN gamma mediated induction of M
phi MHC class II expression, but not MHC class I expression
Goñalons et al., J Immunol 1998
:
Therefore,
IFN-gamma regulates the expression of MHC class II molecules at the translational level in both B cells and M
phi and, as already reported, at the transcriptional level only in M phi