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GRK6 — OPRM1

Text-mined interactions from Literome

Wang et al., Neuropharmacology 2000 : These results suggest that homologous desensitization of rat mu-opioid receptors results from the activation of GRK2 and that a cluster of Ser/Thr residues ( Thr354Ser355Ser356Thr357 ) at the intracellular carboxyl tail plays an important role in GRK2 mediated mu-opioid receptor desensitization
Carman et al., J Biol Chem 2000 : Similarly, wild-type GRK2 but not GRK2 ( K567E/R578E ) or GRK2 ( R587Q ) promoted morphinedependent phosphorylation of the mu-opioid receptor in cells
Johnson et al., Mol Pharmacol 2006 : Expression of a dominant negative mutant G protein coupled receptor kinase 2 ( GRK2 ), GRK2-K220R, markedly attenuated the DAMGO induced desensitization of MOR1, but it had no effect on morphine induced MOR1 desensitization
Moulédous et al., J Biol Chem 2012 (Neuroblastoma...) : Using siRNA knockdown we could demonstrate that 1DMe induced Ser-377 cross-phosphorylation and MOP receptor loss of function were mediated by the G protein receptor kinase GRK2 ... These data show that NPFF induced heterologous desensitization of MOP receptor signaling is mediated by GRK2 and could involve transphosphorylation within the heteromeric receptor complex