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NFKBIA — SRC

Pathways - manually collected, often from reviews:

• NCI Pathway Database Atypical NF-kappaB pathway: Src (SRC) → NF kappa B1 p50/RelA/I kappa B alpha complex (NFKB1-NFKBIA-RELA) (modification, activates)
  Fan et al., J Biol Chem 2003
  Evidence: mutant phenotype, assay

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: SRC — NFKBIA (in vivo) Fan et al., J Biol Chem 2003, Imbert et al., Cell 1996*, Abu-Amer et al., J Biol Chem 1998*
• IRef Hprd Interaction: SRC — NFKBIA (in vitro) Fan et al., J Biol Chem 2003, Imbert et al., Cell 1996*, Abu-Amer et al., J Biol Chem 1998*

Text-mined interactions from Literome

Fan et al., J Biol Chem 2003 (Anoxia) : In vitro kinase assays further demonstrated that immunoprecipitated c-Src has the capacity to directly phosphorylate GST-I kappa B alpha and that this I kappa B alpha kinase activity is significantly reduced by Gpx-1 overexpression ... These results suggest that c-Src dependent tyrosine phosphorylation of I kappa B alpha and subsequent activation of NF kappa B is controlled by intracellular H ( 2 ) O ( 2 ) and defines an important redox regulated pathway for NF kappa B activation following H/R injury that is independent of the IKK complex
Crèvecoeur et al., Biochem Pharmacol 2008 : In the present study, we investigated the effect of GA on NF-kappaB activation induced by sodium pervanadate ( PV ), a tyrosine phosphatase inhibitor triggering c-Src mediated tyrosine phosphorylation of IkappaBalpha
Abu-Amer et al., J Biol Chem 1998 : Consistent with the pivotal role played by c-Src in TNF induced Ikappa Balpha tyrosine phosphorylation, NF-kappaB activation, by the cytokine, is markedly delayed and reduced in c-src-/- BMMs. Underscoring the physiological significance of c-Src activation of NF-kappaB, TNF induction of IL-6, which is an NF-kappaB mediated event, is substantially diminished in c-src-/- BMMs