◀ Back to RELA
RELA — RELB
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
Complex of NFKB1-RELA-RELB-REL-NFKB2
Nonaka et al., Oncogene 2005
-
IRef Bind Interaction:
Complex of 13 proteins
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Bind Interaction:
Complex of 16 proteins
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Bind Interaction:
Complex of 11 proteins
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Bind Interaction:
Complex of 17 proteins
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Bind Interaction:
Complex of 16 proteins
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Bind Interaction:
Complex of RELB-REL-TNIP2-NFKB1-RELA-NFKBIA-NFKB2-IKBKG-NFKB1
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Bind Interaction:
Complex of NFKB2-RELB-NFKB1-RELA
Nonaka et al., Oncogene 2005
-
IRef Biogrid Interaction:
RELB
—
RELA
(physical association, affinity chromatography technology)
Lee et al., Mol Cell 2011*
-
IRef Biogrid Interaction:
RELB
—
RELA
(physical association, affinity chromatography technology)
Bouwmeester et al., Nat Cell Biol 2004
-
MIPS CORUM NFKB1-NFKB2-REL-RELA-RELB complex:
NFKB1-NFKB2-REL-RELA-RELB complex complex (NFKB1-NFKB2-REL-RELA-RELB)
Nonaka et al., Oncogene 2005
-
MIPS CORUM NFKB1-NFKB2-RELA-RELB complex:
NFKB1-NFKB2-RELA-RELB complex complex (NFKB1-NFKB2-RELA-RELB)
Nonaka et al., Oncogene 2005
-
MIPS CORUM TNF-alpha/NF-kappa B signaling complex (CHUK, KPNA3, NFKB2, NFKBIB, REL, IKBKG, NFKB1, NFKBIE, RELB, NFKBIA, RELA, TNIP2):
TNF-alpha/NF-kappa B signaling complex (CHUK, KPNA3, NFKB2, NFKBIB, REL, IKBKG, NFKB1, NFKBIE, RELB, NFKBIA, RELA, TNIP2) complex (CHUK-IKBKG-KPNA3-NFKB1-NFKB2-NFKBIA-NFKBIB-NFKBIE-REL-RELA-RELB-TNIP2)
Bouwmeester et al., Nat Cell Biol 2004
-
MIPS CORUM TNF-alpha/Nf-kappa B signaling complex (RPL6, RPL30, RPS13, CHUK, DDX3X, NFKB2, NFKBIB, REL, IKBKG, NFKB1, MAP3K8, RELB, GLG1, NFKBIA, RELA, TNIP2, GTF2I):
TNF-alpha/Nf-kappa B signaling complex (RPL6, RPL30, RPS13, CHUK, DDX3X, NFKB2, NFKBIB, REL, IKBKG, NFKB1, MAP3K8, RELB, GLG1, NFKBIA, RELA, TNIP2, GTF2I) complex (CHUK-DDX3X-GLG1-GTF2I-IKBKG-MAP3K8-NFKB1-NFKB2-NFKBIA-NFKBIB-REL-RELA-RELB-RPL30-RPL6-RPS13-TNIP2)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Corum Interaction:
Complex of NFKB1-RELB-NFKB2-REL-RELA
(association, electrophoretic mobility shift assay)
Nonaka et al., Oncogene 2005
-
IRef Corum Interaction:
Complex of NFKB2-NFKB1-RELA-RELB
(association, electrophoretic mobility shift assay)
Nonaka et al., Oncogene 2005
-
IRef Corum Interaction:
Complex of 18 proteins
(association, tandem affinity purification)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Corum Interaction:
Complex of 13 proteins
(association, tandem affinity purification)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Dip Interaction:
RELB
—
RELA
(physical association, tandem affinity purification)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Hprd Interaction:
Complex of 290 proteins
(in vivo)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Hprd Interaction:
Complex of 145 proteins
(in vivo)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Hprd Interaction:
RELA
—
RELB
(in vitro)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Intact Interaction:
Complex of COMMD1-RELA-NFKB2-NFKB1-REL-RELB
(association, pull down)
Burstein et al., J Biol Chem 2005
-
IRef Intact Interaction:
Complex of RELB-NFKB1-NFKB2-REL-SIN3A-RELA-BCL3
(association, anti bait coimmunoprecipitation)
