Gene interactions and pathways from curated databases and text-mining

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CARD16 — RELA

Text-mined interactions from Literome

Koseki et al., J Biol Chem 1999 : Point mutations in highly conserved residues in the CARD of CIPER disrupted the ability of CIPER to activate NF-kappaB and to form homodimers, indicating that the CARD is essential for NF-kappaB activation and dimerization
Bertin et al., J Biol Chem 2000 : When expressed in cells, CARD9 binds to BCL10 and activates NF-kappaB
Bertin et al., J Biol Chem 2001 : When expressed in cells, CARD11 and CARD14 activate NF-kappaB and induce the phosphorylation of BCL10
Druilhe et al., Cell Death Differ 2001 : Moreover, Pseudo-ICE , but not ICEBERG, interacts with the CARD containing kinase RICK/RIP2/CARDIAK and activates NF-kappaB ... Our data suggest that Pseudo-ICE and ICEBERG are intracellular regulators of caspase-1 activation and could play a role in the regulation of IL-1beta secretion and NF-kappaB activation during the pro-inflammatory cytokine response
Fontalba et al., J Immunol 2007 (Arthritis, Rheumatoid) : Thus, CARD8 may control NF-kappaB activation through a regulatory loop