Vanhara et al., Differentiation 2009
(Prostatic Neoplasms) :
Moreover, GDF-15 inhibits expression of carbonic anhydrase II and cathepsin K, key osteoclast enzymes, and induces changes in SMAD and p38 signaling
Zaidi et al., J Am Coll Cardiol 2010
(Disease Models, Animal...) :
These effects might be mediated by Gdf5 induced p38-MAPK signaling in fibroblasts and Gdf5-driven Smad dependent pro-survival signaling in cardiomyocytes