Barré et al., EMBO J 2007
-
IRef Intact Interaction:
Complex of NFKB1-RELB-RELB-NFKB1-RELA-RELA
(association, anti bait coimmunoprecipitation)
Hammond et al., PloS one 2012*
-
IRef Intact Interaction:
Complex of COMMD8-NFKB1-RELA-RELB
(association, pull down)
Burstein et al., J Biol Chem 2005
-
IRef Intact Interaction:
Complex of RELB-COMMD4-NFKB1-RELA
(association, pull down)
Burstein et al., J Biol Chem 2005
-
IRef Intact Interaction:
Complex of RELA-COMMD5-NFKB1-RELB
(association, pull down)
Burstein et al., J Biol Chem 2005
-
IRef Intact Interaction:
RELB
—
RELA
(physical association, tandem affinity purification)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Intact Interaction:
Complex of BCL3-NFKB1-NFKB2-REL-SIN3A-RELA-NFKB2-RELB
(association, anti bait coimmunoprecipitation)
Barré et al., EMBO J 2007
-
IRef Intact Interaction:
Complex of NFKB1-RELB-NFKB2-COMMD10-RELA
(association, pull down)
Burstein et al., J Biol Chem 2005
-
IRef Intact Interaction:
Complex of NFKB2-RELB-COMMD2-NFKB1-RELA
(association, pull down)
Burstein et al., J Biol Chem 2005
-
IRef Ophid Interaction:
RELB
—
RELA
(aggregation, confirmational text mining)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Ophid Interaction:
RELB
—
RELA
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Xia et al., Mol Cell Biol 1999
(Inflammation) :
RelB , a member of this family, has been characterized as a transcription activator and is
involved in the constitutive
NF-kappaB activity in lymphoid tissues
Bren et al., Oncogene 2001
:
Transcription of the
RelB gene is
regulated by
NF-kappaB ...
RelA is alone sufficient to
induce RelB gene transcription and to mediate the stimuli-driven increase in RelB transcription
Haddad et al., J Pharmacol Exp Ther 2002
(Inflammation...) :
Whereas selective inhibition of PDEs 1, 3, and 4, by the action of 8-methoxymethyl-3-isobutyl-1-methylxanthine, amrinone, and rolipram, respectively, exhibited a tendency to augment the translocation of NF-kappaB ( 1 ) ( p50 ), RelA ( p65 ),
RelB ( p68 ), and c-Rel ( p75 ), selective blockade of PDE 5, 6, and 9, by the action of 4- [ [ 3',4'- ( methylenedioxy ) benzyl ] amino ] -6-methoxyquinazoline and zaprinast,
attenuated lipopolysaccharide-endotoxin (LPS) mediated
NF-kappaB translocation
Valéro et al., J Immunol 2002
(Autoimmune Diseases...) :
Upon TNF induced activation of NZB thymocytes, nuclear translocation and DNA binding of RelA- and
RelB dependent
NF-kappaB heterodimers are significantly reduced
Marienfeld et al., J Biol Chem 2003
:
Furthermore, electrophoretic mobility shift analysis revealed that in vitro translated
RelB impaired the DNA binding activity of RelA and that overexpressed RelB significantly
reduced tumor necrosis factor-alpha induced
RelA activity in murine embryonic fibroblasts
Derudder et al., J Biol Chem 2003
:
LTbetaR induced binding of
RelB/p50 requires processing of p100 that is mediated by IKKalpha but is
independent of IKKbeta, NEMO/IKKgamma, and
RelA
Sivakumar et al., J Exp Med 2003
:
Moreover,
NF-kappa B-inducing kinase (NIK) was
required for both constitutive thymic DNA binding of
RelB and the specific induction of RelB complexes in vitro
Monaco et al., Proc Natl Acad Sci U S A 2004
(Arteriosclerosis...) :
We found that
NF-kappa B is activated in these cells and that this activity
involves p65, p50, and c-Rel but not p52 or
RelB
Yan et al., Immunol Cell Biol 2005
:
VLP induced induction of costimulatory molecule expression,
