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IRF6 — LBP

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: IRF6 — LBP (direct interaction, pull down) Nagaoka et al., J Immunol 2001*

Text-mined interactions from Literome

Su et al., Hepatology 2000 : To investigate the specific role of LBP in LPS activation of Kupffer cells, we produced a functional recombinant rat LBP using a baculovirus expression system, which we used to selectively examine the role of LBP 's on Kupffer-cell function ... The effects of LBP on Kupffer cell activation by LPS are dependent on a functional Toll-like receptor 4 (Tlr 4) because Kupffer cells from C3H/HeJ mice failed to respond to LPS in the presence of LBP ... LBP plays an important role in mediating Kupffer cell activation by LPS , and these effects are dependent on the presence of functioning Tlr 4
Triantafilou et al., Eur J Biochem 2000 : Our results showed that both forms of LPS display the same binding characteristics, and that the binding of FITC-LPS to cells was both CD14- and LBP dependent for LPS concentrations up to 100 ng.mL-1
Vesy et al., Infect Immun 2000 : Soluble CD14 ( sCD14 ) did not release LPS from blebs yet could facilitate LBP mediated LPS transfer to HDL ... LBP , but not PLTP, also promoted the activation of human monocytes by bleb derived LPS ... Whereas depleting or neutralizing LBP significantly reduced LPS transfer from blebs to lipoproteins in normal human serum, neutralizing serum PLTP had no demonstrable effect
Heine et al., J Endotoxin Res 2001 : Previously, we identified an 80 kDa membrane protein ( LMP80 ) that is capable of binding to LPS and lipid A in the presence of LBP and sCD14
Reyes et al., J Pept Sci 2002 : Amino acids Trp91 and Lys92 were indispensable for peptide-LPS interaction and inhibition of LBP-LPS binding
Vreugdenhil et al., J Immunol 2003 : This LBP induced interaction of LPS with chylomicrons prevented endotoxin toxicity, as demonstrated by reduced cytokine secretion by PBMC
Thompson et al., J Biol Chem 2003 : In cell-free LPS cross linking experiments, LBP inhibited the transfer of LPS from soluble CD14 to soluble MD-2 ... Our data support the hypothesis that LBP can inhibit cell responses to LPS by inhibiting LPS transfer from mCD14 to the Toll-like receptor 4-MD-2 signaling receptor
Sancho-Tello et al., J Endocrinol 1992 : We investigated whether human granulosa-luteal ( GL ) cells exhibited lipopolysaccharide (LPS) binding protein , and the response of follicular aspirate cells to LPS in vitro
Weber et al., Immunity 2003 (Pneumococcal Infections) : Lipopolysaccharide binding protein (LBP) has a well established role in LPS induced immune responses
Guerra et al., J Endotoxin Res 2003 (Shock, Septic) : Macrophages express several lipopolysaccharide (LPS) binding proteins and are potently activated by LPS to produce inflammatory mediators
Corradin et al., J Leukoc Biol 1992 : Furthermore, both CBA and C3H/HeJ macrophages demonstrated an LBP dependent enhancement of LPS binding
Li et al., Chin J Traumatol 2003 : LPS can upregulate the intrahepatic expression of LBP mRNA and increase the plasma LBP level
Dunzendorfer et al., FASEB J 2004 (Acute-Phase Reaction) : Toll-like receptor 4 functions intracellularly in human coronary artery endothelial cells : roles of LBP and sCD14 in mediating LPS responses
Andrä et al., Biochem Pharmacol 2004 : The affinity of the peptides for LPS led to a reduced binding of lipopolysaccharide binding protein (LBP) to target membranes and hence to an inhibition of cytokine induction in human mononuclear cells
Hamann et al., Infect Immun 2005 (Acute-Phase Reaction) : Here, we report that human high-dose LBP ( hd-LBP ) suppresses binding of both R-type and S-type LPS to CD14 and inhibits LPS induced nuclear translocation of NF-kappaB, although cellular uptake of R-type LPS was found to be increased by hd-LBP ... In contrast, we found that hd-LBP enhanced the binding and uptake of S-type LPS only under serum-free conditions, whereas in the presence of serum, hd-LBP inhibited cellular binding and uptake
Mueller et al., J Immunol 2005 : Using Abs against LBP, we could show that the activation of cells by LPS was dependent on the presence of cell associated LBP , thus making LBP a possible target for the antagonistic action of phospholipids
