Bhattacharyya et al., J Biol Chem 2008
(Inflammation) :
Additional experiments with TLR4 blocking antibody and TLR4 small interfering RNAs showed 80 % reductions in CGN induced increases in Bcl10 and IL-8
Bhattacharyya et al., J Biol Chem 2010
(Inflammation) :
TNF-a induced the ubiquitination of TRAF2 ( TNF receptor associated factor 2 ), which interacts with NIK, and CGN induced phosphorylation of BCL10 , leading to increased NIK phosphorylation