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ICAM1 — TIMP1
Text-mined interactions from Literome
Domeij et al., Biochem Biophys Res Commun 2005
(MAP Kinase Signaling System) :
The results suggest that co-culture with monocytes enhances cellular expression of MMP-1 and
TIMP-1 in gingival fibroblasts, and that the increased MMP-1 expression, in contrast to TIMP-1, is partly
mediated by the adhesion molecule
ICAM-1 and the p38 MAPK signal pathway
Zhang et al., J Gerontol A Biol Sci Med Sci 2006
(Albuminuria...) :
As several inflammatory mediators including intercellular adhesion molecule-1 ( ICAM-1 ) are substrates of MMPs, we speculated that
TIMP-1 might
affect ICAM-1 through MMPs and subsequently promote age related renal fibrosis ... It was found that the expressions and activities of gelatinases were downregulated ; the expressions of
ICAM-1 , collagen III, collagen IV, and transforming growth factor (TGF)-beta1 were upregulated ; and the number of infiltrating macrophages was
increased in kidneys of 24-month-old TIMP-1 transgenic mice with high expressions of
TIMP-1 , compared with wild-type mice