Kitchens et al., J Endotoxin Res 2005 (Gram-Negative Bacterial Infections) : Modulatory effects of sCD14 and LBP on LPS-host cell interactions
Liu et al., Clin Exp Pharmacol Physiol 2006 (Hepatitis, Autoimmune) : TNF-alpha, IL-6, LBP and CD14 mRNA expression in mouse liver may be involved in BCG plus LPS induced liver injury
Wright et al., Science 1990 : LPS in the bloodstream rapidly binds to the serum protein, lipopolysaccharide binding protein (LBP), and cellular responses to physiological levels of LPS are dependent on LBP
Wright et al., J Exp Med 1991 : Interaction of CD14 with LPS in the presence of LBP or serum also caused a dramatic, transient increase in the adhesive activity of CR3 ( CD11b/CD18 ) on PMN
Landmann et al., J Cell Biochem 1991 : The results, showing that CD14 antigen expression is upregulated by LPS and downregulated by rIFNg and rIL-4, suggest that the LPS-LBP receptor is involved in the feedback response of IFNg and IL-4 to LPS stimulation
Tsukamoto et al., Int Immunol 2010 : Time course studies on mCD14 positive cells have demonstrated that LPS stimulation induces rapid activation of nuclear factor-kappaB and p38 in the presence of LBP ( TLR4/MD-2 receptor dimerization ) as compared with stimulation without LBP ( receptor non-dimerization )
Piazza et al., Biochem Pharmacol 2010 : This compound inhibited LBP/CD14 dependent LPS transfer to MD-2.TLR4, resulting in reduced formation of a ( LPS-MD-2-TLR4 ) ( 2 ) complex
Su et al., Am J Physiol Gastrointest Liver Physiol 2010 (Drug-Induced Liver Injury) : The peptide LBPK95A was able to inhibit LBP mediated LPS activation of RAW 267.4 cells in a dose dependent manner in vitro
Youn et al., Eur J Immunol 2011 (Disease Models, Animal...) : Both HPep1 and HPep6 peptides inhibited binding of LPS to LBP and HMGB1, LBP mediated LPS transfer to CD14, and cellular uptake of LPS in RAW264.7 cells
Zeng et al., Ann Surg 2012 (Bacterial Infections...) : The 9 htSNPs were genotyped using pyrosequencing method and analyzed in relation to the risk of development of sepsis and MOD, LBP production, and lipopolysaccharide (LPS) induced activation of peripheral blood leukocytes
Cotroneo et al., Innate Immun 2012 (Disease Models, Animal...) : Lipopolysaccharide binding protein (LBP) augments LPS signaling through TLR4
Ding et al., Innate Immun 2013 (Bacteroidaceae Infections) : The results showed that the expression of LBP mRNA and peptide was significantly up-regulated by P. gingivalis LPS ( 1690 ) and E. coli LPS, while P. gingivalis LPS ( 1435/1449 ) did not affect LBP expression
Sulyok et al., Br J Anaesth 2012 (Colorectal Neoplasms...) : The following parameters were measured : lipopolysaccharide (LPS) induced tumour necrosis factor (TNF)-a, procalcitonin ( PCT ), interleukin (IL)-6/10, heat shock proteins ( HSPs ) 60, 70, and 90, human leucocyte antigen-DR ( HLA-DR ), and LPS binding protein (LBP)
Ding et al., Molecular oral microbiology 2013 : Furthermore, different isoforms of P. gingivalis LPS differently modulate the immuno-inflammatory response, and P. gingivalis LPS1690 induces LBP expression in human oral keratinocytes ( HOKs ) ... This study further examined the signaling mechanisms of P. gingivalis LPS1690 -induced and Escherichia coli LPS induced LBP expression in HOKs ... Both P. gingivalis LPS1690 and E. coli LPS were potent inducers of LBP expression in HOKs ... Further blocking assay showed that P. gingivalis LPS1690 induction of LBP was through NF-?B and p38 MPAK pathways, whereas E. coli LPS induced LBP expression was mediated by NF-?B, p38 MPAK and JNK pathways
Wright et al., J Exp Med 1989 : Moreover, MO did not recognize erythrocytes coated with LBP unless LPS was also added, thus suggesting that interaction of LBP with LPS results in a conformational change in LBP that allows recognition by MO. Binding of LBP coated particles appears to be mediated by a receptor found on blood monocytes and MO but not on other leukocytes or umbilical vein endothelium
Schindler et al., Clin Nephrol 1993 (Kidney Failure, Chronic) : Both bactericidal/permeability increasing factor ( BPI ), a protein stored in neutrophils, and the acute phase protein LPS binding protein (LBP) bind to LPS ; however, BPI inhibits while LBP enhances binding of LPS to leukocytes and subsequent induction of cytokines
