◀ Back to RELA
BMP2 — RELA
Text-mined interactions from Literome
Feng et al., J Biol Chem 2003
:
NF-kappaB specifically
activates BMP-2 gene expression in growth plate chondrocytes in vivo and in a chondrocyte cell line in vitro ... Here we have used both in vitro and in vivo approaches to demonstrate that transcription factor,
NF-kappaB ,
regulates BMP-2 gene expression in chondrocytes ... Thus,
NF-kappaB may positively
regulate BMP-2 gene transcription ... Therefore, in postnatal growth plate chondrocytes, expression of
BMP-2 is
regulated by
NF-kappaB , which may play an important role in chondrogenesis
Eliseev et al., Exp Cell Res 2006
(Bone Neoplasms...) :
Here, we show that in osteosarcoma Saos2 osteoblasts,
NFkappaB regulates the activity of the
BMP/Smad signaling ... We therefore conclude that in osteosarcoma Saos2 cells,
NFkappaB represses
BMP/Smad signaling and BMP2 induced differentiation through Smad7
Sugimori et al., J Bone Miner Metab 2005
:
We investigated the involvement of phosphatidylinositol 3-kinase (PI3K)/Akt mediated
NF-kappaB activation by
BMP-2 stimulation in the modulation of this antiapoptotic process in a chondrocytic cell line, N1511 ... Thus,
BMP-2 induced
NF-kappaB activation is mediated by PI3K/Akt signaling
Ghosh-Choudhury et al., J Biol Chem 2006
:
BMP-2 stimulates receptor activator of
NF-kappaB ligand expression
Tintut et al., J Investig Med 2006
(Atherosclerosis...) :
Binding of RANKL to its cognate receptor RANK induces
NF-kappaB signaling, which stimulates osteoclastic differentiation in preosteoclasts and
induces bone morphogenetic protein ( BMP-2 ) expression in chondrocytes
Zhang et al., Vasc Med 2008
:
Our findings indicate that Ang II-induced
BMP-2 expression might
contribute to
NF-kappaB activation
Graham et al., Prostate 2009
(Neoplasm Metastasis...) :
PI3K/Akt dependent transcriptional regulation and
activation of
BMP-2-Smad signaling by
NF-kappaB in metastatic prostate cancer cells ... In this study, we investigated whether the nuclear transcription factor
NF-kappaB , implicated in PC metastasis, is
involved in transcriptional regulation and activation of
BMP-2 or BMP-4/Smad signaling in PC cells ... Selective inhibition of PI3K/Akt suppressed the
NF-kappaB induced
BMP-2 promoter activity ... Notably, the activation of BMPRII by
BMP-2 is
required for modulation of Smad activation by
NF-kappaB in PC cells ... Based on ChIP analysis, the transcriptional
regulation of
BMP-2 gene by
NF-kappaB may be partially attributed to binding to kappab site on the BMP-2 promoter
Hess et al., Bone 2009
:
The
IKK2/NF-kappaB induced
BMP-2 up-regulation results in the enhancement of RUNX2 and Osterix expression, two critical regulators of the osteogenic differentiation program
Graham et al., Cancer Sci 2010
(Neoplasm Metastasis...) :
We recently reported that phosphoinositide 3-kinase (PI3K)/protein kinase B ( Akt ) mediates transcriptional regulation and
activation of
bone morphogenetic protein (BMP)-2 signaling by
nuclear factor (NF)-kappaB in bone metastatic prostate cancer cells
Mohan et al., Invest Ophthalmol Vis Sci 1998
:
BMP2 and BMP4
stimulated activation of
NF-kappaB ... Actinomycin D and SN50 peptide, but not SN50M control peptide, inhibited
NF-kappaB activation in
response to
BMP2 or BMP4