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EPHB2 — MAP2K5

Text-mined interactions from Literome

Cavanaugh et al., J Neurosci 2001 : BDNF stimulation of ERK5 required the activity of MEK5
Nicol et al., EMBO J 2001 (Cardiomyopathy, Dilated) : The MAPK kinase MEK5 activates the MAPK ERK5
Meerzaman et al., Am J Physiol Lung Cell Mol Physiol 2001 : The activation of ERK2 was completely blocked either by a dominant negative Ras mutant or in the presence of a mitogen activated protein kinase kinase ( MEK ) inhibitor
Bobrovskaya et al., J Neurochem 2001 (MAP Kinase Signaling System) : The inhibitors of mitogen activated protein kinase kinase 1/2 ( MEK1/2 ) activation, PD98059 ( 0.1-50 microM ) and UO126 ( 0.1-10 microM ), dose-dependently inhibited both ERK2 and Ser31 phosphorylation on TOH in response to AII, suggesting MEK1/2 involvement
Wang et al., J Hepatol 2002 (MAP Kinase Signaling System) : PD 98059, a mitogen activated protein kinase kinase inhibitor, and glutathione, an anti-thiol-oxidant, not only blocked Cpd 5-induced ERK phosphorylation, but also antagonized the activation of CPP-32, the altered Bcl-2/Bax expression, and DNA fragmentation
Utsugi et al., Eur J Pharmacol 2002 : Furthermore, mitogen activated protein kinase kinase ( MEK)-1-specific inhibitor, 2- ( 2-amino-3-methoxyphenyl ) -4H-1-benzopyran-4-one ( PD 98059 ), blocked the lipopolysaccharide induced p44/42 ERK activation and PDGF production
Terasawa et al., Genes Cells 2003 : MEK5 is a specific activator of ERK5
Huang et al., Biochem Biophys Res Commun 2003 : Select point mutations in subdomain X impair MEKK2 phosphorylation of the MAP2Ks, MKK7 and MEK5 , abolish MEKK2 induced activation of the MAPKs, JNK1 and ERK5 , and diminish MEKK2 dependent activation of an AP-1 reporter gene
Suthiphongchai et al., Oncol Res 2003 (Adenocarcinoma...) : Inhibition of mitogen activated protein kinase kinase 1 ( MEK1 ), an upstream regulator of ERK1/2 , with PD98059 resulted in a dose dependent reduction of invasiveness with different IC50 values in the three Dunning cell lines
Nakamura et al., J Biol Chem 2003 : Activated MEK5 then phosphorylates and activates ERK5
Cameron et al., J Biol Chem 2004 : Differential role of MEK5alpha and MEK5beta in BMK1/ERK5 activation
Xu et al., J Biol Chem 2004 : ERK5 activation was blocked by the MEK5 inhibitor U0126 and expression of a dominant negative MEK5 mutant
Ohnishi et al., J Biol Chem 2004 : However, PD98059, a specific inhibitor of mitogen activated protein kinase kinase ( MEK1 ), inhibited ERK activation by TGF-beta(1), and consequently attenuated TGF-beta(1) enhancement of its own mRNA expression in PSCs
Song et al., J Leukoc Biol 2004 : Constitutively active mitogen activated protein kinase kinase ( MEK ) induced MIP-1alpha, and Ras dominant negative ( DN ) inhibited IC-induced ERK phosphorylation and MIP-1alpha production
Hii et al., J Biol Chem 2004 : Dose response studies demonstrated a bell shaped profile of fMLP stimulated MEK5 and ERK5 activation , but this was left shifted when compared with the profile of fMLP stimulated chemotaxis
Raines et al., Biochem J 2006 : Ca2+ mediated ERK1/2 activation in NO* producing cells could be restored by exogenous expression of constitutively active mitogen activated protein kinase kinase 1
Dudderidge et al., Br J Cancer 2007 (Prostatic Neoplasms) : In both in vitro systems induction of MEK5 expression resulted in increased levels of phosphorylated ERK5 and Mcm2, geminin and Ki67 proteins
Nakamura et al., Mol Cell Biol 2007 : This C-terminal extension encodes an ERK5 docking site required for MEK5 activation of ERK5
Chen et al., J Neurochem 2008 : Although mitogen activated protein kinase kinase ( MEK ) and extracellular signal regulated protein kinase ( ERK ) are activated by GW5074, pharmacological inhibition of MEK-ERK signaling by U0126 or PD98059 does not reduce neuroprotection suggesting that B-Raf signals through a non-canonical signaling pathway