Han et al., J Biol Chem 1994 : Additionally, NH-LBP inhibited LPS binding to LBP, inhibited the LBP promoted binding of LPS to CD14, and inhibited the LBP dependent activation of rabbit peritoneal exudate macrophages
Grube et al., J Biol Chem 1994 (Carcinoma, Hepatocellular...) : LBP biosynthesis was evaluated by immunoprecipitation of 35S labeled LBP from HepG2 supernatants, measurement of steady-state LBP mRNA levels, and analysis of LBP dependent LPS binding to CD14 positive cells
Theofan et al., J Immunol 1994 : Both forms of LBP bound to LPS with the same affinity, and similarly inhibited LPS activity in the Limulus amebocyte lysate assay
Gallay et al., Proc Natl Acad Sci U S A 1994 (Shock, Septic) : In vitro, we demonstrated that they interfere with LPS binding to monocytes or polymorphonuclear cells in different ways : by the mere prevention of binding of LPS to LBP thus preventing the binding of LPS to CD14, or by reacting with LPS-LBP complexes thus mediating their binding to complement or Fc receptors on monocytes and on polymorphonuclear cells
Yu et al., J Inflamm 1995 : Binding of both LBP and Mac-2-BP to CD14 required the simultaneous presence of LPS
Tobias et al., J Immunol 1993 : mAb to the MO plasma membrane protein, CD14, inhibit LBP dependent binding of LPS to MO, and LPS-LBP dependent stimulation of cytokine release from MO ... Studies with human CD14 expressing transfectants of the murine B cell line 70Z/3 also revealed LBP dependent cross linking of 125I-ASD-LPS to CD14
Pugin et al., Proc Natl Acad Sci U S A 1993 : Myeloid cell activation by lipopolysaccharides (LPS) involves two proteins, plasma LPS binding protein (LBP) and cell-membrane CD14
Haziot et al., J Immunol 1993 : In the presence of LBP , LPS strongly activates monocytes via CD14 as measured by TNF secretion
Kirkland et al., J Biol Chem 1993 : LBP was required for LPS binding to CD14
Wan et al., Infect Immun 1995 : The induction of LBP by IL-6 or LPS was attenuated by dexamethasone ... In contrast to IL-6 and LPS, in the presence of 10 ( -6 ) M dexamethasone, IL-1 and tumor necrosis factor (TNF) led to maximal LBP mRNA induction levels, 4.7- and 3.8-fold, respectively, suggesting that IL-6 and LPS stimulate LBP expression by mechanisms different from those of IL-1 and TNF
Dentener et al., J Immunol 1993 : Also, it was observed that both BPI and LBP inhibited LPS activity in the chromogenic LAL assay
Heumann et al., J Infect Dis 1993 : To be efficient in vivo, BPI should overcome the action of LPS binding protein (LBP), a serum molecule that increases the expression of LPS-inducible genes via CD14 of monocytes, rBPI23, a recombinant fragment of BPI, prevented in a dose dependent manner the binding and the internalization of LPS mediated by LBP
Pugin et al., Prog Clin Biol Res 1995 (Gram-Negative Bacterial Infections...) : The role of LBP is to transfer LPS to sCD14 and newly formed LPS-sCD14 will in turn activate endothelial cells via an as yet unknown surface receptor
Horadagoda et al., Vet Immunol Immunopathol 1995 (Acute-Phase Reaction) : Bovine LBP enhanced the binding of LPS to human monocytes while enzymatic removal of the CD14 receptor abrogated this interaction
Su et al., Crit Rev Immunol 1995 : In the presence of LBP , 100-fold less LPS is required to trigger this cytokine response
Troelstra et al., Infect Immun 1997 : In conclusion, we found an HPS- or LBP dependent binding of FITC-LPS to monocytes that was CD14 dependent at up to 100 ng of LPS per ml, and saturation of binding was shown
Malhotra et al., Bioessays 1997 (Bacteremia...) : It is well established that, in the presence of plasma LPS binding protein (LBP) , LPS binds with high affinity to CD14
Wurfel et al., J Exp Med 1997 : The role of LBP in promoting LPS responsiveness in vivo was tested in LBP-deficient mice produced by gene targeting in embryonic stem cells
Dziarski et al., J Biol Chem 1998 : LPS binding protein (LBP) increased the binding of sCD14 to sPGN by adding another lower affinity KD and another higher Bmax, but for ReLPS, LBP increased the affinity of binding by yielding two KD with significantly higher affinity ( 7.1 and 27 nM )
Tapping et al., Prog Clin Biol Res 1998 : Roles for LBP and CD14 in the LPS dependent activation of a wide variety of cells have been established