RelB activation and cytokine secretion by DC was
blocked by inhibition of
NF-kappaB activation, heparin or TLR4 mAb
Ruben et al., Genes Dev 1992
:
Transfection experiments demonstrate that
I-Rel suppresses
NF-kappa B-induced transcription, probably through its association with p50
Iwamoto et al., Tohoku J Exp Med 2005
(Body Weight...) :
Supershift assays with specific antibodies revealed that p50, but not p52, p65,
Rel B , or c-Rel, may be
involved in the activation of
NF-kappaB , though the component primarily responsible for the increase could not be determined
Jacque et al., Proc Natl Acad Sci U S A 2005
:
Remarkably, we show that RelA serine-276, the phosphorylation of which is induced by TNF receptor ligation, is crucial for
RelA/RelB complex formation and subsequent
inhibition of
RelB DNA binding
Starkey et al., Diabetes 2006
(Diabetes Mellitus, Experimental) :
Cytosolic content of NF-kappaB canonical pathway proteins did not differ between experimental groups after 3 months of diabetes, while NF-kappaB noncanonical pathway proteins were affected, including increased phosphorylation of inhibitor of kappaB kinase-alpha and several fold increases in
NF-kappaB inducing kinase and
RelB , which were predominantly located in tubular epithelial cells
Eisner et al., FEBS Lett 2006
:
Supershift analysis revealed that p65 and
RelB ( but not p50, p52 or cRel ) were
involved in the binding of
NFkappaB to DNA
Martucci et al., J Leukoc Biol 2007
:
The transcription factor
NF-kappaB is a central regulator of immunity, and of the NF-kappaB family,
RelB is particularly
involved in the expression of genes important in immune responses
Schumann et al., Proc Natl Acad Sci U S A 2007
:
Up-regulation of FLIP enhanced NF-kappaB activity via
NF-kappaB inducing kinase and
RelB
Wang et al., Nat Cell Biol 2007
(Breast Neoplasms...) :
ERalpha signalling reduced levels of functional
NF-kappaB and Fra-2 AP-1 and
inhibited de novo
RelB synthesis, leading to an inverse correlation between RELB and ERalpha gene expression in human breast cancer tissues and cell lines
Sanz et al., PloS one 2010
:
TWEAK, but not TNFalpha used as control ), induced a delayed increase in CCL21a mRNA ( 3.5+/-1.22-fold over control ) and CCL21 protein ( 2.5+/-0.8-fold over control ), which was prevented by inhibition of the proteasome, or siRNA targeting of NIK or
RelB , but not by
RelA inhibition with parthenolide
Liu et al., Bing Du Xue Bao 2013
:
Further investigations indicated that
RelB not only
promoted the Vpr mediated activation of
NF-kappaB reporter gene, but also enhanced the transactivation of HIV LTR
Altaf et al., Inflammopharmacology 2013
:
Inhibition by sc-514 of
RelA , c-rel and p50 expression occurred with all four particles, p52 was decreased for all diamond particles ( but not CoCr ) and
RelB was not
inhibited with any of the particles
Weih et al., Oncogene 1994
:
Although
RelB protein is present at significantly lower levels in thymus and spleen extracts when compared to RelA, in both tissues the predominant kappa B-binding activity consists of p50/RelB and p52/RelB heterodimers and only very little binding of
RelA containing complexes to kappa B sites was
detected
Weih et al., J Exp Med 1997
(Abnormalities, Multiple...) :
These results indicate that the lack of
RelB is, in part, compensated by other p50 containing complexes and that the `` classical ''
p50-RelA-NF-kappaB activity is not
required for the development of the inflammatory phenotype