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EPHB2 — PTX3

Text-mined interactions from Literome

Piiper et al., Mol Pharmacol 2000 : In the present study, PTx partially inhibited CCK induced ERK1/2 activation in pancreatic AR42J cells, although activation of phospholipase C was not reduced ... PTx also inhibited ERK1/2 activation in response to the PKC activator 12-O-tetradecanoylphorbol-13-acetate ( TPA ) and epidermal growth factor (EGF) as well as activation of c-Raf-1 by EGF and CCK
Gao et al., J Pharmacol Exp Ther 2001 : ERK activation induced by the PKC activator phorbol myristate acetate was inhibited by PTX , PP1, AG1478, and calphostin C ... In contrast, activation of ERK by lysophosphatidic acid, a Gi-coupled receptor activator, was inhibited by PTX , PP1, and AG1478, but not by calphostin C
Garcia et al., Am J Physiol Cell Physiol 2001 : PTX caused a rapid time dependent increase in bovine pulmonary artery endothelial cell ERK activity that was significantly attenuated by 1 ) pharmacological inhibition of MEK, the upstream ERK activating kinase, 2 ) an MEK dominant negative construct, and 3 ) PKC inhibition with bisindolylmaleimide ... There was little evidence for the involvement of either Gbetagamma-subunits, Ras GTPases, Raf-1, p60 ( src ), or phosphatidylinositol 3'-kinases in PTX mediated ERK activation ... Both the purified beta-oligomer binding subunit of the PTX holotoxin and a PTX holotoxin mutant genetically engineered to eliminate intrinsic ADP ribosyltransferase activity completely reproduced PTX effects on ERK activation, suggesting that PTX induced ERK activation involves a novel PKC dependent signaling mechanism that is independent of either Ras or Raf-1 activities and does not require G protein ADP ribosylation
Li et al., Biochem Biophys Res Commun 2001 (MAP Kinase Signaling System) : In addition, PTX induced phosphorylation of Akt and of ERK2 , which could be completely blocked by LY294002 and PD098059, respectively, and by genistein or tyrphostin 47 as well
Bajetto et al., J Neurochem 2001 : Moreover, both astrocyte proliferation and ERK1/2 phosphorylation, induced by SDF-1alpha, were inhibited by pertussis toxin ( PTX ) and wortmannin treatment indicating the involvement of a PTX sensitive G-protein and of phosphatidyl inositol-3 kinase in the signalling of SDF-1alpha
Hung et al., Nephrol Dial Transplant 2003 (Peritoneal Diseases...) : At a concentration ( 300 micro g/ml ) that inhibited the collagen gene expression, PTX suppressed the ERK1/2 and p38 ( HOG ) activation by TGF-beta
Chiou et al., Int Immunopharmacol 2004 : We found that C5a induced, time dependent ( 1 ) ERK1/2 phosphorylation was markedly diminished by PTX , U73122, P13K inhibitors wortmannin and LY294002 and ERK1/2 inhibitor PD98059 ; ( 2 ) Akt phosphorylation was also attenuated by the above inhibitors except PD98059 ; ( 3 ) p38 MAPK phosphorylation was only affected by PTX
Moshal et al., Am J Physiol Cell Physiol 2006 (MAP Kinase Signaling System) : ERK phosphorylation was suppressed by pertussis toxin ( PTX ) , suggesting the involvement of G protein coupled receptors ( GPCRs ) in initiating signal transduction by Hcy and leading to ERK activation
Zhang et al., Am J Physiol Cell Physiol 2006 : Pertussis toxin ( PTX ) blocks LPA induced activation of p38 and ERK but only slightly inhibits LPA induced activation of Akt
Kim et al., Exp Mol Med 2007 (Calcium Signaling) : PhS1P also activated ERK and p38 kinase, and these activations by PhS1P were inhibited by PTX
Lee et al., Biochem Biophys Res Commun 2007 : LPG stimulated ERK activity was not inhibited by pertussis toxin ( PTX ) , indicating PTX-sensitive G-proteins independent manner
Jo et al., Biochem Biophys Res Commun 2008 : LPG stimulated ERK activity was inhibited by PTX , indicating the involvement of PTX-sensitive G-proteins
Vacek et al., Mol Cell Biochem 2009 : We recently reported homocysteine ( Hcy ) -induced ERK-phosphorylation was suppressed by pertussis toxin ( PTX ) , which suggested the involvement of GPCRs in initiating signal transduction
Chung et al., Arch Pharm Res 2008 : PTX inhibited S1P induced ERK1/2 activation
Miyatake et al., J Neurochem 2009 (MAP Kinase Signaling System) : This was based on the attenuation of the micro-opioid activation of ERK by pertussis toxin ( PTX ) , the CaM antagonist, W-7, and siRNA silencing of beta-arrestin2
Zhou et al., International journal of molecular sciences 2009 : In addition, pertussis toxin ( PTX ) , a Gi protein inhibitor, induced an inhibitory effect on p38 MAPK, ERK phosphorylation and RASMCs migration
Yang et al., Br J Pharmacol 2011 : Pertussis toxin ( PTX ) blocked ERK phosphorylation, suggesting receptor coupling to G ( i ) or G ( o ) proteins