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GNRH1 — TNF

Text-mined interactions from Literome

Russell et al., J Neuroendocrinol 2001 : We examined the effects of TNF-alpha and IL-6 on LHRH release from hypothalamic explants harvested from proestrus female and male rats in vitro
Matsuwaki et al., Endocrinology 2003 (Infection) : We have previously shown that TNF-alpha , a major proinflammatory cytokine, suppressed hypothalamic GnRH pulse generator activity and that this inhibitory effect was enhanced by alpha-helical CRH, a CRH receptor antagonist
Fernandez-Solari et al., Ann N Y Acad Sci 2006 : Participation of the endocannabinoid system in the effect of TNF-alpha on hypothalamic release of gonadotropin releasing hormone ... Second, we showed that TNF-alpha reduced significantly the forskolin stimulated LHRH release and that the CB1-r antagonist AM251 ( 10 ( -5 ) M ) blocked that inhibition, supporting the hypothesis that TNF-alpha inhibits LHRH release, acting at least in part by activating the endocannabinoid system
Yoo et al., Endocr J 1997 : Tumor necrosis factor-alpha mediates endotoxin induced suppression of gonadotropin releasing hormone pulse generator activity in the rat