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CD27 — IL2

Text-mined interactions from Literome

Matter et al., Eur J Immunol 2008 (Arenaviridae Infections) : Blocking experiments with monoclonal antibodies and the use of CD27 ( -/- ) memory CTL revealed that CD27 ligation during restimulation increased autocrine IL-2 production and secondary expansion
Peperzak et al., J Clin Invest 2010 (Orthomyxoviridae Infections) : In vitro, CD27 directed IL-2 expression and promoted clonal expansion of primed CD8+ T cells exclusively by IL-2 dependent survival signaling ... We conclude that CD27 signaling directs the IL-2 production that is reportedly essential to sustain survival of virus-specific CTLs in nonlymphoid tissue
Claus et al., Cancer Res 2012 (Neoplasms, Experimental) : CD27 signaling reduced apoptosis of Tregs in vivo and induced CD4 ( + ) effector T cells ( Teffs ) to produce interleukin-2 , a key survival factor for Tregs
Welten et al., J Virol 2013 (Acute Disease...) : Furthermore, the IL-2 production in both noninflationary and inflationary CMV-specific T cells was dependent on CD27-CD70 costimulation
Hartwig et al., J Immunol 1997 : In addition, testing a spectrum of different cytokines indicated that IL-4 and TGF, but not IL-2 , IL-10, or IFN-gamma, prevented up-regulation of CD27L expression on activated B cells even when activation was induced by Ig signaling