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EPHB2 — PML
Text-mined interactions from Literome
Son et al., Cancer Lett 2007
(Breast Neoplasms) :
We concluded that PML and all-trans-retinoic acid cause cell death by different pathways :
PML activates
ERK1/2 , p38 MAPK, and p21 ; arrests the cell cycle ; and later causes cell death ; and all-trans-retinoic acid activates proteasome function, caspase cleavage, and apoptosis
Barbarroja et al., Br J Haematol 2008
(Cell Transformation, Neoplastic...) :
To our knowledge, this is the first report to show that
PML/RARalpha was
suppressed by
MEK/ERK inhibition, through a mechanism dependent on caspase activation
Lim et al., J Biol Chem 2011
:
Taken together, our results support a model in which Pin1 promotes
PML degradation in an
ERK2 dependent manner