Li et al., Biochem Biophys Res Commun 2008 : These findings indicate that flow inhibits TNF mediated signaling events in EC by a mechanism dependent on activation of MEK5-BMK1 , but not MEK1-ERK1/2
Shishido et al., Circ Res 2008 (Diabetes Mellitus, Experimental...) : Constitutively active form of MEK5alpha ( CA-MEK5alpha ) inhibited ERK5-SUMOylation independent of kinase activity, but dependent on MEK5-ERK5 association
Ko et al., Carcinogenesis 2008 (Carcinoma, Non-Small-Cell Lung...) : Enhancement of ERK1/2 signaling by constitutively active mitogen activated protein kinase kinase 1/2 ( MKK1/2-CA ) increased Rad51 protein levels and protein stability in gefitinib and cisplatin or MMC cotreated cells
Tatake et al., Biochem Biophys Res Commun 2008 : The MEK5 inhibitors blocked phosphorylation of ERK5 , without affecting phosphorylation of ERK1/2 in sorbitol stimulated HeLa cells
Lorenz et al., Nat Med 2009 (Cardiomegaly...) : ERK1/2 is activated by mitogen activated protein kinase kinase-1 ( MEK1 ) and MEK2 ( commonly referred to as MEK1/2 ) -dependent phosphorylation in the TEY motif of the activation loop, but how ERK1/2 is targeted toward specific substrates is not well understood
Huang et al., Carcinogenesis 2009 (Glioma) : U-0126, the mitogen activated protein kinase kinase ( MAPK kinase ) inhibitors blocked ERK activation and cell proliferation induced by diazoxide
Petecchia et al., Chest 2009 (MAP Kinase Signaling System) : The involvement of epidermal growth factor receptor (EGFR)-extracellular signal regulated kinase ( ERK ) 1/2 cascade in CSC induced damage was shown by the observation that exposure to CSC ( 5 % ) induced a marked phosphorylation of ERK1/2, already detectable after 5-min incubation and confirmed by the demonstration that not only ERK1/2 phosphorylation but also CSC induced TJ disassembly and DNA fragmentation were partially inhibited by a mitogen activated protein kinase kinase inhibitor ( U0126 ) and completely blocked by a EGFR inhibitor ( AG1478 )
Wu et al., Can J Physiol Pharmacol 2010 (Diabetes Mellitus, Experimental) : Activation of ERK5 by constitutively active MEK5 ( caMEK5 ) upregulated KLF2 and suppressed ET-1 expression in both cell lines, whereas ERK5 siRNA transfection resulted in decreased ERK5 and KLF2 and increased ET-1 mRNA expression
Clark et al., Microcirculation 2011 : MEK5 induction of KLF4 is mediated by ERK5
Luo et al., Oncogene 2011 : Ectopic expression of constitutively active mitogen activated protein kinase kinase 1 ( MKK1 ) resulted in activation of ERK1/2 and partially prevented CPX inhibition of LEC tube formation
Drew et al., Biochim Biophys Acta 2012 (MAP Kinase Signaling System...) : MEK5 is the upstream activator of ERK5 in many epithelial cells
Pan et al., J Biol Chem 2012 : By contrast, ectopic activation of endogenous ERK5 signaling via expression of constitutive active MEK5 , an upstream activating kinase for ERK5, promotes neurogenesis in cultured aNPCs and in the dentate gyrus of the mouse brain
Yang et al., Genetics and molecular research : GMR 2012 (MAP Kinase Signaling System) : Constitutive activation of the mitogen activated protein kinase kinase 1 ( CaMEK ) can promote ERK1/2 expression, which is thereby expected to exert protective action on the heart against ischemia-reperfusion injury
Li et al., PloS one 2013 : By contrast, ectopic activation of endogenous ERK5 signaling via expression of constitutive active MEK5 , an upstream activating kinase for ERK5, stimulates neurogenesis
Ludwig et al., J Biol Chem 1998 : ERK activation is strongly enhanced by overexpression of p38 and mitogen activated protein kinase kinase 6 ( MKK6 ) but is blocked by dominant negative kinase versions of p38 and MKK6 or the specific p38 inhibitor SB203580