Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
Complex of MAP3K5-QARS
→
FAS
(decreases, MAP3K5/QARS Activity)
Ko et al., J Biol Chem 2001* Evidence: we investigated the molecular interaction between human glutaminyl-tRNA synthetase (QRS) and ASK1 and found the Gln-dependent association of the two molecules. While their association was enhanced by the elevation of Gln concentration, they were dissociated by Fas ligation within 5 min. The association involved the catalytic domains of the two enzymes. The ASK1 activity was inhibited by the interaction with QRS as determined by in vitro kinase and transcription assays. Finally, we have shown tha...