Gene interactions and pathways from curated databases and text-mining

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NPY4R — RELA

Text-mined interactions from Literome

Liu et al., J Leukoc Biol 2001 (Gout) : PP1 inhibited crystal induced phosphorylation of ERK1/2 and IkappaBalpha and suppressed IkappaB kinase (IKK) activation and NF-kappaB binding to the IL-8 promoter, signals that mediate MSU induced IL-8 expression
Burr et al., Exp Brain Res 2002 : However, activated NF-kappaB levels were reduced by a guanylate cyclase inhibitor, the Src-family tyrosine kinase inhibitor PP1 , or the farnesyl transferase inhibitors manumycin and farnesyl transferase ( Ftase ) inhibitor 1
Lee et al., J Immunol 2007 (Respiratory Distress Syndrome, Adult) : PP1 also blocked LPS induced NF-kappaB activation, and phosphorylation and degradation of IkappaB